Summary
Mutations in the parkin gene have recently been identified in familial and isolated patients with early-onset Parkinson disease (PD) and that subregions between exon 2 and 4 of the parkin gene are hot spots of deletive mutations. To study the distribution of deletions in the parkin gene among variant subset patients with PD in China, and to explore the role of parkin gene in the pathogenesis of PD, 63 patients were divided into early onset and later onset groups. Exons 1–12 were amplified by PCR, templated by the genomic DNA of patients, and then the deletion distribution detected by agarose electrophoresis. Four patients were found to be carrier of exon deletions in 63 patients with PD. The location of the deletion was on exon 2 (1 case), exon 3 (2 cases) and exon 4 (1 case). All patients were belong to the group of early onset PD. The results showed that parkin gene deletion on exon 2, exon 3 and exon 4 found in Chinese population contributes partly to early onset PD.
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WANG Tao, male, born in 1961, Associate Professor
This project was supported by grants from the key program of the special scientific project of Scientific & Technologic Agency of Hubei province (No. 2001AA308B01) and the hygienic research project of Hygienic Agency of Hubei province (No. WJ 01529).
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Tao, W., Zhihou, L., Shenggang, S. et al. Exon deletions of parkin gene in patients with parkinson disease. Current Medical Science 24, 262–265 (2004). https://doi.org/10.1007/BF02832007
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DOI: https://doi.org/10.1007/BF02832007