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Elevated Intraocular Pressure Moderated Brain Morphometry in High-tension Glaucoma: a Structural MRI Study

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Abstract

High-tension glaucoma (HTG) is one of the most common forms of primary open angle glaucoma. The purpose of this study was to assess in HTG brain, whether the elevated intraocular pressure (IOP) had an effect on the brain morphological alterations via structural MRI. We acquired T1WI structural MRI images from 56 subjects including 36 HTG patients and 20 healthy controls. We tested whether the brain morphometry was associated with the mean IOP in HTG patients. Moreover, we conducted moderation analysis to assess the interactions between subject type (HTG - healthy controls) and IOP. In HTG group, cortical thickness was negatively correlated with the mean IOP in the left rostral middle frontal gyrus, left pars triangularis, right precentral gyrus, left postcentral gyrus, left superior temporal gyrus (p < 0.05, FDR corrected). Four of the five regions negatively correlated with mean IOP showed reduced cortical thickness in HTG group compared with healthy controls, which were the left rostral middle frontal gyrus, left pars triangularis, left postcentral gyrus and left superior temporal gyrus (p < 0.05, FDR corrected). IOP moderated the interaction between subject type and cortical thickness of the left rostral middle frontal gyrus (p = 0.0017), left pars triangularis (p = 0.0011), left postcentral gyrus (p = 0.0040) and left superior temporal gyrus (p = 0.0066). Elevated IOP may result brain morphometry alterations such as cortical thinning. The relationship between IOP and brain morphometry underlines the importance of the IOP regulation for HTG patients.

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Funding

This study was supported by the Taishan Scholars Program of Shandong Province (Grant number: TS201712065), Academic Promotion Program of Shandong First Medical University (Grant number: 2019QL009), Natural Science Foundation of Shandong Province (Grant number: ZR2023QH109), and Science and Technology funding from Jinan (Grant number: 2020GXRC018).

Author information

Authors and Affiliations

  1. Center of Radiation Therapy, Taian Tumor Hospital, Taian, China

    Liang Jing

  2. Department of Ophthalmology, Taian City Central Hospital, Taian, China

    Tingqin Yan

  3. Department of Radiology, Taian City Central Hospital, Taian, China

    Jian Zhou & Yuanzhong Xie

  4. Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, China

    Jianfeng Qiu & Weizhao Lu

  5. Department of Ophthalmology, The Second Affiliated hospital of Shandong First Medical University, Taian, China

    Yi Wang

  6. Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China

    Weizhao Lu

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  1. Liang Jing
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  2. Tingqin Yan
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  3. Jian Zhou
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  4. Yuanzhong Xie
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  7. Weizhao Lu
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Corresponding authors

Correspondence to Yi Wang or Weizhao Lu.

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Conflict of interest

L. Jing, T. Yan, J. Zhou, Y. Xie, J. Qiu, Y. Wang and W. Lu declare that they have no competing interests.

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Data Accessibility statement

The data of this study are available upon reasonable request from corresponding authors.

Supplementary Information

62_2023_1351_MOESM1_ESM.docx

Supplementary Tables 1–4 Results of the moderation analysis investigating IOP as a moderator of the association between subject type (HTG-HC) and cortical thickness of the left rostral middle frontal gyrus, left pars triangularis, left postcentral gyrus, left superior temporal gyrus.

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Jing, L., Yan, T., Zhou, J. et al. Elevated Intraocular Pressure Moderated Brain Morphometry in High-tension Glaucoma: a Structural MRI Study. Clin Neuroradiol 34, 173–179 (2024). https://doi.org/10.1007/s00062-023-01351-6

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  • DOI: https://doi.org/10.1007/s00062-023-01351-6

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