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DABCO-promoted one-pot synthesis of heteroaryl-substituted benzenes and their biological evaluation

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Abstract

A simple and efficient one-pot synthesis of heteroaryl-substituted benzenes has been developed via cyclocondensation of vinylmalononitriles and ethylvinylcyanoacetates with heteroarylnitroolefines using diazabicyclo[2,2,2]octane as catalyst. The titled compounds were evaluated for their antitubercular, antibacterial and antifungal activities at various concentrations.

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Authors and Affiliations

  1. School of Studies in Chemistry & Biochemistry, Vikram University, Ujjain, 456010, Madhya Pradesh, India

    G. Neelaiah Babu & Shubha Jain

  2. Department of Chemistry, College of Natural and Computational Sciences, Haramaya University, Dire Dawa, Ethiopia

    G. Neelaiah Babu & Haile Micheal Ayalew

Authors
  1. G. Neelaiah Babu
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  2. Haile Micheal Ayalew
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  3. Shubha Jain
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Correspondence to G. Neelaiah Babu.

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Babu, G.N., Ayalew, H.M. & Jain, S. DABCO-promoted one-pot synthesis of heteroaryl-substituted benzenes and their biological evaluation. Med Chem Res 23, 2608–2614 (2014). https://doi.org/10.1007/s00044-013-0857-0

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  • DOI: https://doi.org/10.1007/s00044-013-0857-0

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