Abstract
Background
Secretory carcinoma is a distinctive and rare variant of breast carcinoma with a favorable prognosis because these tumors usually behave in an indolent manner. The occurrence of this type of breast cancer in males was studied.
Methods
An extensive literature survey concerning secretory breast cancer in males was performed. Data of one case treated in our institute were added.
Results
A total of 14 cases were identified, and our case was added to this series. The median age was 17 years. The duration of symptoms varied from 1 month to 21 years, and the tumor size was 1.2 to 4 cm. Surgical treatment varied from local excision only to modified radical mastectomy. Three patients received adjuvant treatment. Lymph nodes were involved in 3 of the 10 cases undergoing axillary lymph node dissection. The primary tumor was only 1.5 cm in diameter in two of those cases. None of the patients presented with systemic metastases. Only one male was reported to develop recurrence and consequently died of systemic disease.
Conclusions
Secretory breast cancer is very rare in males and seems to occur at a younger age in males than in females. A sufficient number of female cases have been reported with recurrence after local excision. Although in females lymph node metastases are rarely observed in secretory breast carcinoma smaller than 2 cm, in male patients nodal metastases might occur more frequently in smaller tumors. Therefore, mastectomy with sentinel lymph node biopsy or axillary lymph node dissection is recommended in any male case. Biological behavior seems to be similarly favorable in either sex.
Similar content being viewed by others
References
Donegan WL, Redlich PN. Breast cancer in men.Surg Clin North Am 1996;76:343–63.
Visfel J, Scheike O. Male breast cancer. I. Histologic subtyping and grading of 187 Danish cases.Cancer 1973;32:985–90.
Simpson JS, Barson AJ. Breast tumours in infants and children: a 40-year review of cases at a children’s hospital.Can Med Assoc J 1969;101:100–2.
Tavassolli FA, Norris HJ. Secretory carcinoma of the breast.Cancer 1980;45:2404–13.
Karl SR, Ballantine TVN, Zaino R. Juvenile secretory carcinoma of the breast.J Pediatr Surg 1985;20:368–71.
Roth JA, Discafani C, O’Malley M. Secretory breast carcinoma in a man.Am J Surg Pathol 1988;12:150–4.
Krausz T, Jenskins D, Grontoft O, Pollock DJ, Azoopardi JG. Secretory carcinoma of the breast in adults: emphasis on late recurrence and metastasis.Histopathology 1989;14:25–36.
Serour F, Gilad A, Kopolovic J, Krispin M. Secretory breast cancer in childhood and adolescence: report of a case and review of the world literature.Med Pediatr Oncol 1992;20:341–4.
Lamovec J, Bracko M. Secretory carcinoma of the breast: light microscopical, immunohistochemical flow cytometric study.Mod Pathol 1994;7:475–9.
Pohar-Marinsek Z, Golouh R. Secretory breast cancer in a man diagnosed by fine needle aspiration biopsy.Acta Cytol 1994;38: 446–50.
Kuwabara H, Yamane M, Okada S. Secretory breast carcinoma in a 66 year old man.J Clin Pathol 1998;51:545–7.
Vesoulis Z, Kashkari S. Fine needle aspiration of secretory breast carcinoma resembling lactational changes.Acta Cytol 1998;42: 1032–6.
Kameyama K, Mukai M, Iri H, et al. Secretory carcinoma of the breast in a 51-year-old male.Pathol Int 1998;48:994–7.
Chevallier A, Boissy C, Rampal A, et al. Le carcinome secretoire du sein. A propos d’une observation chez un garcon de 9 ans.Clin Exp Pathol 1999;47:88–91.
Yildirim E, Turhan N, Pak I, Berberoglu U. Secretory breast carcinoma in a boy.Eur J Surg Oncol 1999;25:98–9.
Bhagwandeen BS, Fenton L. Secretory carcinoma of the breast in a 9-year-old boy.Pathology 1999;31:166–8.
Titus J, Sillar RW, Fenton LE. Secretory breast carcinoma in a 9-year-old boy.Aust N Z J Surg 2000;70:144–6.
McDivitt W, Stewart FW. Breast carcinoma in children.JAMA 1966;195:144–6.
Rosen PP, Cranor ML. Secretory carcinoma of the breast.Arch Pathol Lab Med 1991;115:141–4.
Richard G, Hawk JC III, Baker AS Jr, Austin RM. Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature.J Surg Oncol 1990;44:238–44.
Sasco AJ, Lowenfels AB, Pasker-de Jong P. Review article: epidemiology of male breast cancer—a meta-analysis of published case-control studies and discussion of selected aetiological factors.Int J Cancer 1993;53:538–49.
Maitra A, Tavassoli FA, Albores-Saavedra J, et al. Molecular abnormalities associated with secretory carcinomas of the breast.Hum Pathol 1999;30:1435–40.
Murphy JJ, Morzaria S, Gow KW, Magee JF. Breast cancer in a 6-year-old child.J Pediatr Surg 2000;35:765–7.
Nonomura A, Kimura A, Mizukami Y, et al. Secretory carcinoma of the breast associated with juvenile papillomatosis in a 12-year-old girl.Acta Cytol 1995;39:569–76.
Akthar M, Robinson C, Ali MA, Godwin J. Secretory carcinoma of the breast in adults. Light and electron microscopic study of three cases and review of the literature.Cancer 1983;51:2404–13.
Tournemaine N, Audoiin AF, Anguill C, Gordeeff S. Le carcinome secretoire juvenile: cinq nouveaus cas chez des femmes d’age adulte.Arch Anat Cytol Pathol 1986;34:146–51.
Nguyen G, Neifer R. Aspiration biopsy cytology of secretory carcinoma of the breast.Diagn Cytopathol 1987;3:234–7.
Gupta RK, Kenwright D, Narran S, Lallu S, Fauck R. Fine needle aspiration cytodiagnosis of secretory carcinoma of the breast.Cytopathology 2000;11:496–502.
Mies C. Recurrent secretory carcinoma in residual mammary tissue after mastectomy.Am J Surg Pathol 1993;17:715–21.
Sullivan JJ, Magee HR, Donald KJ. Secretory (juvenile) carcinoma of the breast.Pathology 1977;9:341–6.
Sanidas EE, Tsiftsis DD. Technical details for the sentinel node biopsy in breast cancer: a guide for the training process.Eur J Surg Oncol 2001;27:414–27.
Port ER, Fey JV, Cody HS III, Borgen PI. Sentinel node biopsy in patients with male breast carcinoma.Cancer 2001;91:319–23.
Herz H, Cooke B, Goldstein D. Metastatic secretory breast cancer. Non-responsiveness to chemotherapy: case report and review of the literature.Ann Oncol 2000;11:1343–7.
Osborne CK. Steroid hormone receptors in breast cancer management.Breast Cancer Res Treat 1998;51:227–3.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Bree, E., Askoxylakis, J., Giannikaki, E. et al. Secretory carcinoma of the male breast. Annals of Surgical Oncology 9, 663–667 (2002). https://doi.org/10.1007/BF02574482
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02574482