Summary
In order to study the expressions of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in human laryngeal squamous cell carcinoma (LSCC) and its significance, the expression of VEGF mRNA and COX-2 mRNA in 62 cases of LSCC and 54 adjacent noncancerous laryngeal tissues and 9 normal human laryngeal mucous tissues was detected by using techniques of semi-quantitative RT-PCR. It was found that the expression level of VEGF and COX-2 mRNA was significantly increased in LSCC as compared with that in the normal human laryngeal mucous tissues (bothP<0.01), and the expression level of VEGF and COX-2 mRNA were significantly increased in stage III+IV tissues of LSCC as compared with the stage I+II tissues of LSCC (P<0.01). There was a high positive correlation between VEGF and COX-2 expression in LSCC (r=0.756,P<0.01). These data raise the possibility that VEGF and COX-2 may play key roles in the growth, invasion and metastasis of LSCC.
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CHEN Guangli, male, born in 1971. M. D., Ph. D.
This work was supported by the 4th Teaching and Research Award for Outstanding Young Teachers in Higher Education Institutions of the Ministry of Education. China
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Guangli, C., Yingpeng, L., Jianting, W. et al. Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 26, 105–107 (2006). https://doi.org/10.1007/BF02828052
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DOI: https://doi.org/10.1007/BF02828052