Abstract
The sulfonoquinovosyldiacylglyceride (SQDG) isolated from the leaves of Azadirachta indica showed significant anti-leukemic activity in human leukemic cell lines U937 and K562 with IC50 of 9 μg/ml. SQDG treated leukemic cells showed chromatin condensation, apoptotic body formation, and increased caspase 3 production indicating apoptosis. Cell cycle study revealed that the treated leukemic cells accumulated in the sub-G1 phase; the cell cycle was halted in this phase and the DNA content decreased in other phases.
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The authors acknowledge the Council of Scientific and Industrial research for financial support and Dr. B. Achari for constant encouragement.
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Yogesh P, B., Bhattacharya, S., Das, T. et al. Anti-leukemic activity of sulfonoquinovosyldiacylglyceride (SQDG): a constituent of Azadirachta indica leaves. Med Chem Res 22, 22–27 (2013). https://doi.org/10.1007/s00044-012-0001-6
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DOI: https://doi.org/10.1007/s00044-012-0001-6