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Validation of CBF measurement with non-invasive microsphere method (NIMS) compared with autoradiography method (ARG)

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Abstract

The purpose of this study is to examine the correlation of measured regional cerebral blood flow (rCBF) by means of a new microsphere method (non-invasive microsphere method), to the autoradiography (ARG) method, which is an established quantification method for123I-IMP brain SPECT. The non-invasive microsphere (NIMS) method and ARG method were simultaneously applied to 30 patients, and quantified rCBF maps were calculated with each method. A significant correlation (r=0.70: p <0.001) was detected between mCBF values calculated with the NIMS and ARG methods. This new method seems to reliably quantify rCBF with brain SPECT.

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Authors and Affiliations

  1. Department of Radiology, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, 173-8605, Tokyo, Japan

    Tatsuro Kaminaga M.D., Natsuko Kunimatsu, Takashi Chikamatsu & Shigeru Furui

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  1. Tatsuro Kaminaga M.D.
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  2. Natsuko Kunimatsu
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  3. Takashi Chikamatsu
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  4. Shigeru Furui
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Correspondence to Tatsuro Kaminaga M.D..

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Kaminaga, T., Kunimatsu, N., Chikamatsu, T. et al. Validation of CBF measurement with non-invasive microsphere method (NIMS) compared with autoradiography method (ARG). Ann Nucl Med 15, 61–64 (2001). https://doi.org/10.1007/BF03012134

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  • DOI: https://doi.org/10.1007/BF03012134

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