Skip to main content

Advertisement

Log in

Allogene Meniskustransplantation

Meniscal allograft transplantation

  • Leitthema
  • Published:
Der Orthopäde Aims and scope Submit manuscript

Zusammenfassung

Aufgrund der Bedeutung der Menisken zur Arthroseverhinderung sollte bei jungen Patienten mit Meniskusläsion, die nicht refixiert oder sparsam reseziert werden können, eine Meniskustransplantation in Betracht gezogen werden. Bandstabilität und gerade Beinachsen sind dabei eine Voraussetzung. Das Vorliegen von fortgeschrittenen Knorpelveränderungen ist eine Kontraindikation. Die allogenen Meniskustransplantate entsprechen am ehesten den biomechanischen Anforderungen des originären Meniskus. Zumeist wird tiefgefrorenes Material verwendet. Das Risiko der Krankheitsübertragung muss als Komplikationsmöglichkeit genannt werden. Für die Meniskustransplantation werden offene und arthroskopisch assistierte Operationstechniken beschrieben. Wichtig für das Ergebnis der Meniskustransplantation sind die korrekte Größenbestimmung und Positionierung des Transplantatmeniskus sowie die sichere Fixierung am Vorder- und Hinterhorn. Publizierte Nachuntersuchungen zeigen, dass eine Schmerzreduktion und Funktionsverbesserung möglich sind. Größer angelegte Langzeitstudien, die beweisen, dass durch Meniskustransplantation die Entwicklung einer Arthrose verhindert werden kann, stehen noch aus.

Abstract

Loss of meniscal cartilage leads to degenerative arthritis. Therefore, it is important to save the meniscus whenever possible. But not all damaged menisci can be treated by partial resection or repair. The concept of meniscal transplantation has been suggested and has been become more common in recent years. Meniscal transplantation should be considered for the young patient who has not developed advanced osteoarthritis. Ligament stability and normal knee alignment are further requirements for meniscal transplantation. At this time, meniscal allografts provide the best a priori conditions to prevent degenerative arthritis, but the use of allografts includes the risk of disease transmission. Open and arthroscopically assisted techniques have been described. Correct size matching and positioning as well as secure fixation of the meniscal horn are important for successful meniscal allograft transplantation. Even though controlled clinical studies have not yet provided clear evidence that meniscal transplantation prevents degenerative arthritis, pain relief and functional improvement have been found in follow-up studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Arkel van ERA, Berg-Loonen van den EM, Wersch van JWJ et al. (1997) Human leukocyte antigen sensitization after cryopreserved human meniscal transplantations. Transplantation 64(3): 531–533

    Article  PubMed  Google Scholar 

  2. Arkel ERA van, de Boer HH (2002) Survival analysis of human meniscal Transplantations. J Bone Joint Surg Br 84(2): 227–231

    Article  PubMed  Google Scholar 

  3. Carter TR (1999) Meniscal allograft transplantation. Sports Med Arthrosc Rev 7(1): 51–62

    Article  Google Scholar 

  4. Chen MI, Branch TP, Hutton WC (1996) Is it important to secure the horns during lateral meniscal transplantation? A cadaveric study. Arthroscopy 12(2): 174–181

    PubMed  CAS  Google Scholar 

  5. Cole BJ, Dennis MG, Stephen J et al. (2006) Prospective evaluation of allograft meniscus transplantation. A minimum 2-Year follow-up. Am J Sports Med 34(6): 919–927

    Article  PubMed  Google Scholar 

  6. Dienst M, Greis PE, Ellis BJ et al. (2007) Effect of lateral meniscal allograft sizing on contact mechanics of the lateral tibial plateau: an experimental study in human cadaveric joints. Am J Sports Med 35(1): 34–42

    Article  PubMed  Google Scholar 

  7. Dienst M, Kohn D (2006) Allogenic meniscus transplantation. Oper Orthop Traumatol 18(5–6): 463–480

    Google Scholar 

  8. Donahue TL, Hull ML, Howell SM (2007) New algorithm for selecting meniscal allografts that best match the size and shape of the damaged meniscus. J Orthop Res 24(7): 1535–1543

    Article  Google Scholar 

  9. Fairbank TJ (1948) Knee joint changes after meniscectomy. J Bone Joint Surg Br 30: 664

    Google Scholar 

  10. Goble EM, Verdonk R, Kohn D (1999) Arthroscopic and open surgical techniques for meniscus replacement – meniscal allograft and tendon autograft transplantation. Scand J Med Sci Sports 9: 168–176

    PubMed  CAS  Google Scholar 

  11. Graf KW, Sekiya JK, Wojtys EM (2004) Long-Term results after combined medial meniscal allograft transplantation and anterior cruciate ligament reconstruction: minimum 8.5-Year follow-up study. Arthroscopy 20(2): 129–140

    Article  PubMed  Google Scholar 

  12. Kummer B (1994) Biomechanik des Meniskus. Orthopäde 23: 90–92

    PubMed  CAS  Google Scholar 

  13. Lazovic D, Wirth CJ, Sieg A et al. (1997) Effect of surgical technique on meniscal transplants. A histological, animal experiment study. Unfallchirurg 100(7): 541–546

    Article  PubMed  CAS  Google Scholar 

  14. Lubowitz JH, Verdonk PC, Reid JB 3rd, Verdonk R (2007) Meniscus allograft transplantation: a current concepts review. Knee Surg Sports Traumatol Arthrosc 15(5): 476–492

    Article  PubMed  Google Scholar 

  15. Matava MJ (2007) Meniscal allograft transplantation: a systematic review. Clin Orthop 455: 142–157

    Article  PubMed  Google Scholar 

  16. Noyes FR, Barber-Westin, SD, Rankin, M (2005) Meniscal transplantation in symptomatic patients less than fifty years old. J Bone Joint Surg Am 87A: 149–165

    Article  Google Scholar 

  17. Pollard ME, Kang Q, Berg EE (1995) Radiographic sizing for meniscal tranplantation. Arthroscopy 11(6): 684–687

    PubMed  CAS  Google Scholar 

  18. Rodeo SA (2001) Meniscal allografts – where do we stand? Am J Sports Med 29(2): 246–261

    PubMed  CAS  Google Scholar 

  19. Rodeo SA, Seneviratne A, Suzuki K et al. (2000) Histological analysis of human meniscal allografts. J Bone Joint Surg Am 82(8): 1071–1082

    PubMed  Google Scholar 

  20. Ryu RKN, Dunbar WH and Morse GG (2002) Meniscal allograft replacement: a 1-Year to 6 Year experience. Arthroscopy 18(9): 989–994

    PubMed  Google Scholar 

  21. Sekaran SV, Hull ML, Howell SM (2002) Nonanatomic location of the posterior horn of a medial meniscal autograft implanted in a cadaveric knee adversely affects pressure distribution on the tibial plateau. Am J Sports Med 30(1): 74–82

    PubMed  Google Scholar 

  22. Sekiya JK, Giffin JR, Irrgang JJ et al. (2003) Clinical outcomes after combined meniscal allograft transplantation and anterior cruciate ligament reconstruction. Am J Sports Med 31(6): 896–906

    PubMed  Google Scholar 

  23. Shaffer B (2000) Preoperative sizing of meniscal allografts in meniscus transplantation. Am J Sports Med 28(4): 524–533

    PubMed  CAS  Google Scholar 

  24. Stollsteimer GT, Shelton WR, Dukes A, Bomboy AL (2000) Meniscal allograft transplantation: a 1- to 5-Year follow-up of 22 patients. Arthroscopy 16(4): 343–347

    PubMed  CAS  Google Scholar 

  25. Verdonk P, Demurie A, Almqvist KF (2005) Transplantation of viable meniscal allograft. Surviviorship analysis and clinical outcome of one hundred cases. J Bone Joint Surg Am 87: 715–724

    Article  PubMed  Google Scholar 

  26. Verdonk P, Verstreate KL, Almqvist KF et al. (2006) Meniscal allograft transplantation: Long-Term clinical results with radiological and magnetic imaging correlations. Knee Surg Sports Traumatol Arthrosc 14(8): 694–706

    Article  PubMed  Google Scholar 

  27. von Lewinski G, Hurschler C, Allmann C, Wirth CJ (2006) The influence of pre-tensioning of meniscal transplants on the tibiofemoral contact area. Knee Surg Sports Traumatol Arthrosc 14(5): 425–436

    Article  Google Scholar 

  28. von Lewinski G, Kohn D, Milachowski KA et al. (2007) 20-Year results of combined medial meniscal allograft transplantation anterior cruciate ligament and advancement of the medial collateral ligament. Knee Surg Sports Traumatol Arthrosc 15(9): 1072–1082

    Article  Google Scholar 

  29. Wirth CJ, Peters G, Milachowski KA et al. (2002) Long-Term results of meniscal allograft transplantation. Am J Sports Med 30(2): 174–181

    PubMed  Google Scholar 

  30. Yoldas EA, Sekiya JK, Irrgang JJ et al. (2003) Arthroscopically assisted meniscal allograft transplantation with and without combined anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 11: 173–182

    PubMed  Google Scholar 

Download references

Interessenkonflikt

Keine Angaben

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G. Lewinski.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lewinski, G. Allogene Meniskustransplantation. Orthopäde 37, 743–748 (2008). https://doi.org/10.1007/s00132-008-1268-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00132-008-1268-7

Schlüsselwörter

Keywords

Navigation