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Regulated cell death and adaptive stress responses

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Abstract

Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.

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Acknowledgments

The authors are supported by the Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR)—Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Institut National du Cancer (INCa); Fondation Bettencourt-Schueller; Fondation de France; Fondation pour la Recherche Médicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); the Swiss Bridge Foundation, ISREC and the Paris Alliance of Cancer Research Institutes (PACRI).

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Authors and Affiliations

  1. Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006, Paris, France

    Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Oliver Kepp & Guido Kroemer

  2. U1138, INSERM, 75006, Paris, France

    Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Oliver Kepp & Guido Kroemer

  3. Sorbonne Paris Cité, Université Paris Descartes/Paris V, 75006, Paris, France

    Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Oliver Kepp & Guido Kroemer

  4. Université Pierre et Marie Curie/Paris VI, 75006, Paris, France

    Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Oliver Kepp & Guido Kroemer

  5. Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France

    Lorenzo Galluzzi & José Manuel Bravo-San Pedro

  6. Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805, Villejuif, France

    Oliver Kepp & Guido Kroemer

  7. Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015, Paris, France

    Guido Kroemer

  8. Department of Women’s and Children’s Health, Karolinska University Hospital, 17176, Stockholm, Sweden

    Guido Kroemer

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  1. Lorenzo Galluzzi
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  2. José Manuel Bravo-San Pedro
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  3. Oliver Kepp
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  4. Guido Kroemer
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Correspondence to Lorenzo Galluzzi or Guido Kroemer.

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L. Galluzzi and G. Kroemer share senior co-authorship.

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Galluzzi, L., Bravo-San Pedro, J.M., Kepp, O. et al. Regulated cell death and adaptive stress responses. Cell. Mol. Life Sci. 73, 2405–2410 (2016). https://doi.org/10.1007/s00018-016-2209-y

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  • DOI: https://doi.org/10.1007/s00018-016-2209-y

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