Abstract
Human immunodeficiency virus (HIV) causes a chronic infection that leads to profound immunosuppression. A hallmark of this process is the depletion of CD4 + lymphocytes, which predisposes the patient to develop a variety of opportunistic infections and certain neoplasms. The CD4 + lymphocyte count is the best validated predictor of the likelihood of developing opportunistic infections (OI). Susceptibility to OI increases as HIV induced immunosuppression becomes more severe. The management of HIV infection hence involves not only inhibeting viral replication using antiretroviral drugs, but also treating OI. This article focuses on the management of such commonly occurring OI in HIV infected patients.
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References
Centers for Disease Control and Prevention. 1994 revised classification system for HIV Infection in Children less than 13 years of age.MMWR Morb Mortal Wkly Rep 1994; 43: 1–17.
NACO, Training Manual For Doctors National AIDS Control Organization New Delhi, 2000.
Ellauriem M, Burns ER, Rubinstein A. Hematologic manifestations in pediatric HIV infection: Severe anemia as prognostic factor.Am J Pediatr Hematol Oncol 1990; 12 : 449–453.
Yolken RH, Shuojia LI, Perman Jet al. Persistent diarrhea and fecal shedding of Retroviral nucleic acids in children infected with HIV.J Infect Dis 1991; 164: 61–66.
Joshi VV, Pawel B, Conner Eet al. Arteriopathy in children with AIDS.Pediatr Pathol 1987; 7: 261–275.
Chaisson RE, Keiser P, Pierce Met al. Clarithromycin and etambutol with or without clofazimine for disseminated MAC infection in patients with AIDS.AIDS 1997; 11: 311.
Luzuriaga K, Bryson Y, Krogstad Pet al. Combination therapy with zidovudine, didanosine, and nevirapine in infants with HIV-1 infection.N Eng J Med 1997; 336: 1343.
Melvim AJ, Mohan KM, Arcuino LAet al. Clinical, Virologic and immunologic responses of children with advanced HIV-1 disease treated with protease inhibitors.Pediatr Infect Dis J 1997; 16: 968.
Michelet C, Arvieux C, Francois Cet al. Opportunistic infections occurring during highly active antiretroviral treatment.AIDS 1998; 12: 1815.
Abrams EJ, Weedon J, Steketee RWet al. Association of HIV load in early life with disease progression among HTV infected infants.J Infect Dis 1998; 178: 101–103.
Mofenson LM, Korelitz J, Meyer WAet al. The relationship between serum HIV 1 RNA level, CD4 lymphocyte percent, and long erm mortality risk in HIV 1 infected children.J Infect Dis 1997; 175: 1029.
Center for Diseases Control and Prevention: Revision of the CDC surveillance case definition for AIDS.MMWR CDC Surveill Summ 1987; 36 (Suppl) : 1–15.
National Iinstitute of Child Health and Human Development Intravenous Immunoglobulin Study Group: Intravenous immunoglobulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection.N Engl J Med 1991; 73 : 325.
Hughes WT. Pneumocystis Carinii pneumonia: New approaches to diagnosis, treatment and prevention.Pediatr Infect Dis J 1991; 10 : 391–399.
McLaughlin GE, Virdee SS, Schleien CLet al. Effect of steroid on survival of children with AIDS and PC related respiratory failure.J Pediatr 1995; 126: 821–824.
Sleasmen JW, Hemenway C, Kelin ASet al. Corticosteroids improve survival of children with AIDS and PCP.Am J Dis Child 1993; 147: 30.
Centers for Disease Control and prevention: 1995 Revised guidelines for prophylaxis against PCP for children infected or perinatally exposed to HIV.MMWR Morb Mortal Wkly Rep 1995; 44 : 1.
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Merchant, R.H., Quadir, Z.A. Management of opportunistic infections in pediatric HIV. Indian J Pediatr 69, 973–977 (2002). https://doi.org/10.1007/BF02726017
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DOI: https://doi.org/10.1007/BF02726017