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Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents

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Abstract

A novel series of 4,6-diaryl-2-aminopyrimidines 8ao has been synthesized and evaluated for in vitro antiplasmodial activity against Plasmodium falciparum. Out of the 15 compounds synthesized and tested, 6 compounds have shown IC50 values in the range of 1.61–9.53 μg/mL. These compounds are several times more potent than chloroquine and quinine, the two standard drugs used for the purpose of comparison.

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Acknowledgments

We thank All India Council for Technical Education (AICTE), New Delhi, India, for financial support in the form of Research Promotion Scheme [File No. 8023/RID/RPS/46/2004e05] to RG and National Doctoral Fellowship to RST [File No. 1–10/RID/NDF/PG/36/2009–2010].

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Correspondence to Rajani Giridhar.

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Giridhar, R., Tamboli, R.S., Prajapati, D.G. et al. Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents. Med Chem Res 22, 3309–3315 (2013). https://doi.org/10.1007/s00044-012-0328-z

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  • DOI: https://doi.org/10.1007/s00044-012-0328-z

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