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Histochemical and fine structural studies on the cornea with osteogenesis imperfecta congenita

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Virchows Archiv B

Summary

The corneae of a male infant which showed the classic symptoms of osteogenesis imperfecta and died after 17 days were studied fine structurally and histochemically. Control studies were performed on corneae from infants of the same age, dying from non-connective tissue disease. With the cornea of the osteogenesis imperfecta Alcian blue reaction was faint, Hale’s colloidal iron reaction negative. Metachromasia was less intensive and started at lower pH in comparison to normal specimens. High power electron micrographs revealed a diameter reduction of about 30% of the normal collagen fibers. Structures resembling cross striations were rarely found. But, even longitudinally arranged osmiophilic patterns were present in the fibers. Therefore, in this case repeating periods of the fibers could not be measured. Morphological findings are discussed in relation to recent biochemical studies in osteogenesis imperfecta.

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Authors and Affiliations

  1. Institute of Pathology, University of Kiel, Deutschland

    S. Blümcke & H. -R. Niedorf

  2. Ophtalmological Clinic, University of Kiel, Deutschland

    H. -J. Thiel

  3. Medical Clinic II, University of Kiel, Deutschland

    U. Langness

  4. Pathologisches Institut des Klinikum Essen der Ruhr-Universität, Hufelandstraße 55, D-4300, Essen, Federal Republic of Germany

    S. Blümcke

Authors
  1. S. Blümcke
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  2. H. -R. Niedorf
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  3. H. -J. Thiel
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  4. U. Langness
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Blümcke, S., Niedorf, H.R., Thiel, H.J. et al. Histochemical and fine structural studies on the cornea with osteogenesis imperfecta congenita. Virchows Arch. Abt. B Zellpath. 11, 124–132 (1972). https://doi.org/10.1007/BF02889392

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  • DOI: https://doi.org/10.1007/BF02889392

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