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Personalisierte Hirntumorchirurgie mittels intraoperativer stimulierter Raman-Histologie

Intraoperative stimulated Raman histology for personalized brain tumor surgery

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Zusammenfassung

Hintergrund

Ein individualisiertes chirurgisches Vorgehen ist in der Hirntumorchirurgie zum Erreichen einer maximal sicheren Resektion essenziell. Die Radikalität der Resektion ist maßgeblich abhängig von der histologischen Diagnose. Die stimulierte Raman-Histologie (SRH), eine laserbasierte optische Bildgebung, bietet die Möglichkeit der Erhebung einer intraoperativen Diagnose in wenigen Minuten.

Ziel der Arbeit

Überblick über die Anwendung von SRH in der Neurochirurgie und Übertragung der Technik auf weitere chirurgische Disziplinen.

Methoden

Beschreibung der Technik und Zusammenfassung der aktuellen Literatur zu SRH.

Ergebnisse

SRH konnte erfolgreich bei multiplen neuroonkologischen Tumorentitäten angewendet werden. Erste Pilotprojekte zeigen Potenzial zur Analyse extrazerebraler Tumoren auf.

Zusammenfassung

SRH ermöglicht eine Echtzeitdiagnose mit hoher diagnostischer Genauigkeit und bietet weiteres Entwicklungspotenzial zur Verbesserung der personalisierten Tumorchirurgie.

Abstract

Background

In brain tumor surgery a personalized surgical approach is crucial to achieve a maximum safe tumor resection. The extent of resection decisively depends on the histological diagnosis. Stimulated Raman histology (SRH), a fiber laser-based optical imaging method, offers the possibility for evaluation of an intraoperative diagnosis in a few minutes.

Objective

To provide an overview on the applications of SRH in neurosurgery and transference of the technique to other surgical disciplines.

Methods

Description of the technique and review of the current literature on SRH.

Results

The SRH technique was successfully used in multiple neuro-oncological tumor entities. Initial pilot projects showed the potential for analysis of extracranial tumors.

Conclusion

The use of SRH provides a near real-time diagnosis with high diagnostic accuracy and provides further developmental potential to improve personalized tumor surgery.

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Authors and Affiliations

  1. Klinik für allgemeine Neurochirurgie, Zentrum für Neurochirurgie, Medizinische Fakultät und Universitätsklinik Köln, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland

    Anna-Katharina Meißner,  Roland Goldbrunner &  Volker Neuschmelting

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  1. Anna-Katharina Meißner
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  2. Roland Goldbrunner
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  3. Volker Neuschmelting
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Corresponding author

Correspondence to Volker Neuschmelting.

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Interessenkonflikt

A.-K. Meißner, R. Goldbrunner und V. Neuschmelting geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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C. Bruns, Köln

T. Schmidt, Köln

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Meißner, AK., Goldbrunner, R. & Neuschmelting, V. Personalisierte Hirntumorchirurgie mittels intraoperativer stimulierter Raman-Histologie. Chirurgie 95, 274–279 (2024). https://doi.org/10.1007/s00104-024-02038-5

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