Summary
Gastrin releasing peptide(GRP)-like immunoreactivity in human plasma was measured using radioimmunoassay of neuromedin C (NMC) in 83 healthy and 58 diseased subjects. In the healthy group, the mean value of fasting GRP-like immunoreactivity was 2.1±1.4 (mean±SD) pmol/L. There was a slight positive correlation between the GRP-like immunoreactivity values and aging. Postprandial serial measurements demonstrated that GRP-like immunoreacitivity showed no response to a significant elevation of serum gastrin concentration. The group with chronic renal failure on hemodialysis gave the highest value, 7.1+2.1 pmol/L (p<0.01). There were no statistical differences between the healthy controls and groups with peptic ulcer, liver cirrhosis, diabetes mellitus or carcinomas, although some cancer patients had a marked increase in GRP-like immunoreactivity value.
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Haraguchi, Y., Sakamoto, A., Yoshida, T. et al. Plasma GRP-like immunoreactivity in healthy and diseased subjects. Gastroenterol Jpn 23, 247–250 (1988). https://doi.org/10.1007/BF02779466
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DOI: https://doi.org/10.1007/BF02779466