Skip to main content
Log in

Organprotektive Intensivtherapie und Simulatortraining

Organ protective intensive care treatment and simulation-based training

  • Intensivmedizin
  • Published:
Der Anaesthesist Aims and scope Submit manuscript

Zusammenfassung

Die Bereitschaft zur Organspende ist in Deutschland nach wie vor unzureichend. Bei Weitem nicht alle Patienten auf den Wartelisten erhalten rechtzeitig ein geeignetes Spenderorgan. Die adäquate intensivmedizinische Versorgung des Organspenders ist bislang in Lösungsansätzen dieses Problems wenig beachtet worden. Bei zunehmendem Alter und zunehmender Komorbidität ist eine adäquate intensivmedizinische Therapie des Spenders für den Erfolg der möglichen Transplantationen unabdingbar. Randomisierte klinische Studien zur organprotektiven Therapie sind jedoch nicht ausreichend verfügbar. Die vorliegende Übersicht fasst die aktuelle wissenschaftliche Literatur zusammen und gibt einen Ausblick auf Lösungsansätze. Dabei könnten die Durchführung multizentrischer Studien sowie die intensivierte Aus- und Weiterbildung von ärztlichem und pflegerischem Intensivpersonal erste wesentliche Schritte sein, diesen Zustand zu verbessern. Auch die Weiterentwicklung und Etablierung curricularer Fortbildungen an Simulatoren ist ein vielversprechender Ansatz zur quantitativen und qualitativen Steigerung der Organspende.

Abstract

In Germany the extent of organ donation is still inadequate and not sufficient to address patients on the waiting lists. Nevertheless, intensive care treatment of potential organ donors does not receive adequate attention. However, because of the increasing age and comorbidities of organ donors in recent years, a sufficient intensive care treatment is indispensable for the success of organ transplantations. Sufficient randomized clinical trials are lacking. This article reviews the current literature and describes approaches for improvement. Multicentre studies and education of medical staff of intensive care units, for example in intensive care simulation for organ protection, could potentially be a successful approach. The improvement and establishment of curricular training and education particularly in simulation workshops might be a promising approach to enhance the quantity and quality of organ donations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Angel LF, Levine DJ, Restrepo MI et al (2006) Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes. Am J Respir Crit Care Med 174:710–716

    Article  PubMed  Google Scholar 

  2. Audibert G, Charpentier C, Seguin-Devaux C et al (2006) Improvement of donor myocardial function after treatment of autonomic storm during brain death. Transplantation 82:1031–1036

    Article  PubMed  CAS  Google Scholar 

  3. Avlonitis VS, Wigfield CH, Kirby JA et al (2005) The hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant 5:684–693

    Article  PubMed  Google Scholar 

  4. Benck U, Gottmann U, Hoeger S et al (2011) Donor desmopressin is associated with superior graft survival after kidney transplantation. Transplantation 92:1252–1258

    Article  PubMed  CAS  Google Scholar 

  5. Benck U, Hoeger S, Brinkkoetter PT et al (2011) Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trial. J Am Coll Cardiol 58:1768–1777

    Article  PubMed  CAS  Google Scholar 

  6. Blasco V, Leone M, Antonini F et al (2008) Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation. Br J Anaesth 100:504–508

    Article  PubMed  CAS  Google Scholar 

  7. Botha P, Rostron AJ, Fisher AJ et al (2008) Current strategies in donor selection and management. Semin Thorac Cardiovasc Surg 20:143–151

    Article  PubMed  Google Scholar 

  8. Boulet JR, Murray DJ (2010) Simulation-based assessment in anesthesiology: requirements for practical implementation. Anesthesiology 112:1041–1052

    Article  PubMed  Google Scholar 

  9. Breuer G, Riss R, Schroder T et al (2004) „The intensive care simulator“: a new teaching-concept to train severe sepsis management. Dtsch Med Wochenschr 129:2586–2589

    Article  PubMed  CAS  Google Scholar 

  10. Bugge JF (2009) Brain death and its implications for management of the potential organ donor. Acta Anaesthesiol Scand 53:1239–1250

    Article  PubMed  CAS  Google Scholar 

  11. Chen EP, Bittner HB, Kendall SW et al (1996) Hormonal and hemodynamic changes in a validated animal model of brain death. Crit Care Med 24:1352–1359

    Article  PubMed  CAS  Google Scholar 

  12. Cipolla J, Stawicki S, Spatz D (2006) Hemodynamic monitoring of organ donors: a novel use of the esophageal echo-Doppler probe. Am Surg 72:500–504

    PubMed  Google Scholar 

  13. Cittanova Ml, Leblanc I, Legendre C et al (1996) Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients. Lancet 348:1620–1622

    Article  PubMed  CAS  Google Scholar 

  14. Cooke JM, Larsen J, Hamstra SJ et al (2008) Simulation enhances resident confidence in critical care and procedural skills. Fam Med 40:165–167

    PubMed  Google Scholar 

  15. Cooper JB, Taqueti VR (2004) A brief history of the development of mannequin simulators for clinical education and training. Qual Saf Health Care 13(Suppl 1):i11–18

    Article  PubMed  Google Scholar 

  16. Cumin D, Merry AF (2007) Simulators for use in anaesthesia. Anaesthesia 62:151–162

    Article  PubMed  CAS  Google Scholar 

  17. Deutsche Stiftung Organtransplantation (2011) Jahresstatistik 2010

  18. Dictus C, Vienenkoetter B, Esmaeilzadeh M et al (2009) Critical care management of potential organ donors: our current standard. Clin Transplant 23(Suppl 21):2–9

    Article  PubMed  Google Scholar 

  19. Dimopoulou I, Tsagarakis S, Anthi A et al (2003) High prevalence of decreased cortisol reserve in brain-dead potential organ donors. Crit Care Med 31:1113–1117

    Article  PubMed  CAS  Google Scholar 

  20. Dso (2003) Deutsche Stiftung Organtransplantation, Informationsordner, 2. Aufl.,S 44–52, http://www.dso.de, 19.12.2011

  21. Dso (2011) Deutsche Stiftung Organtransplantation, Organspende und Transplantation in Deutschland, Jahresbericht 2010. Frankfurt

  22. Figueras J, Busquets J, Grande L et al (1996) The deleterious effect of donor high plasma sodium and extended preservation in liver transplantation. A multivariate analysis. Transplantation 61:410–413

    Article  PubMed  CAS  Google Scholar 

  23. Follette DM, Rudich SM, Babcock WD (1998) Improved oxygenation and increased lung donor recovery with high-dose steroid administration after brain death. J Heart Lung Transplant 17:423–429

    PubMed  CAS  Google Scholar 

  24. Gaba DM (1995) Anaesthesia simulators. Can J Anaesth 42:952–953

    Article  PubMed  CAS  Google Scholar 

  25. Gabbay E, Williams TJ, Griffiths AP et al (1999) Maximizing the utilization of donor organs offered for lung transplantation. Am J Respir Crit Care Med 160:265–271

    PubMed  CAS  Google Scholar 

  26. Gonzalez FX, Rimola A, Grande L et al (1994) Predictive factors of early postoperative graft function in human liver transplantation. Hepatology 20:565–573

    PubMed  CAS  Google Scholar 

  27. Good Ml, Gravenstein JS (1989) Anesthesia simulators and training devices. Int Anesthesiol Clin 27:161–168

    Article  PubMed  CAS  Google Scholar 

  28. Gramm HJ, Meinhold H, Bickel U et al (1992) Acute endocrine failure after brain death? Transplantation 54:851–857

    Article  PubMed  CAS  Google Scholar 

  29. Halejcio-Delophont P, Siaghy EM, Devaux Y et al (1998) Increase in myocardial interstitial adenosine and net lactate production in brain-dead pigs: an in vivo microdialysis study. Transplantation 66:1278–1284

    Article  PubMed  CAS  Google Scholar 

  30. Heuer M, Hertel S, Remmer N et al (2009) Readiness for organ donation: analysis of a survey for health themes. Dtsch Med Wochenschr 134:923–926

    Article  PubMed  CAS  Google Scholar 

  31. Hevesi ZG, Lopukhin SY, Angelini G et al (2006) Supportive care after brain death for the donor candidate. Int Anesthesiol Clin 44:21–34

    Article  PubMed  Google Scholar 

  32. Howlett TA, Keogh AM, Perry L et al (1989) Anterior and posterior pituitary function in brain-stem-dead donors. A possible role for hormonal replacement therapy. Transplantation 47:828–834

    Article  PubMed  CAS  Google Scholar 

  33. Ketzler K (1996) Organ donation in Germany. Langenbecks Arch Chir Suppl Kongressbd 113:376–379

    PubMed  CAS  Google Scholar 

  34. Kuecuek O, Mantouvalou L, Klemz R et al (2005) Significant reduction of proinflammatory cytokines by treatment of the brain-dead donor. Transplant Proc 37:387–388

    Article  PubMed  CAS  Google Scholar 

  35. Kutsogiannis DJ, Pagliarello G, Doig C et al (2006) Medical management to optimize donor organ potential: review of the literature. Can J Anaesth 53:820–830

    Article  PubMed  Google Scholar 

  36. Lam G, Ayas NT, Griesdale DE et al (2010) Medical simulation in respiratory and critical care medicine. Lung 188(6):445–457

    Article  PubMed  Google Scholar 

  37. Li J, Konstantinov IE, Cai S et al (2007) Systemic and myocardial oxygen transport responses to brain death in pigs. Transplant Proc 39:21–26

    Article  PubMed  Google Scholar 

  38. Lighthall GK, Barr J (2007) The use of clinical simulation systems to train critical care physicians. J Intensive Care Med 22:257–269

    Article  PubMed  Google Scholar 

  39. Marshall Rl, Smith JS, Gorman PJ et al (2001) Use of a human patient simulator in the development of resident trauma management skills. J Trauma 51:17–21

    Article  PubMed  CAS  Google Scholar 

  40. Marx G, Reinhart K (2006) Venous oximetry. Curr Opin Crit Care 12:263–268

    Article  PubMed  Google Scholar 

  41. Mascia L, Andrews PJ (1998) Acute lung injury in head trauma patients. Intensive Care Med 24:1115–1116

    Article  PubMed  CAS  Google Scholar 

  42. Mascia L, Mastromauro I, Viberti S et al (2009) Management to optimize organ procurement in brain dead donors. Minerva Anestesiol 75:125–133

    PubMed  CAS  Google Scholar 

  43. Mascia L, Pasero D, Slutsky AS et al (2010) Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA 304:2620–2627

    Article  PubMed  CAS  Google Scholar 

  44. McGaghie WC, Issenberg SB, Petrusa ER, Scalese RJ (2010) A critical review of simulation-based medical education research: 2003–2009. Med Educ 44:50–63

    Article  PubMed  Google Scholar 

  45. McGaghie WC, Issenberg SB, Petrusa ER, Scalese RJ (2006) Effect of practice on standardised learning outcomes in simulation-based medical education. Med Educ 40:792–797

    Article  PubMed  Google Scholar 

  46. McKeating EG, Andrews PJ, Signorini DF, Mascia L (1997) Transcranial cytokine gradients in patients requiring intensive care after acute brain injury. Br J Anaesth 78:520–523

    PubMed  CAS  Google Scholar 

  47. Meti (2010) http://www.meti.com. In, USA, Sarasota, FL, 34240

  48. Murray D (2005) Clinical simulation: measuring the efficacy of training. Curr Opin Anaesthesiol 18:645–648

    Article  PubMed  Google Scholar 

  49. Novitzky D, Cooper DK, Rosendale JD, Kauffman HM (2006) Hormonal therapy of the brain-dead organ donor: experimental and clinical studies. Transplantation 82:1396–1401

    Article  PubMed  CAS  Google Scholar 

  50. Okuda Y, Bryson EO, Demaria S Jr et al (2009) The utility of simulation in medical education: what is the evidence? Mt Sinai J Med 76:330–343

    Article  PubMed  Google Scholar 

  51. Pennefather SH, Bullock RE, Mantle D, Dark JH (1995) Use of low dose arginine vasopressin to support brain-dead organ donors. Transplantation 59:58–62

    Article  PubMed  CAS  Google Scholar 

  52. Pratschke J, Kofla G, Wilhelm MJ et al (2001) Improvements in early behavior of rat kidney allografts after treatment of the brain-dead donor. Ann Surg 234:732–740

    Article  PubMed  CAS  Google Scholar 

  53. Rey JW, Backhaus E, Wirges U, Hesse A (2010) The process of organ donation: nurses are assigned a key role. Pflege Z 63:652–656

    PubMed  Google Scholar 

  54. Rey JW, Barreiros AP, Teufel A et al (2009) Organmangel in Deutschland – Probleme und Perspektiven. Gastroenterologe 4:573–575

    Article  Google Scholar 

  55. Rey JW, Grass V, Barreiros AP et al (2012) Organ procurement in Germany – a regional survey among students. Dtsch Med Wochenschr 137:69–73

    Article  PubMed  CAS  Google Scholar 

  56. Rosendale JD, Kauffman HM, McBride MA et al (2003) Aggressive pharmacologic donor management results in more transplanted organs. Transplantation 75:482–487

    Article  PubMed  Google Scholar 

  57. Safar P, Escarraga LA, Elam JO (1958) A comparison of the mouth-to-mouth and mouth-to-airway methods of artificial respiration with the chest-pressure arm-lift methods. N Engl J Med 258:671–677

    Article  PubMed  CAS  Google Scholar 

  58. Schnuelle P, Gottmann U, Hoeger S et al (2009) Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial. JAMA 302:1067–1075

    Article  PubMed  CAS  Google Scholar 

  59. Shah VR (2008) Aggressive management of multiorgan donor. Transplant Proc 40:1087–1090

    Article  PubMed  CAS  Google Scholar 

  60. Siegmund-Schultze N (2011) Neue Diskussion über Organspende. Dtsch Arztebl 108(9):A-442/B-354/C-354

    Google Scholar 

  61. Silverstein JH (2010) Donor dopamine pretreatment and graft function after kidney transplantation. JAMA 303:230 (author reply 231–232)

    Article  PubMed  CAS  Google Scholar 

  62. Smith M (2004) Physiologic changes during brain stem death–lessons for management of the organ donor. J Heart Lung Transplant 23:217–222

    Article  Google Scholar 

  63. Steadman RH, Coates WC, Huang YM et al (2006) Simulation-based training is superior to problem-based learning for the acquisition of critical assessment and management skills. Crit Care Med 34:151–157

    Article  PubMed  Google Scholar 

  64. Tuttle-Newhall JE, Collins BH, Kuo PC et al (2003) Organ donation and treatment of the multi-organ donor. Curr Probl Surg 40:266–310

    Article  PubMed  Google Scholar 

  65. Ullah S, Zabala L, Watkins B et al (2006) Cardiac organ donor management. Perfusion 21:93–98

    Article  PubMed  Google Scholar 

  66. Venkateswaran RV, Dronavalli V, Lambert PA et al (2009) The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy. Transplantation 88:582–588

    Article  PubMed  CAS  Google Scholar 

  67. Venkateswaran RV, Patchell VB, Wilson IC et al (2008) Early donor management increases the retrieval rate of lungs for transplantation. Ann Thorac Surg 85:278–286 (discussion 286)

    Article  PubMed  Google Scholar 

  68. Venkateswaran RV, Steeds RP, Quinn DW et al (2009) The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double-blind factorially designed controlled trial. Eur Heart J 30:1771–1780

    Article  PubMed  CAS  Google Scholar 

  69. Wood KE, Becker BN, McCartney JG et al (2004) Care of the potential organ donor. N Engl J Med 351:2730–2739

    Article  PubMed  CAS  Google Scholar 

  70. Zaroff JG, Rosengard BR, Armstrong WF et al (2002) Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28–29, 2001, Crystal City, Va. Circulation 106:836–841

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J.W. Rey.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rey, J., Ott, T., Bösebeck, D. et al. Organprotektive Intensivtherapie und Simulatortraining. Anaesthesist 61, 242–248 (2012). https://doi.org/10.1007/s00101-012-1990-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00101-012-1990-8

Schlüsselwörter

Keywords

Navigation