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Tacalcitol (1,24(OH)2D3, TV-02) inhibits phorbol ester-induced epidermal proliferation and cutaneous inflammation, and induces epidermal differentiation in mice

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Abstract

In this study, we examined the cutaneous effects of tacalcitol [1, 24(R)(OH)2D3] on epidermal proliferation, differentiation, and skin inflammation in vivo using hairless mice. Tacalcitol was shown to inhibit epidermal proliferation using TPA-induced ornithine decarboxylase activity and DNA synthesis as indices, and the induction of epidermal differentiation using type I transglutaminase activity as an index. Tacalcitol also displayed an antiinflammatory effect on TPA-induced inflammatory changes histopathologically. These results confirm the clinical efficacy of tacalcitol in psoriasis, and suggest that it may be efficacious in the treatment of other inflammatory skin diseases.

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Authors and Affiliations

  1. Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka, Hino, 191, Tokyo, Japan

    Hiroaki Sato, Izuki Sugimoto, Takashi Matsunaga, Masahiro Tsuchimoto, Tomohiro Ohta, Hiroshi Uno & Mamoru Kiyoki

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  1. Hiroaki Sato
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  2. Izuki Sugimoto
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  3. Takashi Matsunaga
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  7. Mamoru Kiyoki
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Sato, H., Sugimoto, I., Matsunaga, T. et al. Tacalcitol (1,24(OH)2D3, TV-02) inhibits phorbol ester-induced epidermal proliferation and cutaneous inflammation, and induces epidermal differentiation in mice. Arch Dermatol Res 288, 656–663 (1996). https://doi.org/10.1007/BF02505274

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  • DOI: https://doi.org/10.1007/BF02505274

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