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The protein expression of bcl-2, bax, Fas/Apo-1 in acute myeloid leukemia

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Summary

The protein expression of bcl-2, bax, Fas/Apo-1 in 19 cases of acute myeloid leukemia (AMD were investigated by Western blot and ApAAp techniques. High expression of bcl-2 protein was found in most of the AML cases, and some of the cases expressed Fas/Apo-1 and bax. High expression of bcl-2 protein was associated with a bad clinical prognosis and a poor response after intensive chemotherapy. Bax seemed to coexpress with bcl-2 and so appeared to be a bad prognostic factor instead of a good one. The expression of Fas/Apo-1 was inversely correlated with bcl-2 and seemed to be a good prognostic factor which may reflect the relative homeostasis of apoptotic pathway. It is concluded that apoptosis-induced pathways in AML often exhibit disturbance features. Coregulation of bcl-2, Bax and Fas/Apo-1 genes formed the apoptosis-induced pathway, which is the biological factor affecting response to chemotherapy.

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Authors and Affiliations

  1. Department of Hematology, Tongji Hospital, Tongji Medical University, 430030, Wuhan

    Zhou Jianfeng M. D., Ph. D., Chen Yan, Li Chongyu & Liu Wenli

  2. Institute of Hematology, Tonhji Medical University, 430022, Wuhan

    Chen Yan & Li Chongyu

Authors
  1. Zhou Jianfeng M. D., Ph. D.
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  2. Chen Yan
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  3. Li Chongyu
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  4. Liu Wenli
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This project was supported by National Educational Committee Grant for Overseas Chinese Scholars.

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Jianfeng, Z., Yan, C., Chongyu, L. et al. The protein expression of bcl-2, bax, Fas/Apo-1 in acute myeloid leukemia. Current Medical Science 18, 42–45 (1998). https://doi.org/10.1007/BF02888279

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  • DOI: https://doi.org/10.1007/BF02888279

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