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Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock

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Abstract

Previous studies have shown that stressors attenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of amphetamine-CTA. Experiment 2 demonstrated that exposure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experiment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-injected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCl CTA. They also add support to the contention that CTAs induced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic substances like LiCL.

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Authors and Affiliations

  1. Centre for Studies in Behavioral Neurobiology, Dept. Psychology, Concordia University, 1455 de Maisonneuve Blvd. West, H3G 1M8, Montreal, Quebec, Canada

    W. J. Bowers & Z. Amit

  2. Department of Psychoneuropharmacologie, Catholic University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    M. A. Gringras

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  1. W. J. Bowers
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  2. Z. Amit
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  3. M. A. Gringras
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Bowers, W.J., Amit, Z. & Gringras, M.A. Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock. Psychopharmacology 125, 43–49 (1996). https://doi.org/10.1007/BF02247391

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  • DOI: https://doi.org/10.1007/BF02247391

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