Abstract
Peonjahwan, an oriental traditional medicine composed of crude herbal drugs and animal tissues is bitter and poorly water-soluble. To mask the bitterness of peonjahwan and enhance the release of bilirubin, one of the crude active ingredients of peonjahwan, peonja dry elixir (PDE), was prepared using a spray-dryer after extracting the crude materials in ethanol-water solution. Coated peonja dry elixir (CPDE) was then prepared by coating the PDE with Eudragit acrylic resin. Panel assessed bitterness and release test of bilirubin from PDE and CPDE were carried out and compared with peonjahwan alone. PDE was found to have little effect upon the reduction of the bitterness of peonjahwan. However, the bitterness of CPDE was found to reduce to 1/4 of that of peonjahwan due to the encapsulation of crude active ingredients by the dextrin and Eudragit shell (P<0.05). The release rate of bilirubin from PDE and CPDE for 60 min increased about 3.5- and 2.5- fold, respectively, compared to peonjahwan at pH 1.2. It is concluded that CPDE, which masked the bitterness of peonjahwan and enhanced the release of bilirubin, is a preferable delivery system for peonjahwan.
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Ahn, H. J., Kim, K. M. and Kim, C. K., Enhancement of bioavailability of ketoprofen using dry elixir as a novel dosage form.Drug Dev. Ind. Pharm., 24 (7), 697–701 (1998).
Choi, J. Y., Shin, H. J., Choi, H. G., Kim, K. M., Lim, S. J. and Kim, C.K., Development of coated nifedipine dry elixir as a long acting oral delivery with enhanced bioavailability.Int. J. Pharm., accepted (1999).
Emmons, D. B., McGugan, W. A. and Elliott, J. A., Comparison of bitter flavor in cheese with quinine sulfate solutions.J. Diary Sci., 46, 798–800 (1963).
Hall, M. J., Bartoshuk, L. M., Cain, W. S. and Stevens, J. C., PTC taste blindness and the taste of caffeine.Nature, 253 (5491), 442–443 (1975).
Hashimoto, A., Yamasaki, K., Kokusenya, Y., Miyamoto, T. and Sato, T., Investigation of “signal” constituents for the evaluation of animal crude drugs. I. Free amino acids and total amino acids.Chem. Pharm. Bull., 42 (8), 1636–1641 (1994).
Horio, T. and Kawamura, Y., Influence of physical exercise on human preferences for various taste solutions.Chem. Senses, 23 (4), 417–421 (1998).
Katsuragi, Y., Sugiura, Y., Lee, C., Otsuji, K. and Kurihara, K., Selective inhibition of bitter taste of various drugs by lipoprotein.Pharma. Res., 12 (5), 658–662 (1995).
Kim, B. S., Gi, D. H., Go, C. S., Kim, C. B., Kim, J. K., Lee, C. K., Kim, K and Kim, Y. C., Peonjahwan and peonja capsule.Medical Index 6 th (Korea, Seoul), p. 1084 (1991).
Kim, C. K. and Choi, H. G., The mitigation of bitterness of zipeprol solution.Yakhak Hoeji (Korea), 31 (1), 42–44 (1987).
Kim, C. K. and Yoon, Y. S., Development of digoxin dry elixir as a novel dosage form using a spray-drying technique.J. Microencapsul., 25, 547–556 (1995).
Kim, C. K., Choi, J. Y., Yoon, Y. S., Gong, J. P., Choi, H. G., Kong, J. Y. and Lee, B. J., Preparation and evaluation of dry elixir for the enhancement of dissolution rate of poorly water-soluble drugs.Int. J. Pharm., 106, 25–32 (1994).
Kim, C. K., Yoon, Y. S. and Kong, J. Y., Preparation and evaluation of flurbiprofen dry elixir as a novel dosage form using a spray drying technique.Int. J. Pharm., 120, 21–31 (1995).
Kimura, M., Waki, I. and Ikeda, H., Fundamental research for the pharmacological activity of oriental drugs. 8. The potentiation of crude drug “Moschus” for catecholamines.Yakugaku Zasshi, 88 (2), 130–134 (1968).
Kimura, S., Sasaki, M., Kondo, Y., Jo, H., Kanbashi, T. and Koide, H., Study on radiosterilization of crude drug pill involving bezoar bovis-radiolysis of bilirubin and cholic acids in hydrous starch pellet.Radioisotopes, 30 (12), 669–73 (1981).
Lee, S. W., Kim, M. H. and Kim, C. K., Encapsulation of ethanol by spray drying technique: effects of sodium lauryl sulfate.Int. J. Pharm., 187 (2), 193–198 (1995).
Lieberman H. A. and Lachman L., Compression-Coated and Layer tablets,Pharmaceutical dosage forms, Marcel Dekker, Inc Press, New York and Basel, Volume 1, 187–212 (1980).
Lieberman H. A. and Lachman L., Mar, Kimura, S., Sasaki, M., Kondo, Y., Jo, H., Kanbashi, T. and Koide, H., Study on radiosterilization of crude drug pill involving bezoar bovis-radiolysis of bilirubin and cholic acids in hydrous starch pellet.Radioisotopes, 30 (12), 669–73 (1981).
Menting, L. C. and Hoogstad, B., Volatiles retention during the drying aqueous carbohydrate solution.J. Food Sci.,32, 87–90 (1967).
Menting, L. C., Hoogstad, B. and Thijssen, H. A. C., Diffusion coefficient of water and organic volatiles in carbohydrate-water systems.J. Food Technol.,5, 111–126 (1970).
Sato, J. and Kurusu, T., Process of manufacturing alcohol-containing solid matter.US Patent, 3786159 (1974).
Sato, J., Kurusu, T. and Ota, M., Process for the preparation of alcohol-containing powders.UK Patent, GB2110235A (1982).
Takahashi, K., Azuma, J., Park, S., Awata, N., Kishimoto, S., Namba, T. and Shaffer, S.W., Pharmacological study of a traditional Chinese medicine: effect of bezoar bovis on the irregular beating pattern of cultured mouse myocardial cells.Res. Commun. Chem. Pathol. Pharmacol. 63 (3), 317–330 (1989).
Tanaka, E., Funae, Y., Imaoka, S. and Misawa, S., Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3-methylcyclopentadecanone).Biochem. Pharmacol., 41 (3), 472–473 (1991).
Tanaka, E., Kurata, N., Kohno, M., Yoshida, T. and Kuroiwa, Y., Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats.Biochem. Pharmacol., 36 (24), 4263–4267 (1987).
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Choi, HG., Kim, CK. Application of dry elixir system to oriental traditional medicine: Taste masking of peonjahwan by coated dry elixir. Arch Pharm Res 23, 66–71 (2000). https://doi.org/10.1007/BF02976469
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DOI: https://doi.org/10.1007/BF02976469