Abstract
Synthetic ACTH1–24 analogue administered in a daily dose of 0.01 mg/kg decreased the number and size of mast cells and increased intracellular serotonin concentration. ACTH1–24 induced degranulation of young mast cells and release of undersulfated heparin. Correlation analysis showed that hormonal imbalance produced by ACTH1–24 was accompanied by redistribution of bioamines.
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References
I. G. Akmaev,Morfologiya, Nos. 9–10, 36 (1993).
I. G. Akmaev and V. V. Grinvich,Byull. Eksp. Biol. Med.,131, No. 1, 22–32 (2001).
T. L. Petrova and V. E. Sergeeva,Neurotransmitter Supply to Microstructures of the Thymus during Ovariectomy and Estrogen Treatment [in Russian], Cheboksary (2002).
E. A. Smirnova, B. A. Umarova, G. N. Kopylova, and E. L. Goncharova,Byull. Eksp. Biol. Med.,135, No. 1, 17–20 (2003).
F. V. Shapiro, B. A. Umarova, and S. M. Srukova,|Ibid.,Byull. Eksp. Biol. Med.,120, No. 10, 349–352 (1995).
I. Aebischer, M. R. Stampfli, A. Zurcher,et al., Eur. J. Immunol.,24, No. 8, 1908–1913 (1994).
A. Armario, M. Giralt, O. Marti,et al., Edocr. Res.,20, No. 2, 139–149 (1994).
C. Delrue-Perollet, K. S. Li, S. Vitiello, and P. J. Neveu,Brain Behav. Immun.,9, No. 2, 149–162 (1995).
L. D. Van de Kar, M. C. Alvarez Sanz, and J. M. Yracheta,Pharmacol. Biochem. Bheav.,48, No. 2, 429–436 (1994).
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 7, pp. 107–110, July, 2004
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Naumova, E.M., Sergeeva, V.E. Histochemical study of mast cells from the thymus of mice receiving ACTH1–24 . Bull Exp Biol Med 138, 93–96 (2004). https://doi.org/10.1007/BF02694485
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DOI: https://doi.org/10.1007/BF02694485