Abstract
Maternal stress during pregnancy produced behavioral alterations in both sexes with regard to sexual behavior, aggressive, maternal, lateralization and depression. In the present paper, sex differences for depression in mice was studied. No sex differences between female and male mice groups were observed either in swimming-induced immobility or in the open-field test (ambulation, rearing and boluses). Prenatal stress produced: 1) an increase of immobility time in female mice for swimming-induced immobility, but not in male mice; 2) an increase of ambulation in female mice for open-field test, but not in male mice; 3) there were no significant differences in rearing and boluses between stress and control groups either for female or male mice. Prenatal stress increases the risk of depression and locomotor activity in adult female mice.
Resumen
El estrés prenatal durante el embarazo produce alteraciones conductuales en ambos sexos referidas a la conducta sexual, agresiva, maternal, de lateralización y depresiva. En el presente trabajo, se estudian las diferencias sexuales para la depresión en ratones. No se encuentran diferencias sexuales entre los grupos de ratones hembra y machos para el test de inmovilidad inducida por natación ni para el test de campo abierto (deambulaciones, incorporaciones y bolos). El estrés prenatal produce: 1) incremento en el tiempo de inmovilidad en ratones hembra para el test de inmovilidad inducida por natación, pero no en ratones macho; 2) incremento de deambulaciones en ratones hembra para el test de campo abierto, pero no en ratones macho y 3) no existen diferencias en las incorporaciones y bolos entre los grupos de estrés y control, tanto para hembras como para machos. El estrés prenatal aumenta el riesgo de depresión y la actividad locomotora en ratones hembra adultos.
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Alonso, S.J., Damas, C. & Navarro, E. Behavioral despair in mice after prenatal stress. J. Physiol. Biochem. 56, 77–82 (2000). https://doi.org/10.1007/BF03179902
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DOI: https://doi.org/10.1007/BF03179902