Zusammenfassung
Die perkutane präoperative Embolisation zur Behandlung von Tumoren des Glomus caroticum mit Ethylen-Vinylalkohol-Kopolymer (Onyx®) wurde erst vor kurzer Zeit im deutschsprachigen Raum eingeführt. Nach Direktpunktion des Tumors wurde Onyx® unter Angiographiekontrolle perkutan injiziert. Die postinterventionelle Angiographie zeigte eine vollständige Okklusion aller tumorversorgenden Gefäße. Im anschließenden chirurgischen Eingriff konnte der Tumor komplett komplikationslos entfernt werden. Die direkte perkutane Embolisation von Glomus-caroticum-Tumoren der Kopf-Hals-Region ist eine sichere und effektive präoperative Behandlungsmaßnahme mit geringer Komplikationsrate. Sie stellt eine neue Säule in der Behandlungsstrategie von Glomus-caroticum-Tumoren dar. Mit dieser Methode wird die Möglichkeit einer vollständigen Tumorresektion deutlich erhöht.
Abstract
Carotid body tumors are highly vascularized lesions that require successful preoperative embolization to achieve favorable clinical results in terms of morbidity and complete tumor resection. The procedure of percutaneous embolization was performed using ethylene-vinyl alcohol copolymer (Onyx) in addition to balloon-catheter protection to prevent particle displacement into the internal carotid artery. The procedure resulted in nearly complete tumor embolization and facilitated the uneventful complete surgical resection. Percutaneous angiographic embolization of carotid body tumors in the head and neck was found to be safe and effective. This technique is likely to result in improved surgical outcomes and tumor resectability.
Literatur
Bapuray JR, Mani NB, Khandelwal NK et al (1984) New parameter of hemoglobin status as an indicator of efficacy of preoperative angioembolization in extracranial hypervascular tumours. J Otolaryngol 31:313–316
Borba LA, Al-Mefty O (1996) Intravagal Paragangliomas: Report of four cases. Neurosurg 38:569–575
Boedeker CC, Ridder GJ, Neumann HP et al (2004) Diagnostik, Therapie und Behandlungsergebnisse zervikaler Paragangliome. Laryngorhinootologie 83:585–592
Briner HR, Linder TE, Pauw B, Fisch U (1999) Long-term results of surgery for temporal bone paragangliomas. Laryngoscope 109:577–583
Conley JJ (1970) Tumours of neurogenous origin: Concepts in Head and Neck surgery. Thieme, Stuttgart, pp 211–229
Cummings BJ, Beale FA, Garrett PG et al (1984) The treatment of glomus tumors in the temporal bone by Megavoltage Radiation. Cancer 53:2635–2640
Elhammady MS, Farhat H, Ziayee H, Aziz-Sultan MA (2009) Direct percutaneous embolization of a carotid body tumor with Onyx. J Neurosurg 110:124–127
Fisch U (1977) Mikrochirurgie des Os temporale. HNO 25:193–197
George B, Casasco A, Deffrennes D, Houdart E (1994) Intratumoral embolization of intracranial and extracranial tumors: Technical note. Neurosurgery 35:771–774
Girolami G, Heuser L, Hildmann H, Sudhoff H (2008) Präoperative Embolisation von Glomustumoren. Laryngorhinootologie 87:181–185
Glasgow GP, Sampiere VA, Purdy JA (1988) Patient registration and immobilization, Principles and practice of radiation oncology. Lippincott, Philadelphia, pp 161–162
Gore P, Theodore N, Brasiliense L et al (2008) The utility of onyx for preoperative embolization of cranial and spinal tumors. Neurosurg 62:1204–1212
Greess H, Bentzien S, Gjuric M et al (2000) Rezidivdiagnostik von Glomus-jugulare-Tumoren mittels dynamischer Kontrastmittel-Anflutung in der MRT. Rofo 172:753–758
Herdmann RCD, Gillespie JE, Ramsden RT (1993) Radiology in focus: Facial palsy after glomus tumor embolization. J Laryngol Otol 107:963–966
Hesselink JR, Davis KR, Taveras JM (1980) Selective arteriography of glomus tympanicum and jugulare tumors. AJNR Am J Neuroradiol 2:289–297
Hildmann H (1973) Die Glomustumoren des Mittelohrs. HNO 21:344–346
Jackson CG, Cueva RA, Thedinger BA (1991) Cranial nerve preservation in lesions if the jugular fossa. Otolaryngol Head Neck Surg 105:687–693
Jenkins HA, Fisch U (1981) Glomus tumors of the temporal region. Technique of surgical resection. Arch Otolaryngol 107:209–214
LaMuraglia GM, Fabian RL, Brewster DC et al (1992) The current surgical management of carotid body paragangliomas. J Vasc Surg 15:1038–1044
Murphy TP, Brackmann DE (1989) Effects of preoperative embolization on glomus jugulare tumors. Laryngoscope 99:1244–1247
Quadros RS, Gallas S, Delcourt C et al (2006) Preoperative embolization of a cervicodorsal paraganglioma by direct percutaneous injection of onyx and endovascular delivery of particles. AJNR Am J Neuroradiol 27:1907–1909
Schirmer CM, Zerris V, Malek AM (2006) Electrocautery-induced ignition of spark showers and self-sustained combustion of onyx ethylene-vinyl alcohol copolymer. Neurosurgery 59(4 Suppl 2)
Tadavarthy SM, Moller JH, Amplatz K (1975) Polyvinyl alcohol (Ivalon) - a new embolic material. Am J Roentgenol Radium Ther Nucl Med 125:609–616
Valavanis A, Christoforidis G (2000) Applications of interventional neuroradiology in the head and neck. Semin Roentgenol 35:72–83
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ulrich, S., Lehmann, M., Ebmeyer, J. et al. Perkutane Onyx®-Embolisation zur Therapie von Glomus-caroticum-Tumoren. HNO 57, 1305–1310 (2009). https://doi.org/10.1007/s00106-009-1960-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00106-009-1960-x
Schlüsselwörter
- Glomus-caroticum-Tumor
- Ethylen-Vinylalkohol-Kopolymer (Onyx®)
- Perkutane Embolisation
- Glomustumor
- Paragangliom