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Kundi et al. [1] reported that the ratio of monocyte to high-density lipoprotein cholesterol (MHR) levels was significantly higher in patients with stable coronary artery disease (SCAD) and a high SYNTAX score. MHR is a simple and widely available marker and they recommended the use of MHR as a prognostic marker for SCAD patients. We thank the authors for their contribution.
It has been demonstrated that inflammation and oxidative stress play a significant role in the formation and progression of atherosclerosis [2]. Circulating monocytes interact with platelets and endothelial cells thereby leading to aggravation of inflammatory and prothrombotic pathways [3]. High-density lipoprotein (HDL) inhibits the migration of macrophages, deactivates the pro-inflammatory and pro-oxidant effects of monocytes, and defuses oxidized LDL molecules, as well as promoting the efflux of cholesterol from these cells [4]. Consequently, MHR was defined as an easily available inflammatory and oxidative stress marker.
MHR has been reported as a new prognostic marker in cardiovascular diseases [5, 6]. Canbolat et al. [7] reported that a higher MHR, which indicates an enhanced inflammation and oxidative stress, was significantly and independently associated with the presence of slow coronary flow. In a recent study by Ucar, both MHR and uric acid (UA) emerged as significant independent predictors of bare metal stent restenosis [8].
There are many biomarkers of inflammation, but it is difficult to measure oxidative stress in vivo. Easily available and well-known markers of oxidative stress include UA and gamma-glutamyl transferase (GGT) [9, 10]. In this well-presented article by Kundi and colleagues, MHR was significantly higher in patients in the high SYNTAX score group compared with the low SYNTAX score group. Additionally C‑reactive protein levels were significantly higher in the high SYNTAX score group. On the other hand, the serum UA and GGT levels of the study patients were not reported. It may be beneficial to know the UA and GGT values in order to assess the relationship between oxidative stress and SYNTAX score in patients with SCAD.
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S. Soylemez declares that he has no competing interests.
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Soylemez, S. Oxidative stress and Syntax score. Herz 42, 793 (2017). https://doi.org/10.1007/s00059-016-4516-3
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DOI: https://doi.org/10.1007/s00059-016-4516-3