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Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man

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Summary

Following oral administration of (+)-catechin and 3-O-methyl-(+)-catechin to human volunteers the major urinary metabolites were shown to be the glucuronides of 3′-O-methyl-(+)-catechin and 3,3′-O-dimethyl-(+)-catechin respectively. Isolations from urine and from synthetic products have been carried out by semi-preparative high performance liquid chromatography; definitive elucidations of structures have been carried out by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.

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References

  1. Blum A. L., Berthet P., Doelle W., Goebell H., Kortum K., Pelloni S., Peter P., Poulsen H., Strohmeyer G., Tygstrup N. (1977): Treatment of acute viral hepatitis with (+)-Cyanidanol-3. Lancet2, 1153–1155.

    Article  CAS  PubMed  Google Scholar 

  2. Griffiths L.A. (1964): Studies on flavonoid metabolism: Identification of the metabolites of (+)-catechin in rat urine. Biochem. J.92, 173–179.

    CAS  PubMed  Google Scholar 

  3. Das N.P., Griffiths L.A. (1969): Metabolism of (+)-[14C]-catechin in the rat and guinea pig. Biochem. J.115, 831–836.

    CAS  PubMed  Google Scholar 

  4. Das N.P. (1971): Studies on flavonoid metabolism: Absorption and metabolism of (+)-catechin in man. Biochem. Pharmacol.20, 3435–3445.

    Article  CAS  PubMed  Google Scholar 

  5. Shaw I.C., Griffiths L.A. (1980): Identification of the major biliary metabolite of (+)-catechin in the rat. Xenobiotica10, 905–911.

    Article  CAS  PubMed  Google Scholar 

  6. Hackett A.M., Shaw I.C., Griffiths L.A. (1982): 3′-O-Methyl-(+)-catechin glucuronide and 3′-O-Methyl-(+)-catechin sulphate: New urinary metabolites of (+)-catechin in the rat. Experientia38, 538–539.

    Article  CAS  PubMed  Google Scholar 

  7. Hackett A.M., Griffiths L.A. (1981): The metabolism and excretion of 3-O-Methyl-(+)-catechin in the rat, mouse and marmoset. Drug Metabolism and Disposition9, 54–59.

    CAS  PubMed  Google Scholar 

  8. Albert A., Courbat P. (1981): Personal Communication, Zyma SA.

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Authors and Affiliations

  1. Research and Development Department, Zyma SA, CH-1260, Nyon, Switzerland

    M. Wermeille & E. Turin

  2. Department of Biochemistry, University of Birmingham, Birmingham, UK

    L. A. Griffiths

Authors
  1. M. Wermeille
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  2. E. Turin
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  3. L. A. Griffiths
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Wermeille, M., Turin, E. & Griffiths, L.A. Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man. European Journal of Drug Metabolism and Pharmacokinetics 8, 77–84 (1983). https://doi.org/10.1007/BF03189584

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  • DOI: https://doi.org/10.1007/BF03189584

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