Abstract
HLA-G plays a particular role during pregnancy in which its expression at the feto–maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00018-010-0620-3
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Deschaseaux, F., Delgado, D., Pistoia, V. et al. HLA-G in organ transplantation: towards clinical applications. Cell. Mol. Life Sci. 68, 397–404 (2011). https://doi.org/10.1007/s00018-010-0581-6
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DOI: https://doi.org/10.1007/s00018-010-0581-6