Skip to main content
SpringerLink
Log in

Neue Überlegungen zu Entzündung und Gerinnung

New reflections on inflammation and coagulation

  • Medizin aktuell
  • Published:
Der Anaesthesist Aims and scope Submit manuscript

Zusammenfassung

Entzündung ist der Abwehrmechanismus des Wirtes gegen Infektionen oder Traumata. In der Klinik spielen nichtinfektiöse Entzündungen, eine Aktivierung der Gerinnungskaskade sowie eine Verschlechterung der endothelialen Funktion eine wichtige Rolle in der Kardiologie (z. B. bei der perkutanen transluminalen koronaren Angioplastie, PTCA), in der Intensivmedizin (z. B. beim Polytrauma), Herz- (z. B. bei der extrakorporalen Zirkulation) und Gefäßchirurgie (z. B. bei Reperfusionverletzung). Entgleiste Entzündungen sind hauptverantwortlich für den oft fatalen Verlauf von Krankheiten wie Herzinfarkt, Sepsis, hämorrhagisches Fieber (Ebola, Dengue), Organabstoßung und Autoimmunerkrankungen. Weltweit werden große Anstrengungen unternommen, die Regulation der Entzündung zu verstehen, um letztlich Medikamente zu entwickeln, die die pathologische Entzündungsreaktion modulieren können.

Abstract

Inflammation is the host’s defense mechanism to infection or injury, including surgical procedures. In the clinical setting non-infectious inflammation, activation of the coagulation cascade and deterioration of endothelial function play an important role in cardiology (e.g. percutaneous transluminal coronary angioplasty, PTCA), intensive care medicine (e.g. polytrauma), cardiac (e.g. extracorporal circulation) and vascular surgery (e.g. reperfusion injury). Imbalances in the inflammatory response are mainly responsible for the often fatal course in conditions such as myocardial infarction, sepsis, hemorrhagic fever (ebola, dengue), graft rejection and autoimmune diseases. Great efforts are being undertaken worldwide to understand the regulation of inflammation in order to develop new drugs which can modulate the pathologic inflammation reaction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Petzelbauer P, Zacharowski P, Friedl P et al. (2005) The peptide Bβ15–42 protects the myocardium against ischemia/reperfusion injury. Nat Med 11(3): 298–304

    Article  PubMed  Google Scholar 

  2. Zacharowski K, Zacharowski PA, Reingruber S, Petzelbauer P (2006) Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction. J Mol Med 84(6): 469–477

    Article  PubMed  Google Scholar 

  3. Henning R, Zacharowski K, Petzelbauer P (2006) FX06 (fibrin-derived peptide Bb15–42) – a potential candidate for myocardial reperfusion therapy. Drugs Future 31(9): 811–818

    Article  Google Scholar 

  4. Zacharowski K, Zacharowski PA, Friedl P et al. (2007) The effects of the fibrin-derived peptide Bβ15–42 in acute and chronic rodent models of myocardial ischemia-reperfusion. Shock (in press)

  5. Springer TA (1995) Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57: 827–872

    Article  PubMed  Google Scholar 

  6. Albelda SM, Smith CW, Ward PA (1994) Adhesion molecules and inflammatory injury. FASEB J 8(8): 504–512

    PubMed  Google Scholar 

  7. Wiman B, Collen D (1978) Molecular mechanism of physiological fibrinolysis. Nature 272(5653): 549–550

    Article  PubMed  Google Scholar 

  8. Gaffney PJ (2001) Fibrin degradation products. A review of structures found in vitro and in vivo. Ann N Y Acad Sci 936: 594–610

    PubMed  Google Scholar 

  9. Altieri DC, Agbanyo FR, Plescia J et al. (1990) A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). J Biol Chem 265(21): 12119–12122

    PubMed  Google Scholar 

  10. Altieri DC, Plescia J, Plow EF (1993) The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion. J Biol Chem 268(3): 1847–1853

    PubMed  Google Scholar 

  11. Altieri DC, Duperray A, Plescia J et al. (1995) Structural recognition of a novel fibrinogen gamma chain sequence (117–133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction. J Biol Chem 270(2): 696–699

    Article  PubMed  Google Scholar 

  12. Farrell DH, Thiagarajan P, Chung DW, Davie EW (1992) Role of fibrinogen alpha and gamma chain sites in platelet aggregation. Proc Natl Acad Sci U S A 89(22): 10729–10732

    Article  PubMed  Google Scholar 

  13. Suehiro K, Gailit J, Plow EF (1997) Fibrinogen is a ligand for integrin alpha5beta1 on endothelial cells. J Biol Chem 21; 272(8): 5360–5366

    Google Scholar 

  14. Yokoyama K, Zhang XP, Medved L, Takada Y (1999) Specific binding of integrin alpha v beta 3 to the fibrinogen gamma and alpha E chain C-terminal domains. Biochemistry 4;38(18): 5872–5877

    Google Scholar 

  15. Loike JD, Sodeik B, Cao L et al. (1991) CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen. Proc Natl Acad Sci U S A 88: 1044–1048

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Keine Angaben.

Author information

Authors and Affiliations

  1. Dept. of Anaesthesia, BHI, Bristol Royal Infirmary, BS2 8HW, Bristol, United Kingdom

    K. Zacharowski

Authors
  1. K. Zacharowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Zacharowski.

Additional information

Gewidmet Herrn Prof. Dr. med. R. Zander zum 65. Geburtstag und zu seiner Pensionierung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zacharowski, K. Neue Überlegungen zu Entzündung und Gerinnung. Anaesthesist 56, 482–484 (2007). https://doi.org/10.1007/s00101-007-1163-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00101-007-1163-3

Schlüsselwörter

Keywords

Search

Navigation