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Endogene Faktoren, Gene und Hautalterung

Intrinsic factors, genes, and skin aging

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Zusammenfassung

Hautalterung wird durch eine Kombination von endogenen Faktoren und Umwelteinflüssen bestimmt, die unter anderem epigenetische, posttranslationale, mikrobielle und Lifestyle-Faktoren beinhalten. Insbesondere spielen genetische Änderungen, vorprogrammiert oder nicht, eine zentrale Rolle, und das Verständnis dieser komplexen Mechanismen kann zur Prävention von altersbedingten Krankheiten und zur Verlängerung der gesunden Lebensspanne beitragen. In diesem Artikel sind neue Erkenntnisse über Gene und biologische Prozesse zusammengefasst, die die Hauthomöostase im Alter signifikant beeinflussen können und zu den typischen morphologischen und physiologischen Merkmalen der alternden Haut führen können.

Abstract

Skin aging is determined by a combination of endogenous and environmental influences, including epigenetic, posttranslational, microbial, and lifestyle factors. In particular genetic changes, programmed or not, play a pivotal role and understanding of these complex mechanisms may contribute to the prevention of age-related diseases and extension of healthy lifespan. In this article, new knowledge about genes and biological processes that can significantly affect skin homeostasis in old age and can lead to the typical morphological and physiological characteristics of aging skin are summarized.

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Literatur

  1. Breitenbach JS, Rinnerthaler M, Trost A, Weber M, Klausegger A, Gruber C, Bruckner D, Reitsamer HA, Bauer JW, Breitenbach M (2015) Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging. Aging (Albany NY) 7:389–411

    Google Scholar 

  2. Brun C, Jean-Louis F, Oddos T, Bagot M, Bensussan A, Michel L (2015) Phenotypic and functional changes in dermal primary fibroblasts isolated from intrinsically aged human skin. Exp Dermatol. doi:10.1111/exd.12874

  3. Burtner CR, Kennedy BK (2010) Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol 11:567–578

    Article  CAS  PubMed  Google Scholar 

  4. Chondrogianni N, Voutetakis K, Kapetanou M, Delitsikou V, Papaevgeniou N, Sakellari M, Lefaki M, Filippopoulou K, Gonos ES (2015) Proteasome activation: an innovative promising approach for delaying aging and retarding age-related diseases. Ageing Res Rev 23:37–55

    Article  CAS  PubMed  Google Scholar 

  5. Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE (2013) Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays 35:386–396

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Elewa R, Makrantonaki E, Zouboulis CC (2013) Neuropeptides and skin aging. Horm Mol Biol Clin Investig 16:29–33

    CAS  PubMed  Google Scholar 

  7. Farage M, Miller KW, Zouboulis CC, Pierard G, Maibach HM (2012) Sex steroid hormones and gender differences in skin aging. J Steroid Horm Sci 3:109

    Article  Google Scholar 

  8. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span – from yeast to humans. Science 328:321–326

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Gilchrest BA, Campisi J, Chang HY, Fisher GJ, Kulesz-Martin MF (2015) Montagna Symposium 2014-skin aging: molecular mechanisms and tissue consequences. J Invest Dermatol 135:950–953

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Gronniger E, Weber B, Heil O, Peters N, Stab F, Wenck H, Korn B, Winnefeld M, Lyko F (2010) Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet 6:e1000971

    Article  PubMed Central  PubMed  Google Scholar 

  11. Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol 14:R115

    Article  PubMed Central  PubMed  Google Scholar 

  12. Jung M, Pfeifer GP (2015) Aging and DNA methylation. BMC Biol 13:7

    Article  PubMed Central  PubMed  Google Scholar 

  13. Jung M, Jin SG, Zhang X, Xiong W, Gogoshin G, Rodin AS, Pfeifer GP (2015) Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging. Nucleic Acids Res 43:e100

    Article  PubMed Central  PubMed  Google Scholar 

  14. Kamenisch Y, Berneburg M (2009) Progeroid syndromes and UV-induced oxidative DNA damage. J Investig Dermatol Symp Proc 14:8–14

    Article  CAS  PubMed  Google Scholar 

  15. Kennedy SR, Loeb LA, Herr AJ (2012) Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev 133:118–126

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Koch S, Garcia Gonzalez O, Assfalg R, Schelling A, Schafer P, Scharffetter-Kochanek K, Iben S (2014) Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth. Cell Cycle 13:2029–2037

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Lener T, Moll PR, Rinnerthaler M, Bauer J, Aberger F, Richter K (2006) Expression profiling of aging in the human skin. Exp Gerontol 41:387–397

    Article  CAS  PubMed  Google Scholar 

  18. Makrantonaki E, Zouboulis CC (2007) William J. Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 214:352–360

    Article  PubMed  Google Scholar 

  19. Makrantonaki E, Bekou V, Zouboulis CC (2012) Genetics and skin aging. Dermatoendocrinol 4:280–284

    Article  PubMed Central  PubMed  Google Scholar 

  20. Makrantonaki E, Brink TC, Zampeli V et al (2012) Identification of biomarkers of human skin ageing in both genders. Wnt signalling – a label of skin ageing? PLoS One 7:e50393

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Makrantonaki E, Vogel M, Scharffetter-Kochanek K, Zouboulis CC (2015) Hautalterung – Molekulares Verständnis der ex- und intrinsischen Vorgänge. Hautarzt 66:730–737

    Article  CAS  PubMed  Google Scholar 

  22. Mohrin M, Chen D (2013) Sirtuins, tissue maintenance, and tumorigenesis. Genes Cancer 4:76–81

    Article  PubMed Central  PubMed  Google Scholar 

  23. Nikolakis G, Makrantonaki E, Zouboulis CC (2013) Skin mirrors human ageing. Horm Mol Biol Clin Investig 16:13–28

    CAS  PubMed  Google Scholar 

  24. Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC (2012) Discovering the link between nutrition and skin aging. Dermatoendocrinol 4:298–307

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Waldera Lupa DM, Kalfalah F, Safferling K et al (2015) Characterization of skin aging-associated secreted proteins (SAASP) produced by dermal fibroblasts isolated from intrinsically aged human skin. J Invest Dermatol 135:1954–1968

    Article  CAS  PubMed  Google Scholar 

  26. Zouboulis CC (2015) Wie vergänglich ist Schönheit? Endogene und exogene Faktoren der Hautalterung und Aspekte der optimalen Nährstoffversorgung und Pflege. Aktuel Ernahrungsmed 40(Suppl 1):S27–S31

    Google Scholar 

  27. Zouboulis CC, Makrantonaki E (2011) Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol 29:3–14

    Article  PubMed  Google Scholar 

  28. Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann K (2008) Human skin stem cells and the ageing process. Exp Gerontol 43:986–997

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein Allee 23, Life Sciences Building N27, James-Franck Ring/ Meyerhofstr. 11c, 89081, Ulm, Deutschland

    E. Makrantonaki

  2. Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06487, Dessau, Deutschland

    E. Makrantonaki &  C. C. Zouboulis

  3. Center for Epigenetics, Van Andel Research Institute, 333 Bostwick Avenue NE, 49503, Grand Rapids, MI, USA

    G. P. Pfeifer

Authors
  1. E. Makrantonaki
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  2. G. P. Pfeifer
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  3. C. C. Zouboulis
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Corresponding author

Correspondence to C. C. Zouboulis.

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E. Makrantonaki, G.P. Pfeifer und C.C. Zouboulis geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Makrantonaki, E., Pfeifer, G.P. & Zouboulis, C.C. Endogene Faktoren, Gene und Hautalterung. Hautarzt 67, 103–106 (2016). https://doi.org/10.1007/s00105-015-3746-2

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  • DOI: https://doi.org/10.1007/s00105-015-3746-2

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