Cardiac disease-induced trauma and stress-related disorders

Objective This review aims to present an updated overview of cardiac disease-induced trauma and stress-related disorders such as acute stress disorder (ASD), adjustment disorder (AjD), and posttraumatic stress disorder (PTSD). First, the prevalence of these disorders, their diagnostic criteria, and their differences from other trauma-related disorders are described. Special challenges in diagnosis and treatment are identified, with various screening tools being evaluated for symptom assessment. Additionally, the risk factors studied so far for the development of symptoms of cardiac-induced posttraumatic stress disorder and the bidirectional relationship between posttraumatic stress disorder and cardiovascular diseases are summarized. Various therapeutic interventions, including pharmacological approaches, are also discussed. Finally, various areas for future research are outlined. Background Experiencing a cardiovascular disease, particularly a life-threatening cardiac event, can potentially lead to stress-related disorders such as ASD, AjD, and cardiac disease-induced PTSD (CDI-PTSD). If left untreated, these disorders are associated with a worsening cardiac prognosis and higher mortality rates. Approaching treatment through a trauma-focused lens may be beneficial for managing CDI-PTSD and stress-related disorders. Conclusion Future research should explore treatment options for both the patients and the caregivers as well as investigate the long-term effects of trauma-focused interventions on physical and mental health outcomes.


Background
Cardiovascular diseases (CVD) and acute cardiac events such as acute coronary syndrome (ACS) continue to be the leading cause of morbidity and mortality worldwide [1].Although hospitalization rates and mortality from CVD have declined in recent years due to improvements in medical care and the management of risk factors, demographic shifts have resulted in a rise in the incidence of CVD, presenting substantial medical and economic challenges for the healthcare system [2].
A sudden acute cardiac event carries an imminent risk of death and can evoke feelings of anxiety, loss of control, and help-lessness, which can potentially be traumatic [3].Patients suffering from these symptoms may qualify for a formal diagnosis of acute stress disorder (ASD) occurring within 1 month of the cardiac event.Generally, an episode of ASD fades quickly, most often without need for treatment.However, in a substantial number of cases, adjustment disorder (AjD) and/or cardiac diseaseinduced (CDI-) posttraumatic stress disorder (CDI-PTSD) may occur.
Cardiac disease induced-induced PTSD is defined by the presence of multiple clusters of psychological, behavioral, and physiological symptoms, including intrusive thoughts (intrusions), avoidance, negative changes in cognition and mood, as Table 1 Prevalence rates of acute stress disorder (ASD), adjustment disorder (AjD), and cardiac-induced posttraumatic stress disorder (CDI-PTSD )
Pivotal stress periods identified (e.g., after discharge, after implantation of device) [14] CDI-PTSD 4-44% [15] 12% average across CVD [7] Prevalent in 45-48% of partners of CA patients [10] Prevalent in 12-31% of children with cardiac surgery [16] ACS acute coronary syndrome, CA cardiac arrest, CVD cardiovascular disease, ED emergency department well as increased arousal and stress reactivity [4].Trauma-related disorders caused by cardiac diseases not only significantly impair quality of life [5] but are also associated with an increased risk of another cardiac event and increased mortality in the first 3 years following the initial event [6].

Prevalence rates
A significant proportion of CVD patients have stress-related disorders. .Table 1 gives an overview of prevalence rates for the three disorders (ASD, AjD, and PTSD).Notably, prevalence rates vary widely across different CVD events [7].

Diagnostic criteria
.

Differences from other traumarelated disorders
Post-traumatic stress disorder (PTSD) induced by a medical event can exhibit several pertinent differences from other trauma-related disorders [17]: 1. Source of threat: Cardiac traumarelated disorders stem from internal threats originating from within one's own body, such as heart-related events, unlike traditional trauma that typically involves external causes like accidents, assaults, or disasters.

Challenges in diagnosis and treatment
Distinguishing between physical symptoms of cardiac trauma-related disorders and symptoms of actual heart disease can be challenging for both the patients and the clinicians, potentially leading to prolonged anxiety and difficulty in initiating appropriate treatment.Tailored interventions that address the unique challenges of cardiac trauma-related disorders may be necessary for effective management.These differences highlight the distinct nature of trauma-related disorders stemming from cardiac events compared to those arising from traditional traumatic experiences, necessitating specialized approaches in diagnosis and treatment [18].

Screening tools
ICD-11 and the "Adjustment Disorder-New Module" The diagnosis of AjD typically depends on the clinical judgment of a professional, as there is no established gold standard for standardized assessment.The new ICD-11 diagnostic criteria for AjD support a unifaceted approach with core symptoms and additional features, resulting in a clearer diagnostic concept [19].Central symptoms include preoccupation with the stressor and an inability to adapt.sive thoughts about future cardiac events.Presently, there is no dedicated diagnostic tool designed for evaluating CDI-induced PTSD symptoms.International and scientific clinical guidelines advocate for the screening of all cardiac patients for psychological distress following such an event [22].Early recognition and interventioncansignificantlyimproveoutcomes for these patients [22].The Primary Care PTSD Checklist (PC-PTSD) can be used to screen for PTSD in cardiac patients [23].The PC-PTSD-5 is effectual in identifying potential PTSD symptoms on an individual basis.The questions about the individual symptoms of PTSD should refer to the cardiac event as the traumatic experience.Patients who test positive on the screening require further assessment, ideally conducted through structured interviews.

Risk factors for the development of CDI-PTSD
Numerous studies indicate that risk factors for CDI-PTSD following a cardiac event encompass various domains.These include sociodemographic factors (such as female gender, younger age, and potentially ethnic minority status and low education), psychological characteristics (including prior psychological issues, high intrusion symptoms, and severity of ASD and depression symptoms), and aspects related to the cardiac event itself (such as perception of life threat, history of referral to a psychologist, and the context of care during the event; [24,25]).Of particular importance is an individual's perception of illness following a cardiac event, which consistently influences the development of CDI-PTSD symptoms [26].Specifically, intense pain, fear, and helplessness in response to the ACS significantly heighten the likelihood of PTSD development [27].Contradictory results have been reported with the use of benzodiazepines, as sedation in the initial phase of resuscitation reduced the risk of developing PTSD [28].However, patients with an ACS and benzodiazepines had an increased risk of PTSD [29].Additional risk factors for the development of these symptoms include environmental and treatment-related factors (e.g., chaotic hospital admissions, treatment complications, staff statements; [29]), personality traits (Type D, neuroticism, hostility, alexithymia; [11]), and a patient's biopsychosocial history (stressful life events, prior heart disease, other somatic conditions; [30]).Cardiac patients treated during emergency department overcrowding, hallway care, and perceived inadequate clinician-patient communication also appear to be at greater risk for subsequent PTSD [31].Interestingly, objective indicators of cardiac injury, such as troponin T levels in ACS, show little correlation with subsequent PTSD symptoms [27].Conversely, social support and resilience factors (such as internal control beliefs, humor, patience, and repressive coping strategies immediately after the traumatic event) have been shown to have a protective effect against the development of CDI-PTSD symptoms [24].

The bidirectional association between PTSD and CVD
The bidirectional association between PTSD and CDI-PTSD has long been linked to an increased risk of CVD, although the precise reciprocal relationship between PTSD and CVD remains not fully understood [32].Several physiological mechanisms have been investigated to elucidate the link between PTSD and CVD, including autonomic dysfunction, disruptions in neuroendocrine regulation, and inflammatory processes (for details, refer to [33]).Various neurobiological underpinnings may be involved, consistent with the conceptualization of PTSD as a disorder characterized by altered formation and/or extinction of emotional memories, along with dysregulated responses to threat and stress [34].These encompass alterations in the functioning and connectivity of specific brain regions crucial for emotional processing and cognition, notably the amygdala, insula, dorsal anterior cingulate, and ventromedial prefrontal cortex [34].

Therapeutic interventions
Preventing cardiac-induced stress-related disorders involves addressing both the physical and psychological aspects of cardiac events.Since not all cardiac events can be prevented, it is important to note that several strategies can help reduce the risk and mitigate the impact of traumatic experiences related to these events.Given that the personal experience of stress and discomfort is more important than the severity of the cardiac condition [7], establishing a sense of safety and control is essential.
An immediate one-time trauma-specific counseling shows no beneficial longterm effect on preventing posttraumatic stress compared with one session of gen-eral stress counseling [35,36].However, trauma-specific counseling was more effective in patients who perceived an increased level of social support [37].After a cardiac event, there are several starting points for preventive interventions based on the aforementioned risk factors.Providing patients and their families with information and education about cardiac conditions, treatment options, and coping strategies could help reduce anxiety, fear, and distress.A multidisciplinary approach has been emphasized to support ICD patients with shock experience and provide detailed and practice-friendly psychoeducation [38].Furthermore, web-based cognitive behavioral therapy (CBT) has been recommended as a low-threshold alternative to in-person treatments for centers lacking comprehensive cardiac psychology services.
This goes in line with therapeutic options for AjD.Interventions usually aim at three factors: (a) elimination or mitigation of stress (e.g., treatment of underlying CVD); (b) improvement of coping and adaptation (e.g., taking up activities); and (c) symptom reduction and behavioral change (e.g., CBT for anxiety/depression; [39]).As AjD is by definition transient, the authors propose a stepped approach with level 1 watchful waiting, which could be accomplished during cardiac rehabilitation.Level 2 consists of low-intensity psychological interventions such as web-based programs.For those patients who do not benefit sufficiently, level 3 recommends individual psycho-and/or pharmacotherapy.Level 4 includes inpatient treatment for people with severe AjD with, for instance, suicidal tendencies [39].A recent review and meta-analysis reported web-based interventions for AjD areas to be effective [40].One example is the Internet-based modular program Brief Adjustment Disorder Intervention (BADI) for ICD-11-AjD [41].The BADI is a CBT-based program and consists of four modules: relaxation, time management, mindfulness, and strengthening relationships.It showed promising effects on AjD when used at least once in 30 days [42].Therapeutic support did not enhance its effectiveness [43].Participation in cardiac rehabilitation following a cardiac event can help individuals recover physically and emotionally.These programs typically encompass supervised exercise training, educational sessions promoting heart-healthy lifestyle modifications, and counseling or support groups to address psychological concerns.However, individuals with PTSD or AjD exhibit reduced participation in physical activity and tend to avoid their physical limits [21,44].As the occurrence of somatic symptoms such as chest tightness or heartbeat symptoms can increase post-traumatic stress [45], this could culminate in a self-perpetuating cycle of avoidance with mutually reinforcing factors.Exercise, however, has a beneficial effect on PTSD, whether used alone or as a complement to conventional therapy [46].
Despite the undeniable indication for therapeutic intervention, a study reported only 30-40% of patients with diagnosed CDI-PTSD received some form of treatment, whether medication or counseling [47].Trauma-focused psychotherapy is more beneficial than non-trauma-focused therapies in reducing PTSD severity [48].Meta-analyses have demonstrated encouraging findings regarding the efficacy and long-term impact of exposure-based therapies such as prolonged exposure (PE), trauma-focused CBT, cognitive therapy (CT), and eye movement desensitization and reprocessing (EMDR; [49]) as well as narrative exposure therapy (NET; [50]).Imaginal exposure therapy (IET) proved safe, as evidenced by the absence of significant changes in blood pressure and heart rate during exposures [51].Promising approaches extend beyond traditional psychotherapeutic interventions.Innovative therapies such as biofeedback may serve as a variation of exposure therapy [52].

Pharmacotherapy
In addition to psychotherapy, psychotropic drugs are another option for treatment of severe PTSD.Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are the drugs of choice [53].Of the SSRI group, sertraline and citalopram seem safe for patients with CVD [54].Tricyclics should be avoided in patients with CVD [15].Furthermore, clinicians should monitor possible cardiometabolic side effects (e.g., weight Herz 4 • 2024 257 gain) and discuss the risks and benefits of the medication with patients before and throughout the treatment [53].Benzodiazepines exhibit a short-term anxiolytic effect, yet they increase the risk of developing PTSD symptoms after an ACS, making it advisable to use them with caution [29].An important contraindication arises concerning patients with heart failure, as antidepressants have been associated with an increased risk of all-cause mortality [55].Antidepressants, i.e., SSRIs, should therefore be avoided in favor of psychotherapy [56].There is only limited research on pharmacotherapy for AjD, but studies suggest caution against the use of benzodiazepines [57].

Future research
Future research should aim to better identify early signs of CDI-induced distress with screening for ASD, especially in patients with a history of mental illness, as they seem most vulnerable to additional stress [58].Clinician-patient communication is a critical factor that can influence the development of PTSD symptoms [59].As the perception of a hectic hospital environment and crowded emergency department are associated with an increased risk for ASD and PTSD and can lead to a higher re-admission rate [60,61], interventions should go beyond individual care and address structural factors, too.Future research on effective interventions for ASD should aim to help patients with cardiac disease mitigate their distress and perceived threat while concurrently preventing the emergence of long-term cardiac trauma and stress-related disorders such as AjD and PTSD.Not all patients benefit from the same intervention [37].
Further research is needed to identify specific risk factors, enabling more personalized interventions that effectively target the most vulnerable patients and those who benefit the most.A promising differentiation has been offered in a recent study of ACS patients that identified three clusters associated with posttraumatic stress and depression [62]: (a) low-risk cluster with the highest resilience, task-oriented coping, positive affect, and social support; (b) a lonely cluster with the lowest social support and resilience; and (c) avoidant cluster with the lowest task-oriented coping and positive affect.Future research is needed to assess whether addressing these factors may yield protective benefits.Research on early intervention after a traumatically experienced medical event to prevent PTSD is promising, albeit preliminary and limited [63], but is even more sparse regarding AjD.One barrier is the unclear defined criteria and the lack of assessment methods for AjD [64].The ICD-11 introduced a major change in the definition of AjD with two core symptoms: preoccupation and failure to adapt [65].Increasing evidence supports the concept [66] and the assessment tool (ADNM; [19]).With the establishment of standardized criteria and assessment tools, future studies can more reliably assess the efficacy of preventive and early intervention programs for AjD.For this article no studies with human participants or animals were performed by any of the authors.All studies mentioned were in accordance with the ethical standards indicated in each case.

Conclusion
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Zusammenfassung
The development of targeted interventions for the unique challenges posed by traumarelated disorders in the context of cardiac events, including adjustment disorder and cardiac disease-induced posttraumatic stress disorder, is crucial.These interventions should aim to address the specific symptomatology, risk factors, and barriers to treatment engagement associated with cardiac traumarelated disorders, thus improving patient outcomes and quality of life.The integration of psychological support into standard cardiac care pathways, such as cardiac rehabilitation programs, may help ensure that patients receive timely and appropriate interventions to address their psychological needs alongside their physical recovery.Corresponding address PD Dr. phil.Mary Princip Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich Haldenbachstrasse 16/18, 8091 Zurich, Switzerland mary.princip@usz.chFunding.Open access funding provided by University of Zurich Declarations Conflict of interest.M. Princip, K. Ledermann, R. Altwegg and R. von Känel declare that they have no competing interests.

Table 2
[4]vides an overview of the symptoms for ASD, AjD, and PTSD based on the tenth revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10;[4]).

Table 2
Symptoms of acute stress disorder (ASD), adjustment disorder (AjD), and posttraumatic stress disorder based on ICD-10