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Epidermal resident γδ T cell development and function in skin

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Abstract

Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.

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Acknowledgements

This study is supported by the Henry Ford Immunology Program Grants (T71016, QS Mi; T71017, L Zhou).

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Authors and Affiliations

  1. Experimental Research Center, Dermatology Hospital of Southern Medical University, and Guangdong Provincial Dermatology Hospital, Guangzhou, China

    Yingping Xu

  2. Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health System, Detroit, MI, USA

    Yingping Xu, Peter Dimitrion, Steven Cvetkovski, Li Zhou & Qing-Sheng Mi

  3. Immunology Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA

    Peter Dimitrion, Steven Cvetkovski, Li Zhou & Qing-Sheng Mi

  4. Department of Biochemistry, Microbiology and Immunology, Wayne State University School Medicine University, Detroit, MI, USA

    Peter Dimitrion, Steven Cvetkovski, Li Zhou & Qing-Sheng Mi

  5. Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA

    Li Zhou & Qing-Sheng Mi

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  1. Yingping Xu
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  2. Peter Dimitrion
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  4. Li Zhou
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  5. Qing-Sheng Mi
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Correspondence to Li Zhou or Qing-Sheng Mi.

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Xu, Y., Dimitrion, P., Cvetkovski, S. et al. Epidermal resident γδ T cell development and function in skin. Cell. Mol. Life Sci. 78, 573–580 (2021). https://doi.org/10.1007/s00018-020-03613-9

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