Skip to main content
Log in

Tumor necrosis factor and immunopathology

  • Immunology and Immunopathology of Tumor Necrosis Factor, Symposium
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Old, L.J.: Tumor necrosis factor. Scient. Am.258: 41–49 (1988).

    Article  Google Scholar 

  2. Yamasu, K.; Onoe, H.; Soma, G.; Oshima, H.; Mizuno, D.: Secretion of tumor necrosis factor during fetal and neonatal development of the mouse: ontogenic inflammation. J. biol. Response Modif.8: 644–655 (1989).

    CAS  Google Scholar 

  3. Le, J.; Vilcek, J.: Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities. Lab. Invest.561: 234–248 (1987).

    Google Scholar 

  4. Beutier, B.; Cerami, A.: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. A. Rev. Biochem.57: 505–518 (1988).

    Google Scholar 

  5. Dinarello, C.A.: Interleukin-1 and its biologically related cytokines. Adv. Immunol.44: 153–204 (1989).

    PubMed  CAS  Google Scholar 

  6. Beutler, B.; Milsark, I.W.; Cerami, A.C.: Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science229: 869–871 (1985).

    PubMed  CAS  Google Scholar 

  7. Tracey, K.J.; Beutler, B.; Lowry, S.F.; Merryweather, J.; Wolpe, S.; Milsark, I.W.; Hariri, R.J.; Fahey, T.J.; Zentella, A.; Albert, J.D.; Shires, G.T.; Cerami, A.: Shock and tissue injury induced by recombinant human cachectin. Science234: 470–474 (1986).

    PubMed  CAS  Google Scholar 

  8. Sugarman, B.J.; Aggarwal, B.B.; Hass, P.E.; Figari, I.S.; Palladino, M.A.; Shepard, M.H.: Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science230: 943–945 (1985).

    PubMed  CAS  Google Scholar 

  9. Selmaj, K.W.; Farooq, M.; Norton, W.T.; Raine, C.S.; Brosnan, C.F.: Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J. Immun.144: 239–135 (1990).

    Google Scholar 

  10. Branch, D.R.; Turner, A.R.; Larry, L.J.: Synergistic stimulation of macrophage proliferation by the monokines tumor necrosis factor alpha and colony stimulating factor 1. Blood73: 307–311 (1989).

    PubMed  CAS  Google Scholar 

  11. Yokota, S.; Geppert, T.D.; Lipsky, P.E.: Enhancement of antigen and mitogen induced human T lymphocyte proliferation by tumor necrosis factor-alpha. J. Immun.140: 531–536 (1988).

    PubMed  CAS  Google Scholar 

  12. Ruff, M.R.; Gifford, G.E.: Purification and physico-chemical characterization of rabbit tumor necrosis factor. J. Immun.125: 1671–1677 (1980).

    PubMed  CAS  Google Scholar 

  13. Schuger, L.; Varani, J.; Marks, R.M.; Kunkel, S.L.; Johnson, K.J.; Ward, P.A.: Cytotoxicity of tumor necrosis factor-alpha for human umbilical vein endothelial cells. Lab. Invest.61: 62–68 (1989).

    PubMed  CAS  Google Scholar 

  14. Selmaj, K.W.; Raine, C.S.: Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol.23: 338–346 (1988).

    Google Scholar 

  15. Taverne, J.; Rayner, D.C.; van der Meide, P.H.; Lydyard, P.M.; Bidey, S.P.; Cooke, A.: Cytotoxicity of tumor necrosis factor for thyroid epithelial cells and its regulation by interferon-gamma. Eur. J. Immunol.17: 1855–1858 (1987).

    PubMed  CAS  Google Scholar 

  16. Palombello, V.J.; Vilcek, J.: TNF is a bifunctional growth regulator in Balb/c 3T3 cells (abstract). 2nd Int. Conf. on Tumor Necrosis Factor and Rel. Cytokines. WA210: (1989).

  17. Talmadge, J.E.; Bowersox, O.; Tribble, H.; Lee, S.H.; Shepard H.M.; Liggit, D.: Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors. Am. J. Path.128: 410–424 (1987).

    PubMed  CAS  Google Scholar 

  18. Tracey, K.J.; Wei, H.; Manogue, K.R.; Fong, Y.; Hesse, D.G.; Nguyen, H.T.; Kuo, G.C.; Beutler, B.; Cotran, R.S.; Cerami, A.; Lowry, S.F.: Cacbectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J. exp. Med.167: 1211–1227 (1988).

    PubMed  CAS  Google Scholar 

  19. Remick, D.G.; Kunkel, R.G.; Larrick, J.W.; Kunkel, S.L.: Acute in vivo effects of human recombinant tumor necrosis factor. Lab. Invest.56: 583–590 (1987).

    PubMed  CAS  Google Scholar 

  20. Piguet, P.F.; Grau, G.E.; Vassalli, P.: Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis. Am. J. Path.136: 103–110 (1990).

    PubMed  CAS  Google Scholar 

  21. Philip, R.; Epstein, L.B.: Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature323: 86–89 (1986).

    PubMed  CAS  Google Scholar 

  22. Seelentag W.K.; Mermod, J.J.; Montesano, R.; Vassalli, P.: Additive effects of interleukin-1, and tumor necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony stimulating factor mRNA in human endothelial cells. Eur. molec. Biol. Org. J.6: 2261–2265 (1987).

    CAS  Google Scholar 

  23. Hajjar, K.A.; Hajjar, D.P.; Silverstein, R.L.; Lachmann, R.L.: Tumor necrosis factor mediated release of platelet derived growth factor from cultured endothelial cells. J. exp. Med.166: 235–245 (1987).

    PubMed  CAS  Google Scholar 

  24. Le, J.M.; Vilcek, J.: Interleukin-6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab. Invest.61: 588–602 (1989).

    PubMed  CAS  Google Scholar 

  25. Strieter, R.M.; Kunkel, S.L.; Showell, H.J.; Remick, D.G.; Phan, S.H.; Ward, P.A.; Marks, R.M.: Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1-beta. Science243: 1467–1469 (1989).

    PubMed  CAS  Google Scholar 

  26. Dayer, J.M.; Beutler, B.; Cerami, A.: Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J. exp. Med.162: 2163–2168 (1985).

    PubMed  CAS  Google Scholar 

  27. Bevilacqua, M.P.; Pober, J.S.; Majeau, G.R.; Fiers, W.; Cotran, R.S.; Gimbrone, M.A.: Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc. natn. Acad. Sci. USA83: 4533–4537 (1986).

    CAS  Google Scholar 

  28. Kishimoto, T.K.; Larson, R.S.; Corbi, A.L.; Dustin, M.L.; Staunton, D.E.; Springer, T.A.: The leukocyte integrins. Adv. Immunol.46: 149–182 (1989).

    Article  PubMed  CAS  Google Scholar 

  29. Ranges, G.E.; Zlotnik A.; Espevik, T.; Dinarello, C.A.; Cerami, A.; Palladino, M.A., Jr.: Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines. J. exp. Med.167: 1472–1478 (1988).

    PubMed  CAS  Google Scholar 

  30. Kehrl, J.H.; Miller, A.; Fauci, A.S.: Effect of tumor necrosis factor alpha on mitogen-activated human B cells. J. exp. Med.166: 786–791 (1987).

    PubMed  CAS  Google Scholar 

  31. Shalaby, M.R.; Espevik, T.; Rice, G.C.; Ammann, A.J.; Figari, I.S.; Ranges, G.E.; Palladino, M.A.: The involvement of human tumor necrosis factors-alpha and beta in the mixed lymphocyte reaction. J. Immun.141: 499–503 (1988).

    PubMed  CAS  Google Scholar 

  32. Scheurich, P.; Thoma, B.; Ucer, U.; Pfizenmaier, K.: Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha mediated enhancement of T cell responses. J. Immun.138: 1786–1790 (1987).

    PubMed  CAS  Google Scholar 

  33. Ghiara, P.; Boraschi, D.; Nencioni, L.; Ghezzi, P.; Tagliabue, A.: Enhancement of in vivo immune response by tumor necrosis factor. J. Immun.139: 3676–3679 (1987).

    PubMed  CAS  Google Scholar 

  34. Piguet, P.F.; Grau, G.E.; Allet, B.; Vassalli, P.: Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J. exp. Med.166: 1280–1289 (1987).

    PubMed  CAS  Google Scholar 

  35. Jacob, C.O.; Fronek, Z.; Lewis, G.D.; Koo, M.; Hansen, J.A.; McDevitt, H.O.: Heritable major histocompatibility complex class-II-associated differences in production of tumor necrosis factor-alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc. natn. Acad. Sci. USA87: 1233–1237 (1990).

    CAS  Google Scholar 

  36. Jongeneel, C.V.; Acha-Orbea, H.; Blankenstein, T.: A polymorphic microsatellite in the tumor necrosis factor-alpha promoter identifies an allelle unique to the NZW mouse strain. J. exp. Med. (in press).

  37. Svejgaard, A.; Platz, P.; Ryder, L.P.: HLA and disease 1982: a survey. Immunol. Rev.70: 193–218 (1983).

    PubMed  CAS  Google Scholar 

  38. Young, J.D.; Liu, C.C.; Butler, G.; Cohn, Z.A.; Galli, S.J.: Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc. natn. Acad. Sci. USA84: 9175–9179 (1987).

    CAS  Google Scholar 

  39. Granato, D.A.; Piguet, P.F.: A mouse monoclonal IgF antibody anti-bovine milk beta-lactoglobulin allows studies of allergy in the gastro-intestinal tract. Clin. exp. Immunol.63: 703–710 (1986).

    PubMed  CAS  Google Scholar 

  40. Warren, J.S.; Yabroff, K.R.; Remick, D.G.; Kunkel, S.L.; Chensue, S.W.; Kunkel, R.G.; Johnson, K.J.; Ward, P.A.: Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J. clin. Invest.84: 1873–1882 (1989).

    PubMed  CAS  Google Scholar 

  41. Brennan, D.C.; Yui, M.A.; Wuthrich, R.P.; Kelley, V.E.: Tumor necrosis factor and IL-1 in New-Zealand Black White mice: enhanced gene expression and acceleration of renal injury. J. Immun.143: 3470–3475 (1989).

    PubMed  CAS  Google Scholar 

  42. Boswell, J.M.; Yui, M.A.; Burt, D.W.; Kelley, V.E.: Increased tumor necrosis factor and IL-1-beta gene expression in the kindeys of mice with lupus nephritis. J. Immun.141: 3050–3054 (1988).

    PubMed  CAS  Google Scholar 

  43. Debets, J.M.H.; Vandewinkel, J.G.J.; Ceuppens, J.L.; Dieteren, I.E.M.; Buurman, W.A.: Crosslinking of both Fc-Gamma-Ri and Fc-Gamma-Rii induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc-Gamma-R interactions; functional activation of Fc-Gamma-Rii by treatment with proteases or neuraminidase. J. Immun.144: 1304–1310 (1990).

    PubMed  CAS  Google Scholar 

  44. Grau, G.E.; Piguet, P.F.; Vassalli, P.; Lambert, P.H.: Tumor necrosis factor and other cytokines in cerebral malaria: experimental and clinical data. Immunol. Rev.112: 49–70 (1989).

    PubMed  CAS  Google Scholar 

  45. Grau, G.E.; Fajardo, L.F.; Piguet, P.F.; Allet, B.; Lambert, P.H.; Vassalli, P.: Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science237: 1210–1212 (1987).

    PubMed  CAS  Google Scholar 

  46. Grau, G.E.; Taylor, T.E.; Molyneux, M.E.; Wirima J.J.; Vassalli, P.; Hommel, M.; Lambert, P.H.: Tumor necrosis factor and disease severity in children with falciparum malaria. New Engl. J. Med.320: 1586–1591 (1989).

    PubMed  CAS  Google Scholar 

  47. Grau, G.E.; Piguet, P.F.; Engers, H.D.; Louis, J.A.; Vassalli, P.; Lambert, P.H.: L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immun.137: 2348–2354 (1986).

    PubMed  CAS  Google Scholar 

  48. Kindler, V.; Sappino, A.P.; Grau, G.E.; Piguet, P.F.; Vassalli, P.: The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell56: 731–740 (1989).

    PubMed  CAS  Google Scholar 

  49. Leist, T.P.; Frei, K.; Kam-Hansen, S.; Zinkernagel, R.M.; Fontana, A.: Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral meningitis. J. exp. Med.167: 1743–1748 (1988).

    PubMed  CAS  Google Scholar 

  50. Mustafa, M.M.; Ramilo, O.; Olsen, K.D.; Franklin, P.S.; Hansen, E.J.; Beutler, B.; Maceracken, G.H.: Tumor necrosis factor in mediating experimentalHaemophilus influenzae type-B meningitis. J. clin. Invest.84: 1253–1259 (1989).

    PubMed  CAS  Google Scholar 

  51. Nakane, A.; Minagawa, T.; Kato, K.: Endogenous tumor necrosis factor (cachectin) is essential to host resistance againstListeria monocytogenes infection. Infect. Immunity56: 2563–2569 (1988).

    CAS  Google Scholar 

  52. Bowden, D.H.: Macrophages, dust and pulmonary diseases. Exp. Lung Res.12: 89–107 (1987).

    PubMed  CAS  Google Scholar 

  53. Hubbard, A.K.: Role for T lymphocytes in silica-induced pulmonary inflammation. Lab. Invest.61: 46–52 (1989).

    PubMed  CAS  Google Scholar 

  54. Piguet, P.F.; Collart, M.A.; Grau, G.E.; Sappino, A.P.; Vasalli, P.: Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature344: 245–247 (1990).

    PubMed  CAS  Google Scholar 

  55. Bowden, D.H.: Unraveling pulmonary fibrosis: the bleomycin model. Lab. Invest.50: 487–488 (1984).

    PubMed  CAS  Google Scholar 

  56. Adamson, I.Y.R.; Bowden, D.H.: Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Am. J. Path.96: 531–544 (1979).

    PubMed  CAS  Google Scholar 

  57. Aso, Y.; Yoneda, K.; Kikkawa, Y.: Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice. Lab. Invest.35: 558–568 (1976).

    PubMed  CAS  Google Scholar 

  58. Piguet, P.F.; Collart, M.A.; Grau, G.E.; Kapanci, Y.; Vassalli, P.: Tumor necrosis factor cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. exp. Med.170: 655–663 (1989).

    PubMed  CAS  Google Scholar 

  59. Schrier, D.J.; Phan, S.H.; McGary, M.: The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. Am. Rev. resp. Dis.127: 614–617 (1983).

    CAS  PubMed  Google Scholar 

  60. Korngold, R.; Sprent, J.: Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from the marrow. J. exp. Med.148: 1687–1698 (1978).

    PubMed  CAS  Google Scholar 

  61. Saurat, J.H.; Piguet, P.F.: Human and murine cutaneous graft-versus-host diseases. Potential models for the study of immunologically mediated skin diseases. Br. J. Derm.111: 213–218 (1984).

    Google Scholar 

  62. Piguet, P.F.; Grau, G.E.; Collart, M.A.; Vassallt, P.; Capanci, Y.: Pneumopathies of the graft-versus-host reaction. Lab. Invest.61: 37–45 (1989).

    PubMed  CAS  Google Scholar 

  63. Saitoh, T.; Fujiwara, M.; Nomoto, M.; Kamimura, T.; Ishiara, K.; Asakura, H.: Histologic studies on the hepatic lesions induced by graft versus host reaction in MHC class 1 disparate hosts compared with primary biliary cirrhosis. Am. J. Path.135: 301–307 (1989).

    PubMed  CAS  Google Scholar 

  64. Ferrara, J.L.M.; Guillen, F.J.; Van Dijken, P.J.; Marion, A.; Murphy, G.F.; Burakoff, S.J.: Evidence that large granular lymphocytes of donor origin mediate acute graft versus host disease. Transplantation47: 50–54 (1989).

    PubMed  CAS  Google Scholar 

  65. Parkman, R.: Graft-versus host disease: an alternative hypothesis. Immunol. today10: 362–364 (1989).

    PubMed  CAS  Google Scholar 

  66. Gale, R.P.: Graft-versus-host disease. Immunol. Rev.88: 193–214 (1985).

    PubMed  CAS  Google Scholar 

  67. Rappaport, H.; Khall, H.; Halle-Pannenko, O.; Pritchard, L.; Dantchev, D.; Mathe, G.: Histopathological sequence of events in adult mice undergoing lethal graft-versus-host reaction developed across H-2 and/or non H-2 histocompatibility barriers. Am. J. Path.96: 121–142 (1979).

    PubMed  CAS  Google Scholar 

  68. Dumler, J.S.; Beschorner, W.E.; Farmer, E.R.; DiGennaro, K.A.; Saral, R.; Santos, G.W.: Endothelial-cell injury in cutaneous acute graft versus host disease. Am. J. Path.135: 1097–1103 (1989).

    PubMed  CAS  Google Scholar 

  69. Piguet, P.F.: Tumor necrosis factor and graft versus host disease; in Burakoff et al., Graft versus host disease, research and clinical mangement (in press).

  70. Piguet, P.F.; Janin-Mercier, A.; Vassalli, P.; Saurat, J.H.: Epidermal lesions of the GVHR: evaluation of the role of different MHC and non MHC loci and of the Ly-2+ and L3T4+ T lymphocytes. J. Immun.139: 406–410 (1987).

    PubMed  CAS  Google Scholar 

  71. Piguet, P.F.: GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia and enteropathy. J. Immun.135: 1637–1643 (1985).

    PubMed  CAS  Google Scholar 

  72. Irle, C.; Salamin, A.F.; Bagucilupo, A.; Chapuis, B.; Gratwohl, A.; Hows, J.; Piguet, P.F.; Grau, G.E.: Serum TNF levels during graft versus host disease after bone marrow transplantation (abstract). BMT3: 127 (1988).

    Google Scholar 

  73. Shalaby, M.R.; Fendly, B.; Sheehan, K.C.; Schreiber, R.D.; Ammann, A.J.: Prevention of the graft-versus-host reaction in newborn mice by antibodies to tumor necrosis factor-alpha. Transplantation47: 1057–1061 (1989).

    PubMed  CAS  Google Scholar 

  74. Piguet, P.F.; Dewey, H.K.; Vassalli, P.: Origin and nature of the cells participating in the popliteal graft versus host reaction in mouse and rat. Cell. Immunol.31: 242–254 (1977).

    PubMed  CAS  Google Scholar 

  75. Stuart J.M.; Watson, W.C.; Kand, A.H.: Collagen autoimmunity and arthritis. FASEB J.2: 2950–2956 (1988).

    PubMed  CAS  Google Scholar 

  76. Robertson, B.; Gahrig, L.; Newton, R.; Daynes, R.: In vivo administration of interleukin-1 to normal mice depresses their capacity to elicit contact hypersensitivity responses: prostaglandins are involved in this modification of immune function. J. invest. Derm.88: 380–387 (1987).

    PubMed  CAS  Google Scholar 

  77. Cuturi, M.C.; Murphy, M.; Costa-Giomi, M.P.; Weinman, R.; Perussia, B.; Trinchieri, G.: Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes. J. exp. Med.165: 1581–1594 (1987).

    PubMed  CAS  Google Scholar 

  78. Grau, G.E.; Kindler, V.; Piguet, P.F.; Lambert, P.H.; Vassalli, P.: Prevention of experimental cerebral malaria by anticytokine antibodies. IL-3 and GM-CSF are intermediates in increased TNF production and macrophage accumulation. J. exp. Med.168: 1499–1504 (1988).

    PubMed  CAS  Google Scholar 

  79. Collart, M.A.; Belin, D.; Vassalli, J.D.; de Kossodo, S.; Vassalli, P.: Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin-1, and urokinase genes which are controlled by short lived repressor. J. exp. Med.163: 2113–2118 (1986).

    Google Scholar 

  80. Jacob, C.J.; Holoshitz, J.; Van der Meide, P.; Strober, S.; McDevitt, H.O.: Heterogeneous effects of IFN-gamma in adjuvant arthritis. J. Immun.142: 1500–1505 (1989).

    PubMed  CAS  Google Scholar 

  81. Biliau, A.; Heremans, H.; Vandekerckhove, F.; Dijkmans, R.; Sobis, H.; Meulepas, E.; Carton, H.: Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J. Immun.140: 1506–1510 (1988).

    Google Scholar 

  82. Grau, G.E.; Heremans, H.; Piguet, P.F.; Pointaire, P.; Lambert, P.H.; Billiau, A.; Vassalli, P.: Monoclonal antibody against interferon-gamma can prevent experimental cerebral malaria and its associated everproduction of tumor necrosis factor. Proc. natn. Acad. Sci. USA86: 5572–5574 (1989).

    CAS  Google Scholar 

  83. Mowat, A.M.: Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction. Immunology68: 18–23 (1989).

    PubMed  CAS  Google Scholar 

  84. Hyde, D.M.; Henderson, T.S.; Giri, S.N.; Tyler, N.K.; Stovall, M.Y.: Effect of murine gamma interferon on the cellular responses to bleomycin in mice. Exp. Lung Res.14: 687–704 (1988).

    PubMed  CAS  Google Scholar 

  85. Rosenbloom, J.; Feldman, G.; Freundlich, B.; Jimenez, S.A.: Transcriptional control of human diploid fibroblast collagen synthesis by gamma interferon. Biochem. biophys. Res. Commun.123: 365–372 (1984).

    PubMed  CAS  Google Scholar 

  86. Piguet, P.F.; Grau, G.E.; Irle, C.; Vassalli, P.: Administration of recombinant interleukin-2 to mice enhances production of hemopoietic and natural killer cells. Eur. J. Immunol.16: 1257–1261 (1986).

    PubMed  CAS  Google Scholar 

  87. Degliantoni, G.; Murphy, M.; Kobayashi, M.; Francis, M.K.; Perussia, B.; Trinchieri, G.: Natural killer (NK) cell derived hemopoietic colony inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J. exp. Med.162: 1512–1530 (1985).

    PubMed  CAS  Google Scholar 

  88. Economou, J.S.; McBride, W.H.; Essner, R.; Rhoades, K.; Golub, S.; Holmes, E.C.: Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo. Immunology67: 514–519 (1989).

    PubMed  CAS  Google Scholar 

  89. Ferrara, J.L.; Marion, A.; McIntyre, J.F.; Murphy, G.F.; Burakoff, S.J.: Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin-2 receptor antibody. J. Immun.137: 1847–1877 (1986).

    Google Scholar 

  90. Yocum, D.E.; Esparza, L.; Dubry, S.; Benjamin, J.B.; Volz, R.; Scideri, P.: Characteristics of tumor necrosis factor production in rheumatoid arthritis. Cell. Immunol.122: 131–145 (1989).

    PubMed  Google Scholar 

  91. Hofman, F.M.; Hinton, D.R.; Johnson, K.; Merrill, J.E.: Tumor necrosis factor identified in multiple sclerosis brain. J. exp. Med.170: 607–612 (1989).

    PubMed  CAS  Google Scholar 

  92. Gearing, A.J.H.; Finchmam, N.J.; Bird, C.R.; Wadhwa, M.; Meager, A.; Cartwright, J.E.; Camp, R.D.R.: Cytokines in skin lesions of psoriasis. Cytokine2: 68–75 (1990).

    PubMed  CAS  Google Scholar 

  93. Beutler, B.; Krochin, N.; Milsark, I.W.; Luedke, C.; Cerami, A.: Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science232: 977–980 (1986).

    PubMed  CAS  Google Scholar 

  94. Collart, M.; Belin, D.; Vassalli, J.D.; Vassalli, P.: Modulation of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-Fos gene transcription. J. Immun.139: 949–955 (1987).

    PubMed  CAS  Google Scholar 

  95. Remick, D.G.; Streiter, R.M.; Lynch, J.P.; Nguyen, D.; Eskandari, M.; Kunkel S.L.: In vivo dynamics of murine tumor necrosis factor-alpha gene expression. Kinetics of dexamethasone-induced suppression. Lab. Invest.60: 766–771 (1989).

    PubMed  CAS  Google Scholar 

  96. Grau, G.E.; Gretener, D.; Lambert, P.H.: Prevention of murine cerebral malaria by low-dose cyclosporin A. Immunology61: 521–525 (1987).

    PubMed  CAS  Google Scholar 

  97. Remick, D.G.; Nguyen, D.T.; Eskandari, M.K.; Strieter, R.M.; Kunkel, S.L.: Cyclosporine-A inhibits TNF production without decreasing TNF messenger RNA levels. Biochem. Biophys. Res. Commun.161: 551–555 (1989).

    PubMed  CAS  Google Scholar 

  98. Jacob, C.O.; McDevitt, H.O.: Tumour necrosis factor-alpha in murine autoimmune ‘lupus’ nephritis. Nature331: 356–358 (1988).

    PubMed  CAS  Google Scholar 

  99. Jacob, C.O.; Aiso, S.; Michie, S.A.; McDevitt, H.O.; Achaorbea, H.: Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF). Similarities between TNF-alpha and interleukin-1. Proc. natn. Acad. Sci. USA87: 968–972 (1990).

    CAS  Google Scholar 

  100. Satoh, J.; Seino, H.; Abo, T.; Tanaka, S.; Shintani, S.; Ohta, S.; Tamura, K.; Sawai, T.; Nobunaga, T.; Oteki, T.; Kumagai, K.; Toyota, T.: Recombinant human tumor necrosis factor-alpha suppresses autoimmune diabetes in nonobese diabetic mice. J. clin. Invest.84: 1345–1348 (1989).

    PubMed  CAS  Google Scholar 

  101. Gordon, C.; Wofsy, D.: Effects of recombinant tumor necrosis factor-alpha on immune function. J. Immun.144: 1753–1758 (1990).

    PubMed  CAS  Google Scholar 

  102. Chatenoud, L.; Ferran, C.; Reuter, A.; Legendre, C.; Gevaert, Y.; Kreis, H.; Franchimont, P.; Bach, J.F.: Systemic reaction to the anti-T-cell monoclonal antibody OKT3 in relation to serum levels of tumor necrosis factor and interferon-alpha. New Engl. J. Med.320: 1420–1421 (1989).

    PubMed  CAS  Google Scholar 

  103. Abramowicz, D.; Schandene, L.; Goldman, M.; Crusiaux, A.; Vereerstraeten, P.; De Pauw, L.; Wybran, J.; Kinnaert, P.; Dupont, E.; Toussaint, C.: Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant patients. Transplantation47: 606–608 (1989).

    PubMed  CAS  Google Scholar 

  104. Maury, C.P.J.; Teppo, A.M.: Tumor necrosis factor in the serum of patients with systemic lupus erythematosus. Arthritis Rheum.32: 146–150 (1989).

    PubMed  CAS  Google Scholar 

  105. Heath, A.W.: Cytokines and infection. Curr. Opinion Immunol.2: 380–384 (1990).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piguet, P.F., Grau, G.E. & Vassalli, P. Tumor necrosis factor and immunopathology. Immunol Res 10, 122–140 (1991). https://doi.org/10.1007/BF02918160

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02918160

Keywords

Navigation