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Pathophysiologie der posttraumatischen Osteitis

Pathophysiology of post-traumatic osteomyelitis

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Zusammenfassung

In den letzten Jahrzehnten gelang es durch Etablierung neuer Operationstechniken und -taktiken, durch an das Infektionsrisiko adaptierte Indikationsstellungen, durch Chemotherapeutika und durch neue Implantatentwicklungen die posttraumatische Infektionsrate deutlich zu minimieren. Hierbei waren neue Erkenntnisse über die pathophysiologischen Mechanismen der posttraumatischen und postoperativen Osteitis wegweisend. Trotzdem ziehen posttraumatische Infektionen weiterhin oftmals erhebliche gesundheitliche und ökonomische Folgen nach sich.

In diesem Artikel werden die wesentlichen pathophysiologischen Mechanismen der posttraumatischen Infektionsentstehung zusammengefasst. Es wird versucht, neue Denkanstöße zur posttraumatischen Osteitisprophylaxe und -therapie zu geben.

Abstract

Over the last few decades, significant reduction of post-traumatic infections could be attained by establishing novel surgical techniques and tactics, by adapting surgical decisions to the risk of infection, by employing chemotherapeutic agents, and by developing new implants. Here a novel understanding of the pathophysiologic mechanisms of post-traumatic and postoperative osteomyelitis were directive. Nevertheless, post-traumatic infections later cause significant physical and economic sequelae.

This article sums up the fundamental pathophysiological mechanisms of post-traumatic infection. New ideas about post-traumatic prevention and therapy of osteomyelitis are discussed.

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  1. BG-Kliniken Bergmannsheil, Chirurgische Klinik und Poliklinik, Universitätsklinik, Bochum

    T. Kälicke, F. Kutscha-Lissberg, T. M. Frangen, G. Muhr & S. Arens

  2. Berufsgenossenschaftliche Kliniken Bergmannsheil, Chirurgische Klinik und Poliklinik, Universitätsklinik, Bürkle-de-la-Camp-Platz 1, 44789, Bochum

    T. Kälicke

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  1. T. Kälicke
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  2. F. Kutscha-Lissberg
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Correspondence to T. Kälicke.

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Kälicke, T., Kutscha-Lissberg, F., Frangen, T.M. et al. Pathophysiologie der posttraumatischen Osteitis. Orthopäde 33, 405–411 (2004). https://doi.org/10.1007/s00132-003-0626-8

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