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Normal milk composition in lactating X-linked hypophosphatemic mice despite continued hypophosphatemia

  • Laboratory Investigations
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Summary

Patients with X-linked hypophosphatemia and mice bearing theHyp gene have reduced renal tubular reabsorption of phosphate and an osteomalacic bone disease. To test if altered phosphate transport also exists in the mammary glands, milk was analyzed from normal (n=9) and heterozygousHyp (n=8) mice 14 days after giving birth. Inorganic phosphate, total phosphate, calcium, magnesium, sodium, and potassium were measured; percent cream, fat, water, and nonfat organic solids were measured; and protein was measured. No significant differences (NSD) were found except for greater sodium inHyp milk. There was also NSD in litter weight. The lactatingHyp had a lower body weight and remained hypophosphatemic relative to lactating normals, but both groups had higher plasma phosphate than nonlactating controls of the same genotype. The data suggest thatHyp mice can accumulate a normal amount of phosphate in their milk despite the plasma phosphate being two-thirds of normal. These data, with other recent reports of different organ systems, suggest that the altered phosphate transport activity may be restricted to the kidney.

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Authors and Affiliations

  1. Department of Basic Sciences, School of Dentistry, Marquette University, 604 N. 16th Street, 53233, Milwaukee, WI, USA

    Pamela R. Delzer & Ralph A. Meyer Jr.

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  1. Pamela R. Delzer
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  2. Ralph A. Meyer Jr.
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Delzer, P.R., Meyer, R.A. Normal milk composition in lactating X-linked hypophosphatemic mice despite continued hypophosphatemia. Calcif Tissue Int 35, 750–754 (1983). https://doi.org/10.1007/BF02405118

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  • DOI: https://doi.org/10.1007/BF02405118

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