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Sustained bleeding from bites of hatchling leeches

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Abstract

Prolongation of haemostatic parameters in the host achieved by hatchlingHirudo medicinalis differs quantitatively but not qualitatively from those achieved by adult leeches. The duration and the rate of blood loss from the bite wounds, the gain in body weight of leeches and the duration of feeding each increase with successive feeding episodes. The mean duration of bleeding from bite wounds of hatchling leeches feeding for the first time on human volunteers was 43 min compared to 6 min from control incisions and 600 min in adult leeches. The mean ‘whole body’ concentration of hirudin in 2-week-old hatchlings was 10 antithrombin units (AT-U) compared to 285 AT-U in the head of each adult leech.

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References

  • Bergmann C, Dodt J, Kohler S et al. (1986) Chemical synthesis and expression of a gene coding for hirudin, the thrombin-specific inhibitor from the leechHirudo medicinalis. Biol Chem Hoppe Seyler 367:731–740

    PubMed  CAS  Google Scholar 

  • Harvey RP, Gegryse E, Stefani L et al. (1986) Cloning and expression of a cDNA coding for the anticoagulant hirudin from the blood-sucking leechHirudo medicinalis. Proc Natl Acad Sci USA 83:1084–1088

    Article  PubMed  CAS  Google Scholar 

  • Munro R, Hechtel FDP, Sawyer RT (1989) Sustained bleeding after a leech bite in the apparent absence of hirudin. Thromb Haemost 61:366–369

    PubMed  CAS  Google Scholar 

  • Munro R, Powell-Jones C, Sawyer RT (1991) Calin — a platelet adhesion inhibitor from the saliva of the medicinal leech. Blood Coag Fibrin 2(1):179–184

    Article  CAS  Google Scholar 

  • Sawyer RT, Lepont F, Stuart DK et al. (1981) Growth and reproduction of the giant glossiphonid leechHaementeria ghilianii. Biol Bull 160:322–331

    Article  Google Scholar 

  • Sawyer RT (1986) Leech Biology and Behaviour, Vol II. Oxford University Press, Oxford, pp. 573–575

    Google Scholar 

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Authors and Affiliations

  1. Haematology Department, Morriston Hospital, Swansea, UK

    R. Munro

  2. Biopharm (UK) Ltd., 2 Bryngwili Road, SA4 1XB, Hendy, Dyfed, UK

    R. T. Sawyer & F. O. P. Hechtel

  3. School of Biological Sciences, University College of Swansea, UK

    R. John

Authors
  1. R. Munro
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  2. R. T. Sawyer
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  3. F. O. P. Hechtel
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  4. R. John
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Munro, R., Sawyer, R.T., Hechtel, F.O.P. et al. Sustained bleeding from bites of hatchling leeches. Comp Haematol Int 2, 27–29 (1992). https://doi.org/10.1007/BF02984523

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  • DOI: https://doi.org/10.1007/BF02984523

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