Abstract
Bioassay-guided fractionation of CHCI3 extract from the fermentation broth of a spongeMycale plumose-derived actinomyceteSaccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1 ) against human cancer cell lines.
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Liu, R., Cui, CB., Duan, L. et al. Potentin Vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomyceteSac-charopolyspora sp. nov.. Arch Pharm Res 28, 1341–1344 (2005). https://doi.org/10.1007/BF02977899
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DOI: https://doi.org/10.1007/BF02977899