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Myofibroblastic Sarcoma of the Base of Tongue

Case Report and Review of the Literature

Myofibroblastisches Sarkom des Zungengrundes. Fallbericht und Literaturübersicht

  • Case Study
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Background:

Mesenchymal malignancies with myofibroblastic differentiation exhibit a spectrum from low-grade myofibroblastic sarcoma mimicking fibromatosis to pleomorphic high-grade sarcoma. Low-grade myofibroblastic sarcoma shows a wide anatomic distribution with a predilection for the head-and-neck region; however, intermediate- and high-grade myofibroblastic sarcomas in this localization are exceptional.

Case Report:

A 56-year-old woman with intermediate-grade myofibroblastic sarcoma of the base of tongue is presented. She was treated with surgical excision, but computed tomography proved local residual tumor. Reexcision and chemotherapy were refused by the patient. Irradiation was given to a total dose of 66 Gy.

Result:

50 months after completion of radiotherapy, the patient is in good health without any evidence of disease. According to the review of the literature, base of tongue as the primary site of myofibroblastic sarcoma has not been published so far.

Conclusion:

Similarly to the low-grade form, intermediate- and high-grade myofibroblastic sarcomas may also occur in the head-and-neck region. In case of incomplete excision, radiotherapy may be an effective treatment.

Hintergrund:

Mesenchymale maligne Tumoren mit myofibroblastischer Differenzierung beinhalten ein Spektrum von niedrigmalignen myofibroblastischen Sarkomen, die einer Fibromatose ähneln, bis hin zu hochmalignen pleomorphen Sarkomen. Niedrigmaligne myofibroblastische Sarkome treten in allen Körperregionen auf, bevorzugt im Kopf-Hals-Bereich. Intermediär- und hochmaligne myofibroblastische Sarkome sind im Kopf-Hals-Bereich selten zu finden.

Fallbericht:

Vorgestellt wird 56-jährige Patientin mit intermediärmalignem myofibroblastischem Sarkom des Zungengrundes. Nach Exzision fand sich in der CT-Untersuchung ein lokaler Residualtumor. Reexzision und adjuvante Chemotherapie wurden von der Patientin abgelehnt. Sie erhielt eine Radiatio mit einer Gesamtdosis von 66 Gy.

Ergebnis:

50 Monate nach Beendigung der Strahlentherapie ist die Patientin in gutem Allgemeinzustand und tumorfrei. Die Durchsicht der aktuellen Fachliteratur ergab, dass bisher noch kein primäres myofibroblastisches Sarkoms im Bereich des Zungengrundes beschrieben wurde.

Schlussfolgerung:

Intermediär- und hochmaligne myofibroblastische Sarkome können ebenso wie die niedrigmalignen myofibroblastischen Sarkome im Kopf-Hals-Bereich auftreten. Eine postoperative Strahlentherapie nach inkompletter Resektion stellt eine effektive Behandlungsmethode dar.

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Authors and Affiliations

  1. Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary

    Zoltán Takácsi-Nagy MD, PhD & János Fodor

  2. Department of Otorhinolaryngology, Szent Imre Hospital, Budapest, Hungary

    Györgyi Muraközy

  3. Department of Pathology, Szent Imre Hospital, Budapest, Hungary

    Péter Pogány

  4. Department of Pathology, National Institute of Oncology, Budapest, Hungary

    Zsolt Orosz

  5. Department of Radiotherapy, National Institute of Oncology, Ráth György u. 7–9, 1122, Budapest, Hungary

    Zoltán Takácsi-Nagy MD, PhD

Authors
  1. Zoltán Takácsi-Nagy MD, PhD
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  2. Györgyi Muraközy
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  3. Péter Pogány
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  4. János Fodor
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  5. Zsolt Orosz
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Corresponding author

Correspondence to Zoltán Takácsi-Nagy MD, PhD.

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Takácsi-Nagy, Z., Muraközy, G., Pogány, P. et al. Myofibroblastic Sarcoma of the Base of Tongue. Strahlenther Onkol 185, 198–201 (2009). https://doi.org/10.1007/s00066-009-1925-8

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  • DOI: https://doi.org/10.1007/s00066-009-1925-8

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