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T-Cell receptor and autoimmune disease

  • T-Cell Receptors
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Summary

Since the genes encoding the TCR have been cloned, their structure, organization, pattern of rearrangement, diversification and expression in ontogeny have been classified. However, there are still many important questions to be addressed, such as the nature of thymic education, tolerance, the mechanism of MHC-restricted antigen recognition and the relation between TCR repertoire and autoimmunity. In the future, new approaches to study these issues, such as transgenic mice, X-ray crystallography, and severe combined immune deficiency mice reconstituted with human hematopoietic cells will lead to a more profound understanding of these questions. This will hopefully allow us to manipulate the immune response in different and more effective ways than are currently available.

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References

  1. Kaplan MH, Svec KH: Immunologic relation of streptococcal and tissue antigen. III. Presence in human sera of streptococcal antibody cross-reactive with heart tissue: Association with streptococcal infection, rheumatic fever and glomerulonephritis. J Exp Med 1964;119:651–665.

    Article  PubMed  CAS  Google Scholar 

  2. Endo K, Kasagi K, Konishi J, Ikekubo K, Okuno K, Takeda Y, Mori T, Torizuka K: Detection of properties of TSH-binding inhibitor immunoglobins in patients with Graves' disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab 1978; 46:734–739.

    Article  PubMed  CAS  Google Scholar 

  3. Theofilopoulos AN, Dixon JF: Etiopathogenesis of murine SLE. Immunol Rev 1981;55:179–216.

    Article  PubMed  CAS  Google Scholar 

  4. Manohar V, Brown EW, Leiserson M, Chused TM: Expression of Lyt-1 by a subset of B lymphocytes. J Immunol 1982;129:532–538.

    PubMed  CAS  Google Scholar 

  5. Steinberg BJ, Smathers PA, Frederikson K: Ability of the xid Gene to prevent autoimmunity in (NZB×NZW)F1 mice during the course of their natural history, after polyclonal stimulation, of following immunization with DNA. J Clin Invest 1982;70:587–597.

    Article  PubMed  CAS  Google Scholar 

  6. Tan EM: Autoantibodies to nuclear antigens (ANA): Their immunology and medicine. Adv Immunol 1982;33:167–240.

    Article  PubMed  CAS  Google Scholar 

  7. Smith HR, Steinberg AD: Autoimmunity: A perspective. Annu Rev Immunol 1983;1:175–210.

    Article  PubMed  CAS  Google Scholar 

  8. Painter C, Monestier M, Bonin B, Bona AC: Function and molecular studies of V genes expressed in autoantibodies. Annu Rev Immuno 1987;94:75–98.

    Article  Google Scholar 

  9. Carson D, Chen P, Fox IR, Kipps TJ, Jirik RF, Goldfien D, Silverman JG, Radoux V, Fong S: Rheumatoid factor and immune networks. Annu Rev Immunol 1987;5:109–126.

    Article  PubMed  CAS  Google Scholar 

  10. Allison JP, McIntyre BW, Bloch D: Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. J Immunol 1982;129: 2293–2300.

    PubMed  CAS  Google Scholar 

  11. Haskins K, Hannum C, White J, Roehm N, Kubo R, Kappler J, Marrack P: The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med 1984;160:452–471.

    Article  PubMed  CAS  Google Scholar 

  12. McIntyre BW, Allison JP: The mouse T cell receptor: Structural heterogeneity of molecules of normal T cell defined by xenoantiserum. Cell 1983; 34:739–746.

    Article  PubMed  CAS  Google Scholar 

  13. Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL: Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature 1983;303:808–810.

    Article  PubMed  CAS  Google Scholar 

  14. Yanagi Y, Yoshikai Y, Leggett CS, Aleksander I, Mak T: A human T cell specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 1984;308:145–149.

    Article  PubMed  CAS  Google Scholar 

  15. Hedrick SM, Cohen DI, Nielsen EA, Davis MM: Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 1984;308: 149–153.

    Article  PubMed  CAS  Google Scholar 

  16. Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S: Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 1984;309:757–762.

    Article  PubMed  CAS  Google Scholar 

  17. Theofilopoulos AN, Kofler R: Molecular aspects of autoimmunity. Immunol Today 1989;10:180–183.

    Article  PubMed  CAS  Google Scholar 

  18. Kumar V, Kono DH, Urban J, Leroy H: The T-cell receptor repertoire and autoimmune disease. Annu Rev Immunol 1989;7:657–682.

    Article  PubMed  CAS  Google Scholar 

  19. Wraith DC, McDevitt HO, Steinman L, Acha-Orbea H: T cell recognition as the target for immune intervention in autoimmune disease: Cell 1989;57:709–715.

    Article  PubMed  CAS  Google Scholar 

  20. Davis MM, Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature 1988;334: 395–402.

    Article  PubMed  CAS  Google Scholar 

  21. Chien YH, Gascoigne NRJ, Kavaler J, Lee NE, Davis MM: Somatic recombination in a murine T-cell receptor gene. Nature 1984;309:322–326.

    Article  PubMed  CAS  Google Scholar 

  22. Hayday AC, Saito H, Gillies SD, Kranz DM, Tanigawa G, Eisen HN, Tonegawa S: Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 1985;40:259–269.

    Article  PubMed  CAS  Google Scholar 

  23. Winoto A, Mjolsness S, Hood L: Genomic organization of the genes encoding mouse T-cell receptor a-chain. Nature 1985;316:832–836.

    Article  PubMed  CAS  Google Scholar 

  24. Kronenberg M, Siu G, Hood LE, Shastri N: The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol 1986;4:529–591.

    Article  PubMed  CAS  Google Scholar 

  25. Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S: A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 1984;312:36–40.

    Article  PubMed  CAS  Google Scholar 

  26. Arden B, Klotz JL, Siu G, Hood LE: Diversity and structure of genes of the a family of mouse T-cell antigen receptor. Nature 1985;316:783–787.

    Article  PubMed  CAS  Google Scholar 

  27. Becker DM, Patten, P, Chien Y-H, Yokota T, Eshhar Z, Giedlin M, Gascoigne NRJ, Goodnow C, Wold R, Arai K-I, Davis MM: Variability and repertoire size of T-cell receptor Va gene segments. Nature 1985;317:430–434.

    Article  PubMed  CAS  Google Scholar 

  28. Dembic A, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H, Steinmetz M: Transfer of specificity by murine α and βT-cell receptor genes. Nature 1986;320:232–238.

    Article  PubMed  CAS  Google Scholar 

  29. Singer PA, McEvilly RJ, Noonan DJ, Dixon JF, Theofilopoulos AN: Clonal diversity and T-cell receptor b-chain variable gene expression in enlarged lymph nodes of MRL-Ipr/Ipr lupus mice. Proc Natl Acad Sci USA 1986;83:7018–7022.

    Article  PubMed  CAS  Google Scholar 

  30. Chou HS, Nelson CA, Godambe SA, Chaplin DD, Loh DY: Germline organization of the murine T cell receptor B-chain genes. Science 1987;238: 545–548.

    Article  PubMed  CAS  Google Scholar 

  31. Lai E, Barth RK, Hood L: Genomic organization of the mouse T-cell receptor b-chain gene family. Proc Natl Acad Sci USA 1987;84:3846–3850.

    Article  PubMed  CAS  Google Scholar 

  32. Kappler JW, Tade T, White J, Kushnir E, Blackman M, Bill J, Roehm N, Marrack P: A T cell receptor VB segment that imparts reactivity to a class II major histocompatibility complex product. Cell 1987;49:263–271.

    Article  PubMed  CAS  Google Scholar 

  33. Patten P, Yokota T, Rothbard J, Chien Y-H, Arai K-I, Davis MM: Structure, expression and divergence of T-cell receptor B-chain variable regions. Nature 1984;312:40–46.

    Article  PubMed  CAS  Google Scholar 

  34. Barth RK, Kim BS, Lan NC, Hunkapiller T, Sobieck N, Winoto A, Gershenfeld H, Okada C, Hansburg D, Weissman IL, Hood L: The murine T-cell receptor uses a limited repertoire of expressed VB gene segments. Nature 1985;316:517–523.

    Article  PubMed  CAS  Google Scholar 

  35. Behlke MA, Spinella DG, Chou HS, Hartl DL, Loh DY: T-cell receptor B-chain expression: Dependence on relatively few variable region genes. Science 1985;229:566–570.

    Article  PubMed  CAS  Google Scholar 

  36. Kavaler J, Davis MM, Chien Y-H: Localization of a T-cell receptor diversity-region element. Nature 1984;310:421–423.

    Article  PubMed  CAS  Google Scholar 

  37. Siu G, Kronenberg M, Strauss E, Haars R, Mak TW, Hood L: The structure, rearrangement and expression of DB gene segments of the murine T-cell antigen receptor. Nature 1984;311:344–350.

    Article  PubMed  CAS  Google Scholar 

  38. Goverman J, Minard Shastri K, Hunkapiller T, Hansburg D, Sercarz E, Hood L: Rearranged βT cell receptor genes in helper T cell clone specific for lysozyme: No correlation between Vβ and MHC restriction. Cell 1985;40:859–867.

    Article  PubMed  CAS  Google Scholar 

  39. Gascoigne NRJ, Chien Y-H, Becker DM, Kavaler J, Davis MM: Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes. Nature 1984;310:387–391.

    Article  PubMed  CAS  Google Scholar 

  40. Hayday AC, Diamond JD, Tanigawa G, Heilig JS, Folsom V, Saito H, Tonegawa S: Unusual organization and diversity of T-cell receptor α-chain genes. Nature 1985;316:828–832.

    Article  PubMed  CAS  Google Scholar 

  41. Malissen M, Minard K, Mjolsness S, Kronenberg M, Goverman J, Hunkapiller T, Prystowsky MB, Yoshikai Y, Fitch F, Mak TW, Hood L: Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide. Cell 1984;37:1101–1110.

    Article  PubMed  CAS  Google Scholar 

  42. Hedrick SM, Nielsen EA, Kavaler J, Cohen DI, Davis MM: Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature 1984;308:153–158.

    Article  PubMed  CAS  Google Scholar 

  43. Dembic Z, Bannwarth W, Taylor B, Steinmetz M: The gene encoding the T-cell receptor α-chain maps close to the Np-2 locus on mouse chromosome 14. Nature 1985;314:271–273.

    Article  PubMed  CAS  Google Scholar 

  44. Kranz DM, Saito H, Disteche CM, Swisshelm K, Ptravtcheva D, Ruddle FH, Eisen HN, Tonegawa S: Chromosomal locations of murine T-cell receptor alpha-chain gene and the T-cell gamma-chain. Science 1985;227:941–945.

    Article  PubMed  CAS  Google Scholar 

  45. Chien Y-H, Ishikawa M, Kaplan KB, Elliot JF, Davis MM: A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 1987;327:677–682.

    Article  PubMed  CAS  Google Scholar 

  46. Caccia N, Kronenberg M, Saxe D, Haars R, Bruns G, Goverman J, Malissen M, Willard H, Yoshikai Y, Simon M, Hood L, Mak TW: The T-cell receptor b-chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell 1984;37: 1091–1099.

    Article  PubMed  CAS  Google Scholar 

  47. Lee NE, D'Eustachio P, Pravtcheva D, Ruddle FH, Hedrick SM, Davis MM: Murine T-cell receptor β-chain is encoded on chromosome 6.J Exp Med 1984;160:905–913.

    Article  PubMed  CAS  Google Scholar 

  48. Lindsten T, Lee NE, Davis MM: Organization of the T-cell antigen receptor β-chain locus in mice. Proc Natl Acad Sci USA 1987;84:7639–7643.

    Article  PubMed  CAS  Google Scholar 

  49. Lai E, Concannon P, Hood L: Conserved organization of the human and murine T-cell receptor β-chain families. Nature 1988;331:543–546.

    Article  PubMed  CAS  Google Scholar 

  50. Malissen M, McCoy C, Blanc D, Trucy J, Devaux C, Schmitt-Verhulst A-M, Fitch F, Hood L, Malissen B: Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements. Nature 1986;319:28–33.

    Article  PubMed  CAS  Google Scholar 

  51. Luria S, Gross G, Horowitz M, Givol D: Promoter and enhancer elements in the rearranged α chain gene of the human T cell receptor. EMBO 1987;6:3307–3312.

    CAS  Google Scholar 

  52. Winoto A, Baltimore D: Separate lineages of T cell expressing the αβ and γδ receptors. Nature 1989;338:430–432.

    Article  PubMed  CAS  Google Scholar 

  53. Krimpenfort P, Johg RD, Uematsu Y, Dembic Z, Ryser S, von Boehmer H, Steinmetz M, Berns A: Transcription or T cell receptor β-chain genes is controlled by a downstream regulatory element. EMBO J 1988;7:745–750.

    PubMed  CAS  Google Scholar 

  54. McDougall S, Peterson CL, Calame K: A transcriptionel enhancer 3′ of CB2 in the T cell receptor β locus. Science 1988;241:205–208.

    Article  PubMed  CAS  Google Scholar 

  55. Hashimoto Y: T cell receptor β gene has two downstream DNase I hypersensitive regions. J Exp Med 1989;169:2097–2107.

    Article  PubMed  CAS  Google Scholar 

  56. Winoto A, Baltimore D: A novel, inducible and T cell-specific enhancer located at the 3′ end of the T cell receptor α locus. EMBO J 1989;8:729–733.

    PubMed  CAS  Google Scholar 

  57. Uematsu Y, Ryser S, Dembic Z, Borgulya P, Krimpenfort P, Berns A, von Boehmer H, Steinmetz M: In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 1988;52:831–841.

    Article  PubMed  CAS  Google Scholar 

  58. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY: Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988;336:73–76.

    Article  PubMed  CAS  Google Scholar 

  59. Kronenberg M, Goverman J, Haars R, Malissen M, Kraig E, Phillips L, Delovitch T, Suciu-Joca N, Hood L: Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature 1985; 313:647–653.

    Article  PubMed  CAS  Google Scholar 

  60. Okazaki K, Sakano H: Thymocyte circular DNA excised from T cell receptor α-δ gene complex. EMBO J 1988;7:1669–1674.

    PubMed  CAS  Google Scholar 

  61. Fujimoto S, Yamagishi H: Isolation of an excision product of T-cell receptor α-chain gene rearrangements. Nature 1987;327:242–243.

    Article  PubMed  CAS  Google Scholar 

  62. Tonegawa S: Somatic generation of antibody diversity. Nature 1983;302:575–581.

    Article  PubMed  CAS  Google Scholar 

  63. Fink PJ: Veto cells. Annu Rev Immunol 1988;6: 115–137.

    Article  PubMed  CAS  Google Scholar 

  64. Quertermous T, Strauss W, Murre C, Dialynas DP, Strominger JL, Seidman JC: Human T-cell γ genes contain N segments and have marked junctional variability. Nature 1984;322:184–187.

    Article  Google Scholar 

  65. Heilig JS, Tonegawa S: T-cell r gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets. Proc Natl Acad Sci USA 1987;84:8070–8074.

    Article  PubMed  CAS  Google Scholar 

  66. Elliott JF, Rock EP, Patten PA, Davis MM, Chien Y-H: The adult T-cell receptor δ-chain is diverse and distinct from that of fetal thymocytes. Nature 1988;331:627–631.

    Article  PubMed  CAS  Google Scholar 

  67. Alt FW, Baltimore D: Joining of immunoglobulin heavy chain gene segments: Implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci USA 1982;79:4118–4122.

    Article  PubMed  CAS  Google Scholar 

  68. Winoto A, Urban JL, Lan NC, Goverman J, Hood L, Hansburg D: Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome c. Nature 1986;324:679–682.

    Article  PubMed  CAS  Google Scholar 

  69. Chien Y-H, Iwashima M, Wettstein DA, Kaplan KB, Elliott JF, Born W, Davis MM: T-cell receptor δ gene rearrangements in early thymocytes. Nature 1987;330:722–727.

    Article  PubMed  CAS  Google Scholar 

  70. Chien Y-H, Becker D, Lindsten T, Okamura M, Cohen D, Davis MM: A third type of murine T-cell receptor gene. Nature 1984;312:36–40.

    Article  Google Scholar 

  71. Fabbi M, Acuto O, Smart JW, Reinhertz EI: Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin. Nature 1984;312:269–271.

    Article  PubMed  CAS  Google Scholar 

  72. Novotny J, Tonegawa S, Saito H, Kranz DM, Eisen HN: Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains. Proc Natl Acad Sci USA 1986;83:742–746.

    Article  PubMed  CAS  Google Scholar 

  73. Fink PJ, Matis LA, McElligott DL, Bookman M, Hedrick SM: Correlations between T-cell specificity and the structure of the antigen receptor. Nature 1986;321:219–226.

    Article  PubMed  CAS  Google Scholar 

  74. van den Elsen P, Shepley B-A, Borst J, Coligan JE, Markham AF, Orkin S, Terhorst C: Isolation of cDNA clones encoding the 20k T3 glycoprotein of human T-cell receptor complex. Nature 1984;312: 413–418.

    Article  PubMed  Google Scholar 

  75. van den Elsen P, Shepley B-A, Cho M, Terhorst C: Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature 1985;314:542–544.

    Article  PubMed  Google Scholar 

  76. Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C: Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature 1986;321:431–434.

    Article  PubMed  CAS  Google Scholar 

  77. Krissansen GW, Owen MJ, Verbi W, Crumpton MJ: Primary structure of the T3 g subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 γ and δ subunits. EMBO J 1986;5:1799–1808.

    PubMed  CAS  Google Scholar 

  78. Krissansen GW, Owen MJ, Fink PJ, Crumpton MJ: Molecular cloning of the cDNA encoding the T3g subunit of the mouse T3/T cell antigen receptor complex. J Immunol 1987;138:3513–3518.

    PubMed  CAS  Google Scholar 

  79. Weissman AM, Baniyash M, Hou D, Samelson LE, Burgess WH, Klausner RD: Molecular cloning of the zeta chain of the T cell antigen receptor. Science 1988;239:1018–1021.

    Article  PubMed  CAS  Google Scholar 

  80. Chothia C, Lesk AM: Canonical structure for the hypervariable regions of immunoglobulin. J Mol Biol 1987;196:901–917.

    Article  PubMed  CAS  Google Scholar 

  81. Novotny J, Haber E: Structural invariants of antigen binding: Comparison of immunoglobulin VL-VH and VL-VL domain dimers. Proc Natl Acad Sci USA 1985;82:4592–4596.

    Article  PubMed  CAS  Google Scholar 

  82. Kindred B, Shreffler DC: H-2 dependence of cooperation between T and B cells in vivo. J Immunol 1982;109:940–943.

    Google Scholar 

  83. Katz DH, Hamaoka T, Benacerraf B: Cell interactions between histoincompatible T and B lymphocytes II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogenic donor strains in humoral response to hapten protein conjugates. J Exp Med 1983;137:1405–1418.

    Article  Google Scholar 

  84. Rosenthal AS, Shevach EM: Function of macrophages in antigen recognition by guinea pig T lymphocytes. J Exp Med 1983;138:1194.

    Article  Google Scholar 

  85. Zinkernagel RM, Dohorty PC: Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngenic or semi-allogenic system. Nature 1984;248:701–702.

    Article  Google Scholar 

  86. Kappler JW, Skidmore B, White J, Marrack P: Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas; Lack of independent antigen and H-2 recognition. J Exp Med 1981;153:1198–1214.

    Article  PubMed  CAS  Google Scholar 

  87. Infante AJ, Infante PD, Gillis S, Fathman CG: Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell cloned. J Exp Med 1982;155:1100.

    Article  PubMed  CAS  Google Scholar 

  88. Hunig TR, Bevan MJ: Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered self hypothesis. J Exp Med 1982;155:988.

    Article  Google Scholar 

  89. Heber-Katz E, Schwartz RH, Matis LA, Hannum C, Fairwell T, Appella E, Hansburg D: Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med 1982;155:1086–1099.

    Article  PubMed  CAS  Google Scholar 

  90. White J, Haskins KM, Marrack P, Kappler J: Use of I region-restricted, antigen specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies. J Immunol 1983;130: 1033–1037.

    PubMed  CAS  Google Scholar 

  91. Samleson LE, Schwartz RH: T cell clone specific alloantisera that inhibit or stimulate antigen-induced T cell activation. J Immunol 1983;131: 2645–2650.

    Google Scholar 

  92. Samelson LE, Schwartz RH: The use of antisera and monoclonal antibodies to identify the antigen-specific T cell receptor from pigeon cytochrome c-specific T cell hybrids. Immunol Rev 1983;76:59.

    Article  PubMed  CAS  Google Scholar 

  93. Kaye J, Porcelli S, Tite J, Hones B, Janeway CA: Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J Exp Med 1983;158:836–856.

    Article  PubMed  CAS  Google Scholar 

  94. Meuer SC, Hodgdon JC, Hussey RE, Protentis JP, Schlossman SF, Reinherz EL: Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med 1983; 158:988–993.

    Article  PubMed  CAS  Google Scholar 

  95. Haskins K, Kubo R, White J, Pigeon M, Kappler J, Marrack P: The major hiostocompatibility complex restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J Exp Med 1983;157:1149.

    Article  PubMed  CAS  Google Scholar 

  96. Samelson LE, Germain RN, Schwartz RH: Monoclonal antibodies against the antigen receptor on a cloned T cell Hybrid. Proc Natl Acad Sci 1983;80:727.

    Article  Google Scholar 

  97. Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman SF, Reinherz EL: Clonotypic structure involved in antigen-specific human T cell function. J Exp Med 1983;157:705.

    Article  PubMed  CAS  Google Scholar 

  98. Acuto O, Hussey RE, Fitzgerald KA, Protenis JP, Meuer SC, Schlossman SF, Reinhertz EL: The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors. Cell 1983;34:739.

    Article  Google Scholar 

  99. Haskins K, Kappler J, Marrack P: The major histocompatibility complex-restricted antigen receptor on T cells. Annu Rev Immunol 1984;2: 51–66.

    PubMed  CAS  Google Scholar 

  100. Yague J, White J, Coleclough C, Kappler J, Palmer E, Marrack P: The T cell receptor: The α and β chains define idiotype, and antigen and MHC specifity. Cell 1985;42:81–87.

    Article  PubMed  CAS  Google Scholar 

  101. Saito T, Weiss A, Miller J, Norcross MA, Germain RN: Specific antigen-Ia activation of transfected human T cells expressing murine Ti αβ-human T3 receptor complexes. Nature 1987; 325:125–130.

    Article  PubMed  CAS  Google Scholar 

  102. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987;329:506–512.

    Article  PubMed  CAS  Google Scholar 

  103. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC: The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987; 329:512–518.

    Article  PubMed  CAS  Google Scholar 

  104. Brown JH, Jardetzky T, Saper MA, Samraoui B, Bjorkman PJ, Wiley DC: A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 1988;332: 845–850.

    Article  PubMed  CAS  Google Scholar 

  105. Hedrick SM, Engel I, McElligott DL, Fink PJ, Hsu ML, Hansburg D, Matis LA: Selection of amino acid sequences in the beta chain of the T cell antigen. Science 1988;239:1541–1544.

    Article  PubMed  CAS  Google Scholar 

  106. Tan K-N, Datlof BM, Gilmore JA, Kronman AC, Lee JH, Maxam AM, Rao A: The T cell receptor Vα3 gene segment is associated with reactivity top-azobenzenearsonate. Cell 1988; 54:247–261.

    Article  PubMed  CAS  Google Scholar 

  107. Saito, T, Germain RN: Predictable acquisition of a new MHC recognition specificity following expression of a transfected T-cell receptor B-chain gene. Nature 1987;329:256–259.

    Article  PubMed  CAS  Google Scholar 

  108. Marrack P, Kappler J: T cells can distinguish between allogeneic major histocompatibility complex products on different cell types. Nature 1988;332:840–843.

    Article  PubMed  CAS  Google Scholar 

  109. Wofsy D, Seaman WE: Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med 1985; 161:378–391.

    Article  PubMed  CAS  Google Scholar 

  110. Ranges GE, Sriram S, Cooper SM: Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med 1985;162: 1105–1110.

    Article  PubMed  CAS  Google Scholar 

  111. Taurog JD, Sanberg GP, Mahowald ML: The cellular basis of adjuvant arthritis. I. Enhancement of cell-mediated passive transfer by concanavalin A and by immunosuppressive pretreatment of recipient. Cell Immunol 1983;75:271–282.

    Article  PubMed  CAS  Google Scholar 

  112. Maron R, Zerubavel R, Friedman A, Cohen IR: T-lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune tyroiditis in mice. J Immunol 1983;131:2316–2322.

    PubMed  CAS  Google Scholar 

  113. Rossini AA, Mordes JP, Like AA: Immunology of insulin dependent diabetes mellitus. Annu Rev Immunol 1985;3:289–320.

    Article  PubMed  CAS  Google Scholar 

  114. Zamvil SS, Mitchell DJ, Powell MB, Sakai K, Rothbard JB, Steinmann L: Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells. J Exp Med 1988;168: 1181–1186.

    Article  PubMed  CAS  Google Scholar 

  115. Raine CS, Snyder DH, Valsamis MP, Stone SH: Chronic experimental allergic encephalomyelitis in inbred guinea pigs. An ultrastructural study. Lab Invest 1974;31:369–380.

    PubMed  CAS  Google Scholar 

  116. Lassmann H, Wisniewski HM: Chronic relapsing experimental allergic encephalomyelitis. Arch Neurol 1979;36:490–497.

    PubMed  CAS  Google Scholar 

  117. Gasser DL, Silver WK: Genetic determinants of immunological responsiveness. Adv Immunol 1974;18:1–66.

    Article  PubMed  CAS  Google Scholar 

  118. Bernard CCA: Experimental autoimmune encephalomyelitis in mice: Genetic control of susceptibility. J Immunogenet 1976;3:263–274.

    Article  PubMed  CAS  Google Scholar 

  119. Lando Z, Teitelbaum D, Arnon R: Genetic control of susceptibility to experimental allergic encephalomyelitis in mice. Immunogenetics 1979; 9:435–442.

    Article  Google Scholar 

  120. Ben-nun A, Lado Z: Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice. J Immunol 1983;130:1205–1209.

    PubMed  CAS  Google Scholar 

  121. Hauser SL, Weiner HL, Bhan AK, Shapiro ME, Che M, Aldrich RW, Letvin NL: Lyt-1 cells mediated acute murine experimental allergic encephalomyelitis. J Immunol 1984;133:2288–2290.

    PubMed  CAS  Google Scholar 

  122. Fritz RB, Skeen MJ, Chou C-HJ, Garcia M, Egorov IK: Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J Immunol 1985;134: 2328–2332.

    PubMed  CAS  Google Scholar 

  123. Sakai K, Namikawa T, Kunishima T, Yamanouchi K, Tabira T: Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell ines and clones in euthymic and athymic mice. J Immunol 1986;137:1527–1531.

    PubMed  CAS  Google Scholar 

  124. Endoh M, Tabira T, Kunishima T, Sakai K, Yamamura T, Taketomi T: DM-20, A proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephlomyelitis in mice. J Immunol 1986;137:3822–3835.

    Google Scholar 

  125. Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steiman L, Rothbard JB: T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 1986;324:258–260.

    Article  PubMed  CAS  Google Scholar 

  126. Sakai K, Zamvil SS, Mitchell DJ, Lim M, Rothbard JB, Steinman L: Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J Neuroimmunol 1988;19:21–32.

    Article  PubMed  CAS  Google Scholar 

  127. Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB: A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J Immunol 1988;141:1126–1130.

    PubMed  CAS  Google Scholar 

  128. Kono DH, Urban JL, Horvath SJ, Ando DG, Saavedra RA, Hood L: Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice. J Exp Med 1988;168:213–227.

    Article  PubMed  CAS  Google Scholar 

  129. Sriram S, Steinman L: Anti-I-A antibody suppresses active encephalomyelitis: Treatment model for disease linked to IR genes. J Exp Med 1983;158:1362–1367.

    Article  PubMed  CAS  Google Scholar 

  130. Waldor MK; Sriram MK, Hardy RL, Herzenberg A, Herzenberg LA, Lanier L, Lim M, Steinman L: Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science 1985;227:415–417.

    Article  PubMed  CAS  Google Scholar 

  131. Sriram S, Roberts CA: Treatment of established chronic relapsing experimental allergic encephalomyelitis with anti-L3T4 antibodies. J Immunol 1986;136:4464–4469.

    PubMed  CAS  Google Scholar 

  132. Perry LL, Dorf ME, Bach BA, Benacerraf B, Greene MI: Mechanism of regulation of cell mediated immunity. VIII. Anti-I-A alloantisera interferes with induction and expression of T cell mediated immunity to cell bound antigen in vivo. Clin Immunol Immunopathol 1980;15: 279–292.

    Article  PubMed  CAS  Google Scholar 

  133. Perry LL, Greene MI: Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies. J Exp Med 1982; 156:480–491.

    Article  PubMed  CAS  Google Scholar 

  134. Zamvil S, Nelson P, Trotter J, Mitchell D, Knobler R, Fritz R, Steinman L: T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 1985;317:355–358.

    Article  PubMed  CAS  Google Scholar 

  135. Satoh J, Sakai K, Emdoh M, Koike F, Kunishita T, Namikawa T, Yamamura T, Tabira T: Experimental allergic encephalomyelitis mediated by murine encephalitogenic T cell lines specific for myelin proteolipid apoprotein. J Immunol 1987; 138:179–184.

    PubMed  CAS  Google Scholar 

  136. Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Trausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L: Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54:263–273.

    Article  PubMed  CAS  Google Scholar 

  137. Urban JL, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercarz EE, Hood L: Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 1988;54: 577–592.

    Article  PubMed  CAS  Google Scholar 

  138. Burns FR, Li X, Shen N, Offner H, Chou YK, Vandenbark AA, Heber-Katz E: Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 1989;169:27–39.

    Article  PubMed  CAS  Google Scholar 

  139. Owhashi M, Heber-Katz E: Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein. J Exp Med 1988;168: 2153–2164.

    Article  PubMed  CAS  Google Scholar 

  140. Haqqi TM, Banerjee S, Behlke MA, Dungeon G, Loh DY, Stuart J, Luthra HS, David CS: Vβ6 gene of T cell receptor may be involved in type II collagen induced arthritis in mice. FASEB J 1988;2:A661.

    Google Scholar 

  141. Vanderbark AA, Haskim G, Ottrer H: Immunization with a synthetic T cell receptor V region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989;341:541–544.

    Article  Google Scholar 

  142. Oksenberg JR, Sherritt M, Begovich AB, Erlich HA, Bernard CC, Cavalli-Sforza LL, Steinman L: T-cell receptor Vα and Cα alleles associated with multiple sclerosis and myasthenia gravis. Proc Natl Acad Sci USA 1989;86:988–992.

    Article  PubMed  CAS  Google Scholar 

  143. Millward BA, Welsh KI, Leslie RDG, Pyke DA, Demaine AG: T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes. Clin Exp Immunol 1987;70:152–157.

    PubMed  CAS  Google Scholar 

  144. Weetman AP, So AK, Roe C, Walport MJ, Foroni L: T-cell a chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' disease. Hum Immunol 1987;20: 167–173.

    Article  PubMed  CAS  Google Scholar 

  145. Seboun E, Robinson T, Doolittle TH, Cilulla TA, Kindt TJ, Hauser SL: A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex. Cell 1989;57:1095–1100.

    Article  PubMed  CAS  Google Scholar 

  146. Hafler DD, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL: Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 1988;167:1313–1322.

    Article  PubMed  CAS  Google Scholar 

  147. Stamenkovic I, Stegagno M, Wright K, Krane S, Amento EP, Colvin RB, Doquesnoy R, Kurnick JT: Clonal dominance among T-lymphocyte infiltrate in arthritis. Proc Natl Acad Sci USA 1988;85:1179–1183.

    Article  PubMed  CAS  Google Scholar 

  148. Kotzin BL, Barr VL, Palmer E: A large deletion within the T-cell receptor beta-chain gene complex in New Zealand White Mice. Science 1985; 229:167–171.

    Article  PubMed  CAS  Google Scholar 

  149. Noonan DJ, Kofler R, Singer PA, Cardenas G, Dixon FJ, Theofilopoulos AN: Delineation of a defect in T cell receptor β genes of NZW mice predisposed to autoimmunity. J Exp Med 1986; 163:644–653.

    Article  PubMed  CAS  Google Scholar 

  150. Yanagi Y, Hirose S, Nagasawa R, Shirai T, Mak TW, Tada T: Does the deletion within T cell receptor β-chain gene of NZW mice contribute to autoimmunity in (NZB/NZW)F1 mice? Eur J Immunol 1986;16:1179–1182.

    Article  PubMed  CAS  Google Scholar 

  151. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGH, Gamble R: In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985;313:353–360.

    PubMed  CAS  Google Scholar 

  152. Hanafusa T, Pjjol-Borrell R, Chiovato L, Russell RCG, Doniach D, Bottazzo GF: Aberrant expression of HLA-DR antigen on thymocytes in Grave's disease: Relevance for autoimmunity. Lancet 1983;ii:1111–1115.

    Article  Google Scholar 

  153. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL: The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 1988;241:1632–1639.

    Article  PubMed  CAS  Google Scholar 

  154. Yui K, Komori S, Katsumata M, Siegel RM, Greene MI: Proc Natl Acad Sci USA 1990;87: 7135–1739.

    Article  PubMed  CAS  Google Scholar 

  155. Wadsworth S, Yui K, Siegel RM, Tenenholz DE, Hirsch JA, Greene MI: Origin and selection of peripheral CD-CD8− T cells bearing α/β T cell antigen receptors in autoimmunegld mice. Eur J Immunol 1990;20:723–730

    Article  PubMed  CAS  Google Scholar 

  156. Samelson LE, Phillips AF, Luong ET, Klausner RD: Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci USA 1990;87:4358–4367.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pathology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pa, USA

    Shinji Komori, Richard M. Siegel, Katsuyuki Yui, Makoto Katsumata & Mark I. Greene

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  1. Shinji Komori
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Komori, S., Siegel, R.M., Yui, K. et al. T-Cell receptor and autoimmune disease. Immunol Res 9, 245–264 (1990). https://doi.org/10.1007/BF02935525

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