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Epigenetic methylations and their connections with metabolism

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Abstract

Metabolic pathways play fundamental roles in several processes that regulate cell physiology and adaptation to environmental changes. Altered metabolic pathways predispose to several different pathologies ranging from diabetes to cancer. Specific transcriptional programs tightly regulate the enzymes involved in cell metabolism and dictate cell fate regulating the differentiation into specialized cell types that contribute to metabolic adaptation in higher organisms. For these reasons, it is of extreme importance to identify signaling pathways and transcription factors that positively and negatively regulate metabolism. Genomic organization allows a plethora of different strategies to regulate transcription. Importantly, large evidence suggests that the quality of diet and the caloric regimen can influence the epigenetic state of our genome and that certain metabolic pathways are also epigenetically controlled reveling a tight crosstalk between metabolism and epigenomes. Here we focus our attention on methylation-based epigenetic reactions, on how different metabolic pathways control these activities, and how these can influence metabolism. Altogether, the recent discoveries linking these apparent distant areas reveal that an exciting field of research is emerging.

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Acknowledgments

We thank all members of the Pasini’s laboratory for comments and discussion. The work in the Pasini’s laboratory is supported by AIRC; the Italian Association of Cancer Research and by the Italian Ministry of Health. AP is supported by a fellowship from FIRC; the Italian Foundation for Cancer Research.

Conflict of interest

The authors declare no competing financial interests.

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  1. Department of Experimental Oncology, European Institute of Oncology (IEO), Via Adamello 16, 20139, Milan, Italy

    Fulvio Chiacchiera, Andrea Piunti & Diego Pasini

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  1. Fulvio Chiacchiera
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  2. Andrea Piunti
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  3. Diego Pasini
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Correspondence to Diego Pasini.

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Chiacchiera, F., Piunti, A. & Pasini, D. Epigenetic methylations and their connections with metabolism. Cell. Mol. Life Sci. 70, 1495–1508 (2013). https://doi.org/10.1007/s00018-013-1293-5

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  • DOI: https://doi.org/10.1007/s00018-013-1293-5

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