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Genetic polymorphisms of the DNA repair geneMPG may be associated with susceptibility to rheumatoid arthritis

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. A previous study indicated that a DNA repair system was involved in the development of RA. In this study, we investigated the association of four N-methylpurine-DNA glycosylase (MPG) gene polymorphisms (rs3176364, rs710079, rs2858056, and rs2541632) with susceptibility to RA in 384 Taiwanese individuals (192 RA patients and 192 control subjects). Our data show a statistically significant difference in genotype frequency distributions at rs710079 and rs2858056 SNPs between RA patients and control groups (P = 0.040 and 0.029, respectively). Our data also indicated that individuals with the GG genotype at rs2858056 SNP may have a higher risk of developing RA. In addition, compared with the haplotype frequencies between case and control groups, individuals with the GCGC haplotype appeared to be at a greater risk of RA progression (P = 0.003, OR = 1.75; 95% CI = 1.20–1.55). Our results suggest that rs710079 and rs2858056 polymorphisms and the GCGC haplotype in theMPG gene are associated with the risk of RA progression, and thus may be used as molecular markers of RA if they are confirmed by further research.

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Authors and Affiliations

  1. Genetic Center, Department of Medical Research, Taichung, Taiwan

    S. Y. Chen, L. Wan, Y. C. Huang, J. J. C. Sheu, Y. J. Lin & F. J. Tsai

  2. Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

    S. Y. Chen, L. Wan, Y. C. Huang, J. J. C. Sheu, Y. J. Lin & C. H. Tsai

  3. Department of Health Risk Management, Taichung, Taiwan

    Y. C. Lan

  4. Department of Microbiology, School of Medicine, Taichung, Taiwan

    C. H. Lai

  5. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

    C. W. Lin

  6. Division of Immunology and Rheumatology, Taichung, Taiwan

    C. M. Huang

  7. Center for Neuropsychiatry, Taichung, Taiwan

    S. P. Liu

  8. Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan

    F. J. Tsai

Authors
  1. S. Y. Chen
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  2. L. Wan
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  3. C. M. Huang
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  4. Y. C. Huang
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  5. J. J. C. Sheu
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  6. Y. J. Lin
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  7. S. P. Liu
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  8. Y. C. Lan
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  9. C. H. Lai
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  10. C. W. Lin
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  11. C. H. Tsai
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  12. F. J. Tsai
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Corresponding author

Correspondence to F. J. Tsai.

Additional information

These authors contributed equally to this work.

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Chen, S.Y., Wan, L., Huang, C.M. et al. Genetic polymorphisms of the DNA repair geneMPG may be associated with susceptibility to rheumatoid arthritis. J Appl Genet 51, 519–521 (2010). https://doi.org/10.1007/BF03208883

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  • DOI: https://doi.org/10.1007/BF03208883

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