Abstract
We report a case of an atypical bronchial carcinoid showing sestamibi uptake. A 27-year-old man with Kallmann’s syndrome and hyperparathyroidism had parathyroid scintigraphy with99mTc-sestamibi. A focal uptake was observed on the right perihilar region, and this right perihilar mass was demonstrated on computed tomography and proved histologically to be an atypical bronchial carcinoid tumor. Factors which may explain the tumoral avidity for sestamibi are increased blood flow, transmembrane potentials of plasma and mitochondrial membranes and the relative number of mitochondria present in the cells of this carcinoid tumor. The importance of this case is the coincidence of an atypical carcinoid in a patient with significant failure of secondary sexual characteristics, right renal agenesis and bilateral anosmia associated with Kallmann’s syndrome.
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Bensch KG, Corrin B, Pariente R, Spencer H. Oat-cell carcinoma of the lung: its origin and relationship to bronchial carcinoid.Cancer 1968; 22: 1163–1172.
Goodner JT, Berg JW, Watson WL. The nonbenign nature of bronchial carcinoids and cylindromas.Cancer 1961; 14: 539.
Duh QY, Hybarger CP, Geist R, Gamsu G, Goodman PC, Gooding GA, et al. Carcinoids associated with multiple endocrine neoplasia syndromes.Am J Surg 1987; 154 (1): 142–148.
Yoshimoto K, Saito S. Clinical characteristics in multiple endocrine neoplasia type 1 in Japan: a review of 106 patients.Nippon Naibunpi Gakkai Zasshi 1991 20; 67 (7): 764–774.
Erdil TY, Ozker K, Kabasakal L, Kanmaz B, Sonmezoglu K, Atasoy KC, et al. Correlation of technetium-99m MIBI and thallium-201 retention in solitary cold thyroid nodules with postoperative histopathology.Eur J Nucl Med 2000; 27 (6): 713–720.
Grunwald F, Briele B, Biersack HJ. Non-131I-scintigraphy in the treatment and follow-up of thyroid cancer. Single-photon-emitters or FDG-PET?Q J Nucl Med 1999; 43 (3): 195–206.
Khalkhali I, Villanueva-Meyer J, Edell SL, Connolly JL, Schnitt SJ, Baum JK, et al. Diagnostic accuracy of99mTc-sestamibi breast imaging multicenter trial results.J Nucl Med 2000; 41 (12): 1973–1979.
Komori T, Narabayashi I, Matsui R, Sueyoshi K, Aratani T, Utsunomiya K. Technetium-99m MIBI single photon emission computed tomography as an indicator of prognosis for patients with lung cancer—preliminary report.Ann Nucl Med 2000; 14 (6): 415–420.
Maurea S, Acampa W, Varrella P, De Rosa V, Fimiani P, Abate G, et al. Tc-99m sestamibi imaging in the diagnostic assessment of patients with lymphomas: comparison with clinical and radiological evaluation.Clin Nucl Med 1998; 23 (5): 283–290.
Pinkas L, Robinson D, Halperin N, Mindlin L, Cohenpour M, Baumer M, et al.99mTc-MIBI scintigraphy in musculoskeletal tumors.J Nucl Med 2001; 42 (1): 33–37.
Desai SP, Yuille DL. Visualization of a recurrent carcinoid tumor and an occult distant metastasis by technetium-99m-sestamibi.J Nucl Med 1993; 34: 1748–1751.
Arbab AS, Koizumi K, Arai T, Araki T, Ozawa K, Hashimoto R, et al. Tc-99m MIBI uptake in a bronchial carcinoid tumor.Clin Nucl Med 1996; 21 (12): 1005–1006.
Lin KL, Chen CY, Hsu HH, Kao PF, Huang MJ, Wang HS. Ectopic ACTH syndrome due to thymic carcinoid tumor in a girl.J Pediatr Endocrinol Metab 1999; 12 (4): 573–578.
Hasleton PS, al-Saffar N. The histological spectrum of bronchial carcinoid tumours.Appl Pathol 1989; 7: 205–218.
Troncone L. Radiolabelled metaiodobenzylguanidine in the diagnosis of neural crest tumours. In:Nuclear Medicine in Clinical Diagnosis and Treatment, Murray IPC, Ell PJ, Strauss HW (eds), New York; Churchill Livingstone, 1994: 745–756.
Krenning EP, Kwekkeboom DJ, Reubi JC, Lamberts SWJ. Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1] octreotide. In:Nuclear Medicine in Clinical Diagnosis and Treatment, Murray IPC, Ell PJ, Strauss HW (eds), New York; Churchill Livingstone, 1994: 757–764.
Rosado de Christenson ML, Abbott GF, Kirejczyk WM, Galvin JR, Travis WD. Thoracic carcinoids: radiologicpathologic correlation.Radiographics 1999; 19 (3): 707–736.
Strouse PJ, Wang DC. Incidental detection of bronchogenic carcinoma during Tc-99m SESTAMIBI cardiac imaging.Clin Nucl Med 1993; 18 (5): 448–449.
Kitapci MT, Tastekin G, Turgut M, Caner B, Kars A, Barista I, et al. Preoperative localization of parathyroid carcinoma using Tc-99m MIBI.Clin Nucl Med 1993; 18: 217–218.
O’Driscoll CM, Baker F, Casey MJ, Duffy GJ. Localization of recurrent medullary thyroid carcinoma with technetium-99m-methoxyisobutylnitrile scintigraphy: a case report.J Nucl Med 1991; 32: 2281–2283.
Delmon-Moingeon LI, Piwnica-Worms D, Van Den Abbeele AD, Holman BL, Davison A, Jones AG. Uptake of the cation hexakis (2-methoxyisobutyl isonitrile) technetium-99m by human carcinoma cell linesin vitro.Cancer Res 1990; 50: 2198–2202.
Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutyl isonitrile) technetium (I) in cultured mouse fibroblasts.J Nucl Med 1990; 31: 1646–1653.
Aktolun C, Bayhan H, Kir M. Clinical experience with Tc-99m MIBI imaging in patients with malignant tumors. Preliminary results and comparison with Tl-201.Clin Nucl Med 1992; 17: 171–176.
Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex.Cancer Res 1993; 53: 977–984.
Freitas JE, Freitas AE. Parathyroid scintigraphy. In:Nuclear Medicine, Henkin RE, Boles GI, Halama JR, Karesh SM, Wagner RH, Zimmer AM (eds), St. Louis; Mosby, 1996: 877–885.
Greenspan BS, Brown ML, Dillehay GL, McBiles M, Sandler MP, Seabold JE, et al. Procedure guideline for parathyroid scintigraphy, Society of Nuclear Medicine.J Nucl Med 1998; 39: 1111–1114.
Martensson H, Bottcher G, Hambraeus G, Sundler F, Willen H, Nobin A. Bronchial carcinoids: an analysis of 91 cases.World J Surg 1987; 11: 356–364.
Rea F, Binda R, Spreafico G, Calabro F, Bonavina L, Cipriani A, et al. Bronchial carcinoids: a review of 60 patients.Ann Thorac Surg 1989; 47: 412–414.
Goldstraw P, Lamb D, McCormack RJ, Walbaum PR. The malignancy of bronchial adenoma.J Thorac Cardiovasc Surg 1976; 72: 309–314.
Jacobsson H, Wallin G, Werner S, Larsson SA. Technetium-99m methoxyisobutylisonitrile localizes an ectopic ACTH-producing tumour: case report and review of the literature.Eur J Nucl Med 1994; 21: 582–586.
Perez-Monte JE, Brown ML, Clarke MR, Watson CG, Carty SE. Parathyroid hyperplasia, thymic carcinoid and pituitary adenoma detected with technetium-99m-MIBI in MEN type I.J Nucl Med 1997; 38: 1767–1769.
Winters SJ. Clinical Disorders of the Testis. In:Endocrinology, DeGroot LJ, Besser M, Burger HG, Jameson JL, Loriaux DL, Marshall JC, Odell WD, Potts JT, Rubenstein AH (eds), Philadelphia; W.B. Saunders, 1995: 2377–2403.
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Yapar, Z., Kibar, M., Süran, A. et al. Coincidental visualization of an atypical bronchial carcinoid on Tc-99m-sestamibi scan in Kallmann’s syndrome. Ann Nucl Med 16, 61–65 (2002). https://doi.org/10.1007/BF02995293
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DOI: https://doi.org/10.1007/BF02995293