Abstract
In the realm of biochemical research, chalcones have been efficiently explored as antimicrobial agents. The present study focuses on the synthesis of pyrimidine chalcones, i.e. (E)-1-(6′-hydroxy-1′,3′-dimethyl-1′,2′,3′,4′-tetrahydro-2′,4′-dioxopyrimidin-5′-yl)-3-[-p-{(1″-aryl-1H-1″,2″,3″-triazol-4″-yl) methoxy}phenyl]-prop-2-ene-1-ones (7a–7i) by the reaction of 4-triazolomethoxybenzaldehyde, i.e. 4-{(1-aryl-1H-1,2,3-triazol-4-yl)methoxy}benzaldehyde (4a–4i) and 5-acetyl-1,3-dimethylbarbituric acid in (6) 50–80 % yields. The structures of these compounds were established on the basis of their FT-IR, 1H NMR, 13C NMR and mass spectral analysis. Compounds 7b–7i were screened for their in vitro antibacterial activity against Rhodococcus rhodochrous MTCC 265, a gram +ve bacteria and Escherichia coli, a gram −ve bacteria by the agar disc diffusion method.
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Acknowledgments
The authors would like to thank Council of Scientific and Industrial Research, New Delhi and Defence Research and Development Organisation for the financial support. NI acknowledges Department of Biotechnology for the award of research fellowship.
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Kumar, R., Arora, J., Prasad, A.K. et al. Synthesis and antimicrobial activity of pyrimidine chalcones. Med Chem Res 22, 5624–5631 (2013). https://doi.org/10.1007/s00044-013-0555-y
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DOI: https://doi.org/10.1007/s00044-013-0555-y