Skip to main content
SpringerLink
Log in

Leishmaniasis

Diagnostik und Therapie

Leishmaniasis

Diagnosis and therapy

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Das zeitlich verzögerte Auftreten einer Papel nach einem Auslandsaufenthalt kann auf das Vorliegen einer kutanen Leishmaniasis hinweisen. Histologisch zeigt sich eine granulomatöse Entzündungsreaktion, in den Histiozyten findet man in der Giemsa-Färbung intrazelluläre Parasiten. Mittels Polymerasekettenreaktion aus dem Gewebe oder der Kultur lassen sich potenzielle Differenzialdiagnosen ausschließen, aber auch die Leishmania-Subspezies identifizieren. Letzteres ist wichtig für die Wahl des optimalen Therapieregimes.

Abstract

The delayed appearance of a papule after returning from travelling hints towards the diagnosis cutaneous leishmaniasis. Histologically, a granulomatous inflammatory response is seen, and using Giemsa staining, intracellular parasites can be visualized within histiocytes. Polymer chain reaction (PCR) from the tissue or subsequent cultures not only aids in excluding other differential diagnoses, but also in the identification of the causing Leishmania subspecies. The latter is important for the choice of the optimal therapeutic regimen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Butsch F, Faulde M, Debus A, Bogdan C, von Stebut E (2013) Two cases of successful treatment of multilesional cutaneous leishmaniasis with liposomal amphotericin B. J Dtsch Dermatol Ges 11:83–85

    PubMed  Google Scholar 

  2. Boecken G, Sunderkötter C, Bogdan C et al (2011) Diagnosis and therapy of cutaneous and mucocutaneous Leishmaniasis in Germany. J Dtsch Dermatol Ges 9(Suppl 8):1–51

    Article  PubMed  Google Scholar 

  3. Butsch F, Lorenz B, Goldinger A, von Stebut E (2016) Topical treatment with a two-component gel releasing nitric oxide cures C57BL/6 mice from cutaneous leishmaniasis caused by Leishmania major. Exp Dermatol 25(11):914–916

    Article  CAS  PubMed  Google Scholar 

  4. Geiger B, Wenzel J, Hantschke M, Haase I, Ständer S, von Stebut E (2010) Resolving lesions in human cutaneous leishmaniasis predominantly harbour chemokine receptor CXCR3-positive T helper 1/T cytotoxic type 1 cells. Br J Dermatol 162(4):870–874

    Article  CAS  PubMed  Google Scholar 

  5. Ngouateu OB, Kollo P, Ravel C, Dereure J, Kamtchouing P, Same-Ekobo A, von Stebut E, Maurer M, Dondji B (2012) Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major/HIV co-infection in Cameroon: results of a large cross-sectional study. Trans R Soc Trop Med Hyg 106(3):137–142

    Article  PubMed  Google Scholar 

  6. Stahl HC, Ahmadi F, Schleicher U et al (2014) A randomized controlled phase IIb wound healing trial of cutaneous leishmaniasis ulcers with 0.045 % pharmaceutical chlorite (DAC N‑055) with and without bipolar high frequency electro-cauterization versus intralesional antimony in Afghanistan. BMC Infect Dis 14:619

    Article  PubMed  PubMed Central  Google Scholar 

  7. von Stebut E, Boecken G, Sunderkötter C, Bogdan C (2016) Importierte Dermatose: Kutane Leishmaniasis. Dtsch Arztebl 15:A717–A720

    Google Scholar 

  8. von Stebut E, Schleicher U, Bogdan C (2012) Cutaneous leishmaniasis as travelers’ disease. Clinical presentation, diagnostics and therapy. Hautarzt 63(3):233–248

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hautklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland

    E. von Stebut

Authors
  1. E. von Stebut
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. von Stebut.

Ethics declarations

Interessenkonflikt

E. von Stebut gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

von Stebut, E. Leishmaniasis. Hautarzt 68, 548–552 (2017). https://doi.org/10.1007/s00105-017-4001-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-017-4001-9

Schlüsselwörter

Keywords

Search

Navigation