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Effect of age on plasma 1,25-(OH)2 vitamin D in the rat

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Abstract

Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)2-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20–24 months (senescent). Plasma 1,25-(OH)2-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p < 0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p < 0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.

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Authors and Affiliations

  1. Department of Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin

    Richard W. Gray & Steven R. Gambert

  2. Wood VA Medical Center, Wood (Milwaukee), Wisconsin

    Steven R. Gambert

Authors
  1. Richard W. Gray
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  2. Steven R. Gambert
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Gray, R.W., Gambert, S.R. Effect of age on plasma 1,25-(OH)2 vitamin D in the rat. AGE 5, 54–56 (1982). https://doi.org/10.1007/BF02431725

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  • DOI: https://doi.org/10.1007/BF02431725

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