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Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation

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Abstract

Sodium absorption by the distal part of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the collecting duct, plays a major role in the control of homeostasis by the kidney. In this part of the nephron, sodium transport can either be electroneutral or electrogenic. The study of electrogenic Na+ absorption, which is mediated by the epithelial sodium channel (ENaC), has been the focus of considerable interest because of its implication in sodium, potassium, and acid–base homeostasis. However, recent studies have highlighted the crucial role played by electroneutral NaCl absorption in the regulation of the body content of sodium chloride, which in turn controls extracellular fluid volume and blood pressure. Here, we review the identification and characterization of the NaCl cotransporter (NCC), the molecule accounting for the main part of electroneutral NaCl absorption in the distal nephron, and its regulators. We also discuss recent work describing the identification of a novel “NCC-like” transport system mediated by pendrin and the sodium-driven chloride/bicarbonate exchanger (NDCBE) in the β-intercalated cells of the collecting system.

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Acknowledgments

R. Chambrey, J. Hadchouel, and D. Eladari are funded by Institut National de la Santé et de la Recherche Médicale (INSERM) and N. Picard is funded by Centre National de la Recherche Scientifique (CNRS). This work was also funded by grants from l’Agence Nationale de la Recherche (BLANC-2010-R10164DD to DE, BLANC-2012-R13011KK to RC, and 2012-ISV1-0001-01 to JH), from the Fondation pour la Recherche sur l’Hypertension Arterielle to JH, from the Société de Néphrologie (subvention de recherche 2013 AMGEN) to NP, and the Fondation du rein (Prix Jeune Chercheur 2012) to NP.

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Authors and Affiliations

  1. Department of Physiology, Hopital Européen Georges Pompidou, AP-HP, 56 rue Leblanc, 75015, Paris, France

    Dominique Eladari

  2. Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, 15 rue de l’Ecole de Médecine, 75006, Paris, France

    Dominique Eladari, Régine Chambrey & Juliette Hadchouel

  3. INSERM UMR_S 970, Equipe 12, Paris Cardiovascular Research Center (PARCC), 56 rue Leblanc, 75015, Paris, France

    Dominique Eladari, Régine Chambrey & Juliette Hadchouel

  4. INSERM UMR_S 872, Equipe 3, Centre de recherche des Cordeliers (CRC), 15 rue de l’Ecole de Médecine, 75006, Paris, France

    Nicolas Picard

  5. CNRS, ERL7226, 75006, Paris, France

    Nicolas Picard

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  1. Dominique Eladari
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  2. Régine Chambrey
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  4. Juliette Hadchouel
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Correspondence to Dominique Eladari.

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Eladari, D., Chambrey, R., Picard, N. et al. Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation. Cell. Mol. Life Sci. 71, 2879–2895 (2014). https://doi.org/10.1007/s00018-014-1585-4

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