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ΔF508 frequency and associated haplotypes near the cystic fibrosis locus in the Yugoslav population

  • Population analysis of the major mutation in cystic fibrosis
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Summary

Chromosomes from 19 unrelated Southern Yugoslav families in which cystic fibrosis (CF) occurs were analysed for the presence of the ΔF508 mutation, using polymerase chain reaction amplification followed by dot blot and polyacrylamide gel analysis. Of the 38 CF chromosomes, 15 (39.5%) carry the ΔF508 deletion. Restriction fragment length polymorphism haplotypes for KM19/PstI, XV2c/TaqI and J3.11/PstI marker loci were determined and are compared for a total of 34 N and 37 CF chromosomes.

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Authors and Affiliations

  1. Regional DNA Laboratory, St. Mary's Hospital Medical School, Norfolk Place, W2 1PG, London, UK

    Lidija Simova, Carolyn Williams, Eila K. Watson & Robert Williamson

  2. Research Center for New Technologies, Macedonian Academy of Sciences and Arts, Krste Misirkov bb, YU-91000, Skopje, Yugoslavia

    Lidija Simova & Georgi D. Efremov

  3. Department of Pediatrics, Faculty of Medicine, Vodnjanska, YU-91000, Skopje, Yugoslavia

    Aleksandra Gordova-Muratovska & Stojka Suštić

Authors
  1. Lidija Simova
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  2. Carolyn Williams
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  3. Georgi D. Efremov
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  4. Aleksandra Gordova-Muratovska
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  5. Stojka Suštić
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  6. Eila K. Watson
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  7. Robert Williamson
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Simova, L., Williams, C., Efremov, G.D. et al. ΔF508 frequency and associated haplotypes near the cystic fibrosis locus in the Yugoslav population. Hum Genet 85, 432–433 (1990). https://doi.org/10.1007/BF02428301

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  • DOI: https://doi.org/10.1007/BF02428301

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