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Biomarker beim kindlichen Polytrauma

Biomarkers in pediatric polytrauma

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Zusammenfassung

Hintergrund

Das Trauma stellt bei Kindern eine der häufigsten Todesursachen dar. Neben einem vom Erwachsenen abweichenden Verletzungsmuster entwickeln Kinder im stationären Therapieverlauf zudem seltener eine Dysfunktion multipler Organsysteme („multiple organ dysfunction syndrome“, MODS). Des Weiteren tritt das kindliche MODS im Vergleich zum erwachsenen Patienten im posttraumatischen Therapieverlauf frühzeitiger auf.

Methode

Biomarker zur frühzeitigen Identifizierung von Risikopatienten für posttraumatische Komplikationen sind von hoher klinischer Relevanz. Trotz der Bedeutung des kindlichen Traumas finden sich in der Literatur allerdings nur eine begrenzte Anzahl klinischer Studien, die die Bedeutung verschiedener Biomarker beim Kind charakterisiert haben.

Ziel

In der vorliegenden Arbeit soll anhand von klinischen Studien hierzu der aktuelle Kenntnisstand zusammengefasst werden.

Abstract

Background

Trauma represents one of the leading causes of death in children. Beside an injury pattern that differs from adult trauma patients, children seem to develop multiple organ dysfunction syndrome (MODS) less frequently. Compared to adult MODS, pediatric MODS has also been described to occur earlier in the posttraumatic course.

Method

Biomarkers for early identification of patients at high-risk for posttraumatic complications are of high clinical relevance. However, little is known from clinical studies about the relevance of biomarkers during the posttraumatic course.

Aim

Therefore, the purpose of this review is to summarize current knowledge on this topic in order to investigate the prognostic significance of different parameters.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. H. Andruszkow, R. Pfeifer, K. Horst, P. Kobbe, H.-C. Pape und F. Hildebrand geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Unfall- und Wiederherstellungschirurgie und Harald Tscherne Forschungslabor, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    H. Andruszkow, R. Pfeifer, K. Horst, P. Kobbe, H.-C. Pape & F. Hildebrand

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  1. H. Andruszkow
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  2. R. Pfeifer
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  3. K. Horst
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  4. P. Kobbe
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  5. H.-C. Pape
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  6. F. Hildebrand
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Corresponding author

Correspondence to H. Andruszkow.

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Andruszkow, H., Pfeifer, R., Horst, K. et al. Biomarker beim kindlichen Polytrauma. Unfallchirurg 117, 679–685 (2014). https://doi.org/10.1007/s00113-013-2541-8

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  • DOI: https://doi.org/10.1007/s00113-013-2541-8

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