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The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

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Abstract

We studied the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OHDPAT), a 5-HT1A receptor agonist, on both Δ9-tetrahydrocannabinol-induced spatial memory impairment in an 8-arm radial maze, and the reduction of acetylcholine release in the dorsal hippocampus as assessed byin vivo microdialysis in rats. A 6 mg/kg i.p. dose of Δ9-tetrahydrocannabinol impaired spatial memory in the 8-arm radial maze and decreased the acetyl-choline release in the dorsal hippocampus. 8-OHD-PAT, at very low doses of 0.1–0.3 μg/kg, reversed both the impairment of spatial memory and the decrease in acetylcholine release induced by Δ9-tetrahydrocannabinol. These findings suggest that low doses of 8-OHDPAT may improve Δ9-tetrahy-drocannabinol-induced impairment of spatial memory by enhancing acetylcholine release in the dorsal hippocampus.

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Authors and Affiliations

  1. Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814-0180, Fukuoka, Japan

    Keiichiro Inui, Nobuaki Egashira, Kenichi Mishima, Akiko Yano, Nobuyoshi Hasebe, Kohji Abe, Kazuhide Hayakawa, Katsunori Iwasaki & Michihiro Fujiwara

  2. Department of School-Nursing, Kyushu Women’s Junior College, 807-8586, Kitakyushu, Japan

    Yoshiaki Matsumoto

  3. Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, 889-1692, Japan

    Tomoaki Ikeda

Authors
  1. Keiichiro Inui
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  2. Nobuaki Egashira
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  3. Kenichi Mishima
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  4. Akiko Yano
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  5. Yoshiaki Matsumoto
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  6. Nobuyoshi Hasebe
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  7. Kohji Abe
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  8. Kazuhide Hayakawa
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  9. Tomoaki Ikeda
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  10. Katsunori Iwasaki
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  11. Michihiro Fujiwara
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Corresponding author

Correspondence to Michihiro Fujiwara.

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Inui, K., Egashira, N., Mishima, K. et al. The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats. neurotox res 6, 153–157 (2004). https://doi.org/10.1007/BF03033218

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  • DOI: https://doi.org/10.1007/BF03033218

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