Zusammenfassung
Im vorliegenden Beitrag werden aktuelle Zulassungen und Indikationen zur Anwendung von Kontrastmitteln besprochen. Dies beinhaltet jodhaltige Kontrastmittel, Magnetresonanztomographiekontrastmittel und Ultraschallkontrastmittel. Unerwünschte allergische und renale Wirkungen werden diskutiert. Die Datenlage zur Medikation von Metformin bei Kontrastmittelgabe wird analysiert. Das Krankheitsbild der nephrogenen systemischen Fibrose (NSF) wird erläutert und die damit verbundene Datenlage bezüglich der verschiedenen Magnetresonanztomographiekontrastmittel wird dargestellt. Die aktuellen Änderungen der ESUR-Leitlinien (ESUR: „European Society of Urogenital Radiology“) werden ebenfalls präsentiert.
Abstract
The manuscript summarizes current approved contrast media and their indications. Contrast agents that are discussed include iodinated contrast agents, magnetic resonance (MR) contrast agents, and ultrasound contrast agents. Allergic and non-allergic renal adverse events are described. The clinical issue of metformin and the administration of contrast agents are updated. Nephrogenic systemic fibrosis (NSF) is discussed and safety issues of available MR contrast agents are analyzed. The most recent changes in European Society of Urogenital Radiology (ESUR) guidelines are also presented.
Literatur
Thomsen HS, Webb JA (Hrsg) (2012) ESUR guidelines on contrast media, Version 8.0. European Society of Urogenital Radiology, Wien. http://www.esur.org/guidelines/. Zugegriffen: 16.12.2012
Knopp MV, Balzer T, Esser M et al (2006) Assessment of utilization and pharmacovigilance based on spontaneous adverse event reporting of gadopentetate dimeglumine as a magnetic resonance contrast agent after 45 million administrations and 15 years of clinical use. Invest Radiol 41(6):491–499
Jung JW, Kang HR, Kim MH et al (2012) Immediate hypersensitivity reaction to gadolinium-based MR contrast media. Radiology 264(2):414–422
Hunt CH, Hartman RP, Hesley GK (2009) Frequency and severity of adverse effects of iodinated and gadolinium contrast materials: retrospective review of 456,930 doses. AJR Am J Roentgenol 193(4):1124–1127
Golder W ((2012) Kombinierter zeitnaher Einsatz jod- und gadoliniumhaltiger Kontrastmittel in der diagnostischen und interventionellen Radiologie. Ein bisher vernachlässigtes Kapitel der radiologischen Praxis. Radiologe 52:167–172
Kubik-Huch RA, Gottstein-Aalame NM, Frenzel T et al (2000) Gadopentetate dimeglumine excretion into human breast milk during lactation. Radiology 216(2):555–558
Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) – update 2008. Ultraschall Med 29(1):28–44
Bellin MF, Stacul F, Webb JA et al (2011) Late adverse reactions to intravascular iodine based contrast media: an update. Eur Radiol 21(11):2305–2310
Moan R (2012) ESUR updates guidelines to prevent NSF. AuntMinnieEurope, http://www.auntminnieeurope.com/index.aspx?sec=sup&sub=mri&pag=dis&ItemID=607058. Zugegriffen: 16.12.2012
Morcos SK, Thomsen HS, Webb JA (1999) Contrast-media-induced nephrotoxicity: a consensus report. Contrast Media Safety Committee, European Society of Urogenital Radiology (ESUR). Eur Radiol 9(8):1602–1613
Stacul F, Molen AJ van der, Reimer P et al (2011) Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines. Eur Radiol 21(12):2527–2541
Girardi M, Kay J, Elston DM et al (2011) Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations. J Am Acad Dermatol 65(6):1095–1106.e7
Vosshenrich R, Reimer P (2009) Nephrogenic systemic fibrosis. Vasa 38(1):31–38
Bennett CL, Qureshi ZP, Sartor AO et al (2012) Gadolinium-induced nephrogenic systemic fibrosis: the rise and fall of an iatrogenic disease. Clin Kidney J 5(1):82–88
Thomsen HS (2007) ESUR guideline: gadolinium-based contrast media and nephrogenic systemic fibrosis. Eur Radiol 17(10):2692–2696
Thomsen HS, Morcos SK, Almen T et al (2013) Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol 23(2):307–318
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Reimer, P., Vosshenrich, R. Kontrastmittel in der Radiologie . Radiologe 53, 153–164 (2013). https://doi.org/10.1007/s00117-012-2429-6
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DOI: https://doi.org/10.1007/s00117-012-2429-6