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Epigenetic control of embryo–uterine crosstalk at peri-implantation

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Abstract

Embryo implantation is one of the pivotal steps during mammalian pregnancy, since the quality of embryo implantation determines the outcome of ongoing pregnancy and fetal development. A large number of factors, including transcription factors, signalling transduction components, and lipids, have been shown to be indispensable for embryo implantation. Increasing evidence also suggests the important roles of epigenetic factors in this critical event. This review focuses on recent findings about the involvement of epigenetic regulators during embryo implantation.

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Acknowledgements

This review article was supported in parts by National Key R&D program of China (2017YFC1001402 to H.W.), and the National Natural Science Foundation (81601285 to S.K., 81830045 and 81490744 to H. W. and 31600945 to J.L.) and Fundamental Research Funds for the Central Universities (20720180039 to S.K., 20720180041 to J.L.).

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  1. Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, Fujian, People’s Republic of China

    Shuangbo Kong, Lin Huang, Yang Sun, Haibin Wang & Jinhua Lu

  2. Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, People’s Republic of China

    Shuangbo Kong, Chan Zhou, Haili Bao, Zhangli Ni, Mengying Liu, Bo He, Lin Huang, Yang Sun, Haibin Wang & Jinhua Lu

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Kong, S., Zhou, C., Bao, H. et al. Epigenetic control of embryo–uterine crosstalk at peri-implantation. Cell. Mol. Life Sci. 76, 4813–4828 (2019). https://doi.org/10.1007/s00018-019-03245-8

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