Summary
A double-blind study is described, using diazepam, droperidol, and meperidine for premedication in children. The evaluation indicated that diazepam was the better drug.
Even though droperidol appears to be a very strong sedative, the children in this group were not as well prepared for surgery. However, since droperidol appears to have strong antiemetic properties, it can be concluded that it also can be useful as premedication to anaesthesia in children.
Although most children in the meperidine group appeared to be well prepared for surgery, with little or no sedation, we would consider this drug a poor premedication because of a high incidence of postoperative vomiting.
Diazepam had the added advantage in that postoperative emotional disturbances were less frequent than with meperidine. None of the active drugs used decreased the incidence of postoperative analgesic requirement.
Résumé
On a fait une étude à double inconnu, en se servant du diazépam, du dropéridol et de la mépéridine en prémédication chez les enfants. On a estimé que le diazépam était le meilleur produit.
Mâme si le dropéridol semble âtre un très puissant sédatif, les enfants de ce groupe n’étaient pas aussi bien préparés pour la chirurgie; cependant, comme le dropéridol semble avoir de puissantes propriétés anti émétiques, on peut conclure que le dropéridol peut aussi âtre utile comme agent de prémédication à ľanesthésie chez les enfants.
Bien que la plupart des enfants du groupe prémédiqué à la mépéridine ont semblé bien préparés pour la chirurgie, sans sédation ou presque, nous sommes enclins à considérer ce produit peu désirable en prémédication à cause de la fréquence consécutive de vomissements postopératoires.
Le diazépam avait aussi cet avantage que les troubles émotionnels postopératoires ont été moins fréquents que lors des prémédications à la mépéridine.
Aucun des produits utilisés n’a diminué le besoin ďanalgésiques postopératoires.
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McGarry, P.M.F. A double-blind study of diazepam, droperidol, and meperidine as premedication in children. Canad. Anaesth. Soc. J. 17, 157–165 (1970). https://doi.org/10.1007/BF03004666
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DOI: https://doi.org/10.1007/BF03004666