Summary
Very little is known about the presence of autonomic neuropathy in subjects with slight abnormalities of glucose metabolism. This study was carried out to investigate whether impaired glucose tolerance (IGT) is associated with abnormalities of beat-to-beat variation (BTBV). Sixty-two subjects, aged 40–59 years, with IGT (according to EASD criteria) and 124 normals, matched for age, sex and body mass index (BMI), were selected among the participants in a health examination survey and tested for BTBV. Among the possible factors influencing this test, sex did not show any effect, while age and BMI were significantly and negatively correlated to BTBV in both groups. Glucose intolerance was not associated with any impairment of BTBV which was almost identical in the normal (15.8±6.3 beats/min) (mean ± SD) and in the IGT group (16.7±7.0 beats/min). Similarly no significant difference was found in BTBV between subjects with constant IGT or normal results at OGTT, repeated on two occasions. All subjects were then stratified according to blood glucose values 2 h after an oral glucose load (after load): only those with blood glucose after load >200 mg/dl displayed a significant decrease in BTBV (9.7±3.8 beats/min) compared to those found normal at the glucose tolerance test (p<0.025). They were also the only ones with an average HbA1 level significantly higher than in normal individuals (p<0.005). In conclusion, IGT is not associated with abnormalities of BTBV.
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PaAl Sayegh H., Jarrett R. J.: Oral glucose tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall study — Lancetii, 431, 1979.
Bennett P. H.: Discussion on tests of neurological function in Pima Indians. In:Camerini Dávalos RS, Cole H. S. (Eds): Vascular and neurological changes in early diabetes. Academic Press, New York, 1973; p. 273.
Dorf A., Ballantyne E. J., Bennett P. H., Miller M.: Retinopathy in Pima Indians — Diabetes25, 554, 1976.
Dyrberg T., Benn J., Cristiansen J. S., Hilsted J., Nerup J.: Prevalence of diabetic autonomic neuropathy measured by simple bedside tests — Diabetologia20, 190, 1981.
Ellenberg M.: Diabetic neuropathy: clinical aspects — Metabolism25, 1627, 1976.
Hilsted J., Jensen S. B.: A simple test for autonomic neuropathy in juvenile diabetics — Acta med. scand.205, 385, 1979.
Hjelm M.: Enzymatic determination of hexoses in blood and urine — Scand. J. clin. Lab. Invest.18 (Suppl. 192), 85, 1966.
Jarrett R. J., Keen H.: Hyperglycemia and diabetes mellitus — Lancetii, 1009, 1976.
Jarrett R. J., Keen H., Fuller J. M., McCartney M.: Worsening to diabetes in men with impaired glucose tolerance (‘borderline diabetes’) — Diabetologia16, 25, 1979.
Kamenetzmy S. A., Bennett P. H., Dippe S. E., Miller M., LeCompte P. M.: A clinical and histological study of diabetic nephropathy in the Pima Indians — Diabetes23, 61, 1974.
Keen H., Jarrett R. J., Alberti K. G. M. M.: Diabetes mellitus: a new look at diagnostic criteria — Diabetologia16, 283, 1979.
Mackay J. D., Page M. Mc B., Cambridge J., Watkins P. J.: Diabetic autonomic neuropathy: the diagnostic value of heart rate monitoring — Diabetologia18, 471, 1980.
National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance — Diabetes28, 1039, 1979.
Pfeifer M. A., Cook D. L., Crill W. E., Weinberg C.: Early autonomic dysfunction in non-insulin dependent diabetics — Diabetes30 (Suppl. 1), 117, 1981.
Rochester D. F., Arora N. S.: Respiratory failure from obesity. In: Mancini M., Lewis B., Contaldo F. (Eds): Medical complications of obesity. Academic Press, New York, 1979; p. 183.
Snedecor G. W., Cochran W. H.: Statistical methods. Ames/Ia, 1967.
Sundkvist G., Lilja B., Almér L. O.: Abnormal diastolic blood pressure and heart rate reactions to tilting in diabetes mellitus — Diabetologia19, 433, 1980.
Watkins P. D., MacKay J. D.: Cardiac denervation in diabetic neuropathy — Ann. intern. Med.92 (Part 2), 304, 1980.
Welch S. G., Baucher B. J.: A rapid micro-scale method for the measurement of hemoglobin A1 (a+b+c) — Diabetologia14, 209, 1978.
Wheeler T., Watkins P. J.: Cardiac denervation in diabetes — Brit. med. J.iv, 584, 1973.
WHO Expert Committee on Diabetes Mellitus: Second Report of World Health Organization — Techn. Rep. Series 646, Geneva, 1980.
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Annuzzi, G., Rivellese, A., Vaccaro, O. et al. The relationship between blood glucose concentration and beat-to-beat variation in asymptomatic subjects. Acta diabet. lat 20, 57–62 (1983). https://doi.org/10.1007/BF02629130
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DOI: https://doi.org/10.1007/BF02629130